Clinical Course of Nonsurgically Treated Zollinger-Ellison Syndrome

2015 ◽  
pp. 360-371 ◽  
Author(s):  
Basil I. Hirschowitz
Keyword(s):  
Clinical Course ◽  
Zollinger Ellison Syndrome

Prospective Study of the Clinical Course, Prognostic Factors, Causes of Death, and Survival in Patients With Long-Standing Zollinger-Ellison Syndrome

1999 ◽  
Vol 17 (2) ◽  
pp. 615-615 ◽  
Author(s):  
Fang Yu ◽  
David J. Venzon ◽  
Jose Serrano ◽  
Stephan U. Goebel ◽  
John L. Doppman ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Liver Metastases ◽  
Bone Metastases ◽  
Cushing’S Syndrome ◽  
Clinical Course ◽  
Cushing's Syndrome ◽  
Ectopic Cushing’S Syndrome ◽  
Zollinger Ellison Syndrome ◽  
Large Primary

PURPOSE: The long-term clinical course of unselected patients with gastrinomas as well as other functional pancreatic endocrine tumors (PETs) in whom the excess-hormone state is controlled is largely unknown. To address this issue, patients with gastrinomas were assessed. PATIENTS AND METHODS: Two hundred twelve patients with Zollinger-Ellison syndrome (ZES) were prospectively studied. All had controlled acid hypersecretion and were assessed yearly, with a mean follow-up period of 13.8 ± 0.6 years (range, 0.1 to 31 years). Annual assessments of possible factors that might affect prognosis or treatment approaches were performed, such as those for tumor size and location; the presence, location, and extent of metastases; and the occurrence of ectopic Cushing's syndrome or another PET syndrome. Deaths were categorized as ZES-related or non–ZES-related and classified into different causes. RESULTS: Thirty-one percent of patients died, all of non–acid-related causes. One half died of a ZES-related cause; they differed from those who died of non–ZES deaths by having a large primary tumor, more frequently a pancreatic tumor; lymph node, liver, or bone metastases; ectopic Cushing's syndrome; or higher gastrin levels. The extent of liver metastases correlated with survival rate. The presence of liver metastases alone only moderately decreased survival time; however, the additional development of bone metastases or ectopic Cushing's syndrome markedly decreased survival rate. CONCLUSIONS: In ZES, gastrinoma growth is now the main single determinant of long-term survival, with one half of patients dying a gastrinoma-related death and none an acid-related death. Large primary tumors that are pancreatic in location, the development of liver metastases, (especially if associated with bone metastases or Cushing's syndrome), and the extent of liver metastases are all important prognostic factors. The identification of these factors allows the recognition of subgroups that can be used to tailor antitumor treatment approaches.

Flow cytometry and Zollinger-Ellison syndrome: Relationship to clinical course

1993 ◽  
Vol 105 (3) ◽  
pp. 799-813 ◽  
Author(s):  
David C. Metz ◽  
Mirek Kuchnio ◽  
Douglass L. Fraker ◽  
David J. Venzon ◽  
Gitie Jaffe ◽  
...  
Keyword(s):  
Flow Cytometry ◽  
Clinical Course ◽  
Zollinger Ellison Syndrome

Ulcerogenic Tumors of the Pancreas

1968 ◽  
Vol 26 ◽  
pp. 186-187
Author(s):  
J. C. Garancis ◽  
J. F. Kuzma ◽  
S. D. Wilson ◽  
E. H. Ellison
Keyword(s):  
Endoplasmic Reticulum ◽  
Tumor Cells ◽  
Islet Cell ◽  
Disease Process ◽  
Central Core ◽  
Islet Cell Tumors ◽  
Opaque Zone ◽  
Granular Form ◽  
Zollinger Ellison Syndrome

It has been proposed that a gastrin-like hormone elaborated by non-beta islet tumors of the pancreas may be responsible for a fulminating ulcer diathesis. Subsequently, a potent gastric secretagogue was isolated from ulcerogenic tumors of the pancreas. This disease process is known now as “Zollinger-Ellison syndrome”.In our studies of two cases of Zollinger-Ellison syndrome, pancreatic lesions were identified as alpha islet cell tumors (Fig. 1). Tumor cells were fairly uniform. The sizes of the alpha granules were not significantly different, but their number and distribution varied greatly from one cell to another. Each granule consisted of a round, highly dense central core, separated from the limiting membrane by an opaque zone. The granular form of the endoplasmic reticulum was particularly prominent. Numerous mitochondria, round or elongated, were dispersed throughout the cytoplasm. Individual or clusters of lysosomes were observed in the majority of cells.

Efficacious long-term maintenance therapy with pantoprazole (PAN) in patients with Zollinger-Ellison syndrome

2001 ◽  
Vol 120 (5) ◽  
pp. A613-A613
Author(s):  
P BORNMAN ◽  
K RADEBOLD ◽  
H DEBAERE ◽  
L VENTER ◽  
H HEINZE ◽  
...  
Keyword(s):  
Maintenance Therapy ◽  
Zollinger Ellison Syndrome ◽  
Term Maintenance

Excluded Gastric Antrum Simulating the Zollinger-Ellison Syndrome

1964 ◽  
Vol 47 (2) ◽  
pp. 184-187 ◽  
Author(s):  
Brian A. Scobie ◽  
Douglas B. McGill ◽  
James T. Priestley ◽  
Randolph A. Rovelstad
Keyword(s):  
Gastric Antrum ◽  
Zollinger Ellison Syndrome

Zollinger-Ellison Syndrome

1963 ◽  
Vol 44 (4) ◽  
pp. 512-518 ◽  
Author(s):  
L. Angervall ◽  
G. Dotevall ◽  
K.-E. Lehmann ◽  
P.B. Norberg
Keyword(s):  
Zollinger Ellison Syndrome

74: How Septic is Urosepsis? Treatment and Clinical Course of Infected Hydronephrosis

2005 ◽  
Vol 173 (4S) ◽  
pp. 21-21
Author(s):  
Frank Christoph ◽  
Steffen Weikert ◽  
Markus Müller ◽  
Kurt Miller
Keyword(s):  
Clinical Course ◽  
Infected Hydronephrosis
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