Experimental Models of Endocrine Tumors of the Pancreas

2015 ◽  
pp. 70-83
Author(s):  
Daniel S. Longnecker
Keyword(s):  
Experimental Models ◽  
Endocrine Tumors

ACE2 as therapeutic agent

2020 ◽  
Vol 134 (19) ◽  
pp. 2581-2595
Author(s):  
Qiuhong Li ◽  
Maria B. Grant ◽  
Elaine M. Richards ◽  
Mohan K. Raizada
Keyword(s):  
Therapeutic Agent ◽  
Renin Angiotensin System ◽  
Peptide Hormone ◽  
Experimental Models ◽  
Electrolyte Balance ◽  
Ang Ii ◽  
Angiotensin Converting Enzyme 2 ◽  
Beneficial Effects ◽  
Overwhelming Evidence ◽  
Future Challenges

Abstract The angiotensin-converting enzyme 2 (ACE2) has emerged as a critical regulator of the renin–angiotensin system (RAS), which plays important roles in cardiovascular homeostasis by regulating vascular tone, fluid and electrolyte balance. ACE2 functions as a carboxymonopeptidase hydrolyzing the cleavage of a single C-terminal residue from Angiotensin-II (Ang-II), the key peptide hormone of RAS, to form Angiotensin-(1-7) (Ang-(1-7)), which binds to the G-protein–coupled Mas receptor and activates signaling pathways that counteract the pathways activated by Ang-II. ACE2 is expressed in a variety of tissues and overwhelming evidence substantiates the beneficial effects of enhancing ACE2/Ang-(1-7)/Mas axis under many pathological conditions in these tissues in experimental models. This review will provide a succinct overview on current strategies to enhance ACE2 as therapeutic agent, and discuss limitations and future challenges. ACE2 also has other functions, such as acting as a co-factor for amino acid transport and being exploited by the severe acute respiratory syndrome coronaviruses (SARS-CoVs) as cellular entry receptor, the implications of these functions in development of ACE2-based therapeutics will also be discussed.

Curcumin, a natural phytochemical, inhibits pancreatic NF-kB and AP-1 activation and amellorates pancreatitis in two experimental models

2001 ◽  
Vol 120 (5) ◽  
pp. A537-A537
Author(s):  
I GUKOVSKY ◽  
C REYES ◽  
E VAQUERO ◽  
A BAYCHER ◽  
A GUKOVSKAYA ◽  
...  
Keyword(s):  
Experimental Models

Experimental Models Of Ossiculoplasty

1994 ◽  
Vol 27 (4) ◽  
pp. 663-675 ◽  
Author(s):  
Richard L. Goode ◽  
Shinsei Nishihara
Keyword(s):  
Experimental Models

Experimental Models of CNS Infections: Contributions to Concepts of Disease and Treatment

1986 ◽  
Vol 4 (1) ◽  
pp. 249-264 ◽  
Author(s):  
M.G. Täuber ◽  
R.A. Brooks-Fournier ◽  
M.A. Sande
Keyword(s):  
Experimental Models ◽  
Cns Infections ◽  
Concepts Of Disease

Synergic evaluation of associations of crude Pterodon pubescens Benth dichloromethane extract and Varronia spp essential oil in antinociceptive experimental models

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
RT Basting ◽  
HM Spindola ◽  
VH Silva Souza ◽  
R Grando ◽  
RA Ferreira Rodrigues ◽  
...  
Keyword(s):  
Essential Oil ◽  
Experimental Models

Neutralization of a Low Molecular Weight Heparin (LHN-1) and Conventional Heparin by Protamine Sulfate in Rats

1986 ◽  
Vol 56 (03) ◽  
pp. 318-322 ◽  
Author(s):  
V Diness ◽  
P B Østergaard
Keyword(s):  
Molecular Weight ◽  
Low Molecular Weight Heparin ◽  
Thrombus Formation ◽  
Experimental Models ◽  
Protamine Sulfate ◽  
Low Molecular Weight ◽  
Antithrombotic Effect ◽  
Higher Doses

SummaryThe neutralization of a low molecular weight heparin (LHN-1) and conventional heparin (CH) by protamine sulfate has been studied in vitro and in vivo. In vitro, the APTT activity of CH was completely neutralized in parallel with the anti-Xa activity. The APTT activity of LHN-1 was almost completely neutralized in a way similar to the APTT activity of CH, whereas the anti-Xa activity of LHN-1 was only partially neutralized.In vivo, CH 3 mg/kg and LHN-1 7.2 mg/kg was given intravenously in rats. The APTT and anti-Xa activities, after neutralization by protamine sulfate in vivo, were similar to the results in vitro. In CH treated rats no haemorrhagic effect in the rat tail bleeding test and no antithrombotic effect in the rat stasis model was found at a protamine sulfate to heparin ratio of about 1, which neutralized APTT and anti-Xa activities. In LHN-1 treated rats the haemorrhagic effect was neutralized when APTT was close to normal whereas higher doses of protamine sulfate were required for neutralization of the antithrombotic effect. This probably reflects the fact that in most experimental models higher doses of heparin are needed to induce bleeding than to prevent thrombus formation. Our results demonstrate that even if complete neutralization of APTT and anti-Xa activities were not seen in LHN-1 treated rats, the in vivo effects of LHN-1 could be neutralized as efficiently as those of conventional heparin. The large fall in blood pressure caused by high doses of protamine sulfate alone was prevented by the prior injection of LHN-1.

Usefulness of MR Imaging in the Staging of Brain Abscess: Comparison between Experimental Models and Clinical Cases

1997 ◽  
Vol 37 (6) ◽  
pp. 975
Author(s):  
Yong Yeon Jeong ◽  
Heoung Keun Kang ◽  
Jeong Jin Seo ◽  
Yun Hyeon Kim ◽  
Jin Gyoon Park ◽  
...  
Keyword(s):  
Mr Imaging ◽  
Brain Abscess ◽  
Experimental Models ◽  
Clinical Cases

Multidisciplinary committee on endocrine tumors: an analysis of 6-year experience

2017 ◽  
Author(s):  
Juan J Diez ◽  
Pedro Iglesias ◽  
Teresa Alonso-Gordoa ◽  
Enrique Grande ◽  
Pablo Gajate
Keyword(s):  
Endocrine Tumors
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