Clinical Program of Breast Surveillance by Means of Echopalpation: Results from January 1985 to May 1992

2015 ◽  
pp. 51-62
Author(s):  
E. Dambrosio ◽  
A. Colombo ◽  
T. Rubino ◽  
G. Bordin
Keyword(s):  
Clinical Program

Abstract 5063: Cardiovascular Effects of Transdermal Testosterone in Postmenopausal Women

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
C Vitale ◽  
P Collins ◽  
G Marazzi ◽  
G Caminiti ◽  
I Lodhi ◽  
...  
Keyword(s):  
Risk Factors ◽  
Clinical Trials ◽  
Hormone Replacement ◽  
Cardiovascular Effects ◽  
Pooled Analysis ◽  
Phase Iii ◽  
Double Blind ◽  
Treatment Groups ◽  
Clinical Program ◽  
Large Phase

Testosterone Transdermal Patch (TTP) has been developed for the treatment of postmeno-pausal women (PMW) with hypoactive sexual desire disorder (HSDD). Since the cardiovascular (CV) effects of testosterone in women are still unclear we conducted a pooled analysis of the large phase III clinical program to evaluate the efficacy and safety of 300 μg/day TTP, alone or in association with hormone replacement therapy (HRT), versus placebo in surgical or natural PMW. Design & Methods: A total of 2795 women aged between 26 –70 years (mean age 52(SD=6.8) years) were included in 5 phase III randomized, double-blind, placebo-controlled clinical trials (treatment duration range 24 – 52 weeks) as part of the TTP Clinical program. 4 studies included PMW (natural and surgical, two each respectively) receiving HRT while 1 study was conducted without HRT, in either surgical or natural PMW. Women with known CV disorders were excluded from the studies. Changes from baseline in standard metabolic and CV risk factors were compared. The incidence of stroke, myocardial infarction (MI) and venous thromboembolism (VTE) alone or as a composite CV endpoint was assessed. Results: The 2795 PMW were randomized to receive either placebo (n=1297) or TTP (n=1498). Baseline mean BMI was 27 kg/m2 (SD=5.3 kg/m2) and 56% were naturally menopausal. The demographic and baseline parameters were similar among the treatment groups. No significant changes in CV risk factors (Total Cholesterol, Triglycerides, Insulin, Glucose, Systolic and Diastolic Blood Pressure) were detected during the study period, apart from a blunting of the increases in HDL-C by TTP at 24 and 52 weeks (Placebo 52-week mean change 2.59 mg/dl vs. TTP 52-week mean change 1.20 mg/dl, p<0.005) and of the decrease in LDL-C by TTP at 24 (p<0.05), but not at 52 weeks. During the double-blind (24 weeks), placebo-controlled period of the combined studies, 4 major CV events (2 MIs and 2 strokes) were reported in placebo patients and 3 (2 MIs and 1 stroke) in those receiving TTP. One VTE occurred in a patient receiving TTP and HRT. Conclusion: TTP therapy in these clinical trials did not adversely affect CV risk profile and did not change the risk of major CV events in these surgical and naturally PMW with or without concomitant HRT.

Developing a Health Care System for Children in Foster Care

2017 ◽  
Vol 19 (4) ◽  
pp. 621-628 ◽  
Author(s):  
Mary V. Greiner ◽  
Sarah J. Beal
Keyword(s):  
Health Care ◽  
Foster Care ◽  
Medical Center ◽  
Children In Foster Care ◽  
Traditional Health ◽  
Social Settings ◽  
Consultation Model ◽  
Traditional Health Care ◽  
Clinical Program ◽  
Comprehensive Health

In 2012, the Comprehensive Health Evaluations for Cincinnati’s Kids (CHECK) Center was launched at Cincinnati Children’s Hospital Medical Center to provide health care for over 1,000 children placed into foster care each year in the Cincinnati community. This consultation model clinical program was developed because children in foster care have been difficult to manage in the traditional health care setting due to unmet health needs, missing medical records, cumbersome state mandates, and transient and impoverished social settings. This case study describes the history and creation of the CHECK Center, demonstrating the development of a successful foster care health delivery system that is inclusive of all community partners, tailored for the needs and resources of the community, and able to adapt and respond to new information and changing systems.

