Nutritional Status and the Immune System: Fat-Soluble Vitamins and Other Nutrients

Author(s):  
I. Elmadfa ◽  
C. Bartens ◽  
E. Jakob ◽  
J. K�nig
Author(s):  
Meghit Boumediene Khaled ◽  
Nada Benajiba

The immune system is involved in the protection of host against environmental agents such as pathogenic micro-organisms (bacteria, fungi, and viruses) and chemicals, thereby preserving the integrity of the body. To preserve organism defense mechanisms, adequate nutritional status should be maintained with appropriate intakes of calories, vitamins, minerals and water that should be continuously provided by a healthy diet. The emergence of new infectious diseases with new pathogenic properties constitutes a serious health issue worldwide. Severe acute respiratory syndrome (SARS) represents one of the most recent emerging infectious diseases, caused by a novel coronavirus member called (SARS-CoV-2), identified in Wuhan, Hubei, China in December 2019, and recognized as pandemic by the World Health Organization (WHO). The nutritional status of each COVID-19-infected patient should be assessed prior undertaking treatments. Nutritional support should be the basis of management of any infected individual. However, prevention measures remain the first priority and strategy to develop throughout proper hygiene, healthy diet and staying home. Keywords: Nutrition, Immune system, Viral diseases, SARS-CoV-2.


2021 ◽  
Vol 161 ◽  
pp. 210-218
Author(s):  
Victoria de Brun ◽  
Juan J. Loor ◽  
Hugo Naya ◽  
Andrea Graña-Baumgartner ◽  
Mario Vailati-Riboni ◽  
...  

1999 ◽  
Vol 58 (3) ◽  
pp. 707-711 ◽  
Author(s):  
Melinda A. Beck

The association between viral disease and nutrition has long been thought to be due to effects on the host immune system. This theory suggests that when a host is malnourished, the immune system is compromised, and thus increased susceptibility to viral infection will occur. However, the virus itself may also be affected by the nutritional status of the host. We have demonstrated that a normally-benign strain of coxsackievirus B3 (CVB3/0) becomes virulent in either Se-deficient or vitamin E-deficient mice. Although the deficient animals are immunosuppressed, the virus itself is also altered. Six nucleotide changes were found in the virus that replicated in the deficient mice, and once these mutations occurred, even mice with normal nutrition became susceptible to disease. Thus, the nutritional status of the host was able to transform an avirulent virus into a virulent one due to genomic changes in the virus. We believe that a common mechanism of oxidative stress is the underlying cause of the genetic changes. Both vitamin E and Se act as antioxidants, and benign virus inoculated into GSH peroxidase (EC 1.11.1.9)-knockout mice will also convert to virulence due to genomic changes. Our work points to the importance of host nutrition during a viral disease, not only from the perspective of the host, but from the perspective of the viral pathogen as well.


Author(s):  
Renata Silverio ◽  
Daniela Caetano Gonçalves ◽  
Márcia Fábia Andrade ◽  
Marilia Seelaender

ABSTRACT Coronavirus disease 2019 (COVID-19) is an emerging disease that has reached pandemic status by rapidly spreading worldwide. Elderly individuals and patients with comorbidities such as obesity, diabetes, and hypertension show a higher risk of hospitalization, severe disease, and mortality by acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. These patients frequently show exacerbated secretion of proinflammatory cytokines associated with an overreaction of the immune system, the so-called cytokine storm. Host nutritional status plays a pivotal role in the outcome of a variety of different infectious diseases. It is known that the immune system is highly affected by malnutrition, leading to decreased immune responses with consequent augmented risk of infection and disease severity. Body composition, especially low lean mass and high adiposity, has consistently been linked to worsened prognosis in many different diseases. In this review, evidence concerning the impact of nutritional status on viral infection outcomes is discussed.


Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2326
Author(s):  
Philip C. Calder ◽  
Anitra C. Carr ◽  
Adrian F. Gombart ◽  
Manfred Eggersdorfer

We thank Tsoupras and Zabetakis for their interest in our recent publication [...]


