Chylomicron Metabolism and ?3 and �6 Fatty Acids

2015 ◽  
pp. 23-25 ◽  
Author(s):  
William S. Harris
Keyword(s):  
Fatty Acids ◽  
Chylomicron Metabolism

scholarly journals N-3 fatty acids and chylomicron metabolism in the rat

1997 ◽  
Vol 38 (3) ◽  
pp. 503-515
Author(s):  
W S Harris ◽  
B E Hustvedt ◽  
E Hagen ◽  
M H Green ◽  
G Lu ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Chylomicron Metabolism

Chylomicron metabolism by the isolated perfused mouse heart

2001 ◽  
Vol 281 (2) ◽  
pp. E357-E364 ◽  
Author(s):  
Kai Mardy ◽  
Darrell D. Belke ◽  
David L. Severson
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Lipoprotein Lipase ◽  
Mouse Heart ◽  
Suitable Model ◽  
Experimental Conditions ◽  
Tissue Lipids ◽  
Metabolic Pool ◽  
Chylomicron Metabolism

The catabolism of rat chylomicrons, labeled in their triacylglycerol (TG) component, was investigated using perfused working mouse hearts. Perfusion of mouse hearts with heparin increased lipoprotein lipase (LPL) activity in the perfusate. This heparin-releasable LPL pool remained constant over a variety of experimental conditions, including workload and fatty acid concentrations, making the mouse heart a suitable model to study chylomicron catabolism. Endothelium-bound LPL hydrolyzed radiolabeled 3H-labeled chylomicrons (0.4 mM TG); the fate of LPL-derived 3H-labeled fatty acids was split evenly between oxidation (production of3H2O) and esterification (incorporation into tissue lipids, mainly TG). In comparison, the oxidation of 0.4 mM [3H]palmitate complexed to albumin was fourfold greater than esterification into tissue lipids. Surprisingly, the addition of unlabeled palmitate (0.4 or 1.2 mM) to perfusions with3H-chylomicrons did not affect the fate (either oxidation or esterification) of LPL-derived 3H-fatty acids. These results suggest that fatty acids produced from lipoprotein hydrolysis by the action of LPL and fatty acids from a fatty acid-albumin complex do not enter a common metabolic pool in the heart.

Fatty Acids and Glycerides

1979 ◽  
Vol 7 (4) ◽  
pp. 813-814
Author(s):  
J. L. HARWOOD
Keyword(s):  
Fatty Acids
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