Impacts of Blood Screening on the Incidence of Posttransfusion Hepatitis C in Japan

2015 ◽  
pp. 182-194
Author(s):  
Hiroshi Yoshizawa ◽  
Junnosuke Watanabe
Keyword(s):  
Hepatitis C ◽  
Posttransfusion Hepatitis ◽  
Blood Screening

scholarly journals History of posttransfusion hepatitis

1997 ◽  
Vol 43 (8) ◽  
pp. 1487-1493 ◽  
Author(s):  
Leslie H Tobler ◽  
Michael P Busch
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Hepatitis B ◽  
Hepatitis Virus ◽  
Hepatitis B Surface Antigen ◽  
Substantial Reduction ◽  
Surrogate Marker ◽  
Core Antigen ◽  
Viral Agent ◽  
Posttransfusion Hepatitis

Abstract The risk of hepatitis virus transmission from transfusions has declined dramatically from that of the 1940s when posttransfusion hepatitis (PTH) was first appreciated. Introduction of hepatitis B surface antigen screening and conversion to volunteer donors for whole-blood donations in the late 1960s and early 1970s led to substantial reduction in PTH cases. However, up to 10% of the recipients continued to develop PTH, most cases of which were attributed to an unknown non-A, non-B viral agent. Implementation of surrogate marker testing (i.e., alanine aminotransferase and anti-hepatitis B virus core antigen) for residual non-A, non-B hepatitis in the late 1980s reduced the per unit risk of PTH from 1 in 200 to about 1 in 400. Hepatitis C virus was discovered in 1989 and quickly was established as the causative agent of >90% of non-A, non-B PTH. Introduction of progressively improved antibody assays in the early 1990s reduced the risk of PTH due to hepatitis C virus to about 1 in 100 000. Although additional hepatitis viruses exist (e.g., hepatitis G virus), these appear to be minor contributors to clinical PTH, which has been virtually eradicated.

Evaluation of Antibodies to Hepatitis C Virus in a Long-Term Prospective Study of Posttransfusion Hepatitis Among Thalassemic Children

1993 ◽  
Vol 16 (4) ◽  
pp. 458-464 ◽  
Author(s):  
Maria Eliana Lai ◽  
Stefano De Virgilis ◽  
Francesca Argiolu ◽  
Patrizia Farci ◽  
Anna P. Mazzoleni ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Prospective Study ◽  
Posttransfusion Hepatitis
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