Cooperative Roles of Oocyte and Follicle in Ovarian Parthenogenesis and Teratocarcinogenesis in Mice: Evidence from Chimeric Mice

2015 ◽  
pp. 271-284
Author(s):  
Motoko Noguchi ◽  
Masahiro Sato ◽  
Noriko Mori ◽  
Masahito Hayashi ◽  
Moriaki Kusakabe
Keyword(s):  
Chimeric Mice

Efficacy of HDV mono-infection with genotype 1 and 3 in CRPISPR/Cas generated humanized NTCP mice compared to human liver chimeric mice

2018 ◽  
Vol 56 (01) ◽  
pp. E2-E89
Author(s):  
K Giersch ◽  
T Volz ◽  
J Kah ◽  
L Allweiss ◽  
A Lohse ◽  
...  
Keyword(s):  
Human Liver ◽  
Genotype 1 ◽  
Chimeric Mice

scholarly journals Intermittent rolling is a defect of the extravasation cascade caused by Myosin1e-deficiency in neutrophils

2019 ◽  
Vol 116 (52) ◽  
pp. 26752-26758 ◽  
Author(s):  
Eduardo Vadillo ◽  
Sandra Chánez-Paredes ◽  
Hilda Vargas-Robles ◽  
Idaira María Guerrero-Fonseca ◽  
Ramón Castellanos-Martínez ◽  
...  
Keyword(s):  
Vascular Endothelium ◽  
Actin Polymerization ◽  
Inflammatory Diseases ◽  
Chimeric Mice ◽  
Rolling Velocity ◽  
Chronic Inflammatory Diseases ◽  
Neutrophil Extravasation ◽  
Cytoskeletal Dynamics ◽  
Adhesive Interactions ◽  
Deficient Mice

Neutrophil extravasation is a migratory event in response to inflammation that depends on cytoskeletal dynamics regulated by myosins. Myosin-1e (Myo1e) is a long-tailed class-I myosin that has not yet been studied in the context of neutrophil–endothelial interactions and neutrophil extravasation. Intravital microscopy of TNFα-inflamed cremaster muscles in Myo1e-deficient mice revealed that Myo1e is required for efficient neutrophil extravasation. Specifically, Myo1e deficiency caused increased rolling velocity, decreased firm adhesion, aberrant crawling, and strongly reduced transmigration. Interestingly, we observed a striking discontinuous rolling behavior termed “intermittent rolling,” during which Myo1e-deficient neutrophils showed alternating rolling and jumping movements. Surprisingly, chimeric mice revealed that these effects were due to Myo1e deficiency in leukocytes. Vascular permeability was not significantly altered in Myo1e KO mice. Myo1e-deficient neutrophils showed diminished arrest, spreading, uropod formation, and chemotaxis due to defective actin polymerization and integrin activation. In conclusion, Myo1e critically regulates adhesive interactions of neutrophils with the vascular endothelium and neutrophil extravasation. Myo1e may therefore be an interesting target in chronic inflammatory diseases characterized by excessive neutrophil recruitment.

scholarly journals Chimeric Mice with Humanized Livers: A Unique Tool for in Vivo and in Vitro Enzyme Induction Studies

2013 ◽  
Vol 15 (1) ◽  
pp. 58-74 ◽  
Author(s):  
Masakazu Kakuni ◽  
Chihiro Yamasaki ◽  
Asato Tachibana ◽  
Yasumi Yoshizane ◽  
Yuji Ishida ◽  
...  
Keyword(s):  
Enzyme Induction ◽  
Chimeric Mice

Steroid metabolism in chimeric mice with humanized liver

2009 ◽  
Vol 1 (11-12) ◽  
pp. 531-537 ◽  
Author(s):  
Leen Lootens ◽  
Peter Van Eenoo ◽  
Philip Meuleman ◽  
Oscar J. Pozo ◽  
Pieter Van Renterghem ◽  
...  
Keyword(s):  
Steroid Metabolism ◽  
Chimeric Mice

Cerebellar Purkinje cells provide target support over a limited spatial range: evidence from lurcher chimeric mice

1991 ◽  
Vol 64 (1-2) ◽  
pp. 87-94 ◽  
Author(s):  
Michael W. Vogel ◽  
Mark McInnes ◽  
Hadi Shojaeian Zanjani ◽  
Karl Herrup
Keyword(s):  
Purkinje Cells ◽  
Chimeric Mice ◽  
Spatial Range ◽  
Cerebellar Purkinje Cells

Expression of IgH Promoter/Enhancer Ly-1 Transgene in Hematopoietic Chimeric Mice Generated by Embryonic Stem Cell Line

1990 ◽  
Vol 93 (2-3) ◽  
pp. 155-164 ◽  
Author(s):  
Takayuki Sumida ◽  
Toshiro Maeda ◽  
Takao Koike ◽  
Hisao Tomioka ◽  
Sho Yoshida ◽  
...  
Keyword(s):  
Stem Cell ◽  
Embryonic Stem Cell ◽  
Cell Line ◽  
Embryonic Stem Cell Line ◽  
Embryonic Stem ◽  
Chimeric Mice ◽  
Stem Cell Line

Predictability of plasma concentration–time curves in humans using single-species allometric scaling of chimeric mice with humanized liver

Xenobiotica ◽  
2015 ◽  
Vol 45 (7) ◽  
pp. 605-614 ◽  
Author(s):  
Seigo Sanoh ◽  
Yoichi Naritomi ◽  
Mami Fujimoto ◽  
Koya Sato ◽  
Akio Kawamura ◽  
...  
Keyword(s):  
Plasma Concentration ◽  
Allometric Scaling ◽  
Single Species ◽  
Chimeric Mice ◽  
Concentration Time
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