The Establishment, Transfer, and Maintenance of Fluent Speech in 50 Stutterers Using Delayed Auditory Feedback and Operant Procedures

1974 ◽  
Vol 39 (1) ◽  
pp. 3-10 ◽  
Author(s):  
Bruce P. Ryan ◽  
Barbara Van Kirk
Keyword(s):  
Detailed Analysis ◽  
Auditory Feedback ◽  
Rehabilitation Center ◽  
Delayed Auditory Feedback ◽  
Fluent Speech ◽  
Speech Fluency ◽  
The Past ◽  
Clinical Program

Operant speech fluency techniques are being used in a clinical program in a rehabilitation center to treat people who stutter. Establishment, transfer, and maintenance programs are used. Delayed auditory feedback is commonly employed to produce the initial fluent speech. From more than 200 clients seen over the past four years, 50 recent clients were selected for a detailed analysis. The results indicate that the programs are effective in helping people of varying ages and stuttering severity to speak fluently. This was accomplished in relatively short periods (approximately 20 hours of therapy). The fluent speech of the clients has transferred to their environment and checks indicate that it has been maintained.

scholarly journals “University Law Clinics and their value in undertaking client-centred law reform to provide a voice for clients’ experiences”

2014 ◽  
Vol 12 ◽  
pp. 105 ◽  
Author(s):  
Liz Curran
Keyword(s):  
Legal System ◽  
Work Experience ◽  
Policy Development ◽  
Clinical Work ◽  
Law Reform ◽  
Public Confidence ◽  
Court Cases ◽  
Clinical Program ◽  
Case Work ◽  
The Law

<p>This article examines how a clinical program can enlarge on the benefits of case work experience of enabling students by adding a course component which engages the students in identifying systemic issues in their case work which can be used to inform work on law reform issues as part of assessment in the clinical programs. The clinical program discussed in this article, demonstrates that assessment can be broadened to enable students to critique the contexts within which client issues emerge. The added component to student case work requires students to develop and use further skills in research, analysis and the evaluation of issues emerging from case work and suggest considered solutions to improve the operation of the legal system. My experience of such an approach is that it deepens students understanding not just of the law and how it is applied to their case work but also the mechanics of the law, how laws are made and how they are influenced. Student lawyers also see the important role of lawyers as members of a profession in ensuring the legal system retains public confidence. A side effect of this extension of the clinical work beyond only client work, is that students become motivated and are more employable (as they leave the course not only with skills in interviewing, communicating, letter writing, applying the law and preparing court cases) with skills in policy development and submission writing.</p>

scholarly journals HBI-8000, HUYABIO Lead Clinical Program, Is a Selective Histone Deacetylase Inhibitor With Therapeutic Benefits in Leukemia and in Solid Tumors

2022 ◽  
Vol 11 ◽  
Author(s):  
Farbod Shojaei ◽  
Bob Goodenow ◽  
Gloria Lee ◽  
Fairooz Kabbinavar ◽  
Mireille Gillings
Keyword(s):  
Breast Cancer ◽  
Solid Tumors ◽  
Histone Deacetylase Inhibitor ◽  
Therapeutic Benefits ◽  
Current Review ◽  
Molecule Inhibitor ◽  
Deacetylase Inhibitor ◽  
Clinical Program ◽  
Class I Hdacs ◽  
Cancerous Cells

HBI-8000 is a small molecule inhibitor of class I HDACs and has been approved for the treatment of PTCL, ATL and, in combination with exemestane, in a subpopulation of breast cancer. Given the roles of HDACs in normal and cancerous cells, there are currently multiple clinical trials, by HUYABIO International, to test the efficacy of HBI-8000 in monotherapy or in combination settings in leukemias and in solid tumors. The current review is focused on the applications of HDACi HBI-8000 in cancer therapy and its potential in combination with DDR agents.

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