2020 ◽  
Vol 1 (1) ◽  
pp. 10-12
Author(s):  
Cecilia Medeiros de Morais

This review deals with the relationship among nutrition, the immune system, and coronavirus disease 2019 (COVID-19). The influence of nutrients and bioactive molecules present in foodstuffs on immune system activity, the influence of COVID-19 on the nutritional status of the patients, and the dietary recommendations for hospitalized patients are addressed. Deficient nutritional status is probably due to anorexia, nausea, vomiting, diarrhea, hypoalbuminemia, hypermetabolism, and excessive nitrogen loss. There is limited knowledge regarding the nutritional support during hospital stay of COVID-19 patients. However, nutritional therapy appears as first-line treatment and should be implemented into standard practice. Optimal intake of all nutrients, mainly those playing crucial roles in immune system, should be assured through a diverse and well-balanced diet. Nevertheless, in order to reduce the risk and consequences of infections, the intakes for some micronutrients may exceed the recommended dietary allowances since infections and other stressors can reduce micronutrient status. In the case of critically ill patients, recently published guidelines are available for their nutritional management. Further, several natural bioactive compounds interact with the angiotensin-converting enzyme 2 (ACE2) receptor, the gateway for severe acute respiratory syndrome (SARS) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Natural bioactive compounds can also reduce the inflammatory response induced by SARS-CoV-2. These compounds are potential beneficial tools in the nutritional management of COVID-19 patients.


2018 ◽  
Vol 2 (2) ◽  
pp. 48
Author(s):  
Sugiyanto Sugiyanto

Nutrition is one of determinant quality of human resources. Malnutrition will cause failure of physical growth and intellectual development, decrease productivity and immune system, which increases the morbidity and mortality. This Study was aimed to determine the correlation nutritional status with anemia event of students in class X SMK Muhammadiyah 2 Bejen Bantul Yogyakarta. The method used the analytic survey with cross sectional approach. The technique of data collection was using purposive sampling, sample used as many as 30 of students who have get anemic. The material and equipment which was used in this study including stationery, weight and height scales, electric appliance of Hb Measurement, alcohol cotton, handscon, and data analysis using non parametric statictical test with Kendall Tau. Based on non parametric statistic test using Kendall Tau test with significance level of 0.05 and p value (significance) of 0.000. In this study obtained p value (significance) was smaller than 0.05 (0.000 < 0.05) so that Ha is accepted. It can be concluded that there was a correlation of nutritional status with anemia event of students in class X SMK Muhammadiyah 2 Bejen Bantul Yogyakarta. It was hoped the students have to eat three times a day so that nutrition was fulfilled and not doing a wrong diet, so it has a good nutritional status and avoid anemia.


2021 ◽  
Vol 8 (2) ◽  
pp. 166-170
Author(s):  
Lutfi Wahyuni ◽  
Inna Octavia ◽  
Norma Cindy Erlina

Pulmonary TB disease is one of the priorities of eradication of infectious diseases. Early-stage drug breakup occurs if the patient does not take medication 2 months in a row or more before the treatment period is complete. Drug breakups result in patients being resistant to OAT (Anti-Tuberculosis Drugs) and can lead to complications. This study aimed to analyze the occurrence of complications of tuberculosis sufferers due to a history of drug breakup. The design in this study was Correlation Analytics with Retrospective approach methods. The population in this study was all TB sufferers who had a history of drug breakups and complications. The sampling technique in this study was Non-Probability Sampling with purposive sampling type. The sample was 30 respondents. The instruments were interview for the history of drug breakup and patient treatment cards and observation and status of patient as the instruments of complications. Spearman Rho test results showed that value = 0.055 or more than α (0.05) which meant there was no correlation between the history of drug breakup with complications of tuberculosis. Based on this study, it could be concluded that the complications of tuberculosis that occur not only because of drug breakup factors but can be due to the spread of increasingly widespread germ infections, the immune system of the sufferers who are lacking, tuberculosis concomitant diseases, nutritional status of tuberculosis sufferers, and also knowledge from TB sufferers who lack the awareness to maintain health.


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