Role of Vitamin E and Lipid Peroxidation in Atherosclerosis

Vitamin E ◽  
2015 ◽  
pp. 243-247
Author(s):  
Sampath Parthasarathy
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin E

scholarly journals Role of vitamin E in glutathione-induced oxidant stress: methemoglobin, lipid peroxidation, and hemolysis

1977 ◽  
Vol 18 (5) ◽  
pp. 635-644
Author(s):  
N R Brownlee ◽  
J J Huttner ◽  
R V Panganamala ◽  
D G Cornwell
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin E ◽  
Oxidant Stress

scholarly journals Sex Differences in Postischemic Neuronal Necrosis in Gerbils

1991 ◽  
Vol 11 (2) ◽  
pp. 292-298 ◽  
Author(s):  
Edward D. Hall ◽  
Kay E. Pazara ◽  
Kelley L. Linseman
Keyword(s):  
Lipid Peroxidation ◽  
Cerebral Cortex ◽  
Vitamin E ◽  
Protective Efficacy ◽  
Neuronal Population ◽  
Mongolian Gerbils ◽  
Neuronal Necrosis ◽  
Male And Female ◽  
Endogenous Estrogen

Twenty-four hour postischemic neuronal necrosis was compared in male vs. female Mongolian gerbils subjected to a 3-h period of severe incomplete hemispheric ischemia produced by unilateral carotid occlusion. The incidence of stroke-prone males was 42.9% versus 26.7% for the females. Among the stroke-prone animals, the males displayed significantly greater neuronal necrosis at 24 h after ischemia compared to the females in the cerebral cortex and CA, region of the hippocampus. In the CA, region of the stroke-prone males, only 2.0% of the normal neuronal population remained by 24 h compared to 36.8% in the stroke-prone females (p < 0.02). In the cerebral cortex, the males had only 19.9% of normal versus 58.2% in the females (p < 0.05). In a second series of mechanistic experiments, no differences in cortical blood flow (CBF) were disclosed between preselected male and female stroke-prone animals before, during, or for 2 h after ischemia. As with the CBF, the extent of cortical extracellular hypocalcia during ischemia did not differ significantly. However, the degree of postischemic recovery of cortical extracellular calcium was significantly better in the females from 30 min to 2 h after reperfusion. In the same experiments, hemispheric vitamin E levels were measured at the 2 h time point as an index of postischemic brain lipid peroxidation. No difference in baseline vitamin E levels was observed between male and female sham-operated gerbils. In the males subjected to 3 h of ischemia plus 2 h of reperfusion, the hemispheric vitamin E decreased by 43.5% compared to the sham-operated males. In contrast, the females displayed only a 4.2% decline (p < 0.05 versus males). Previous studies showing the protective efficacy of antioxidants in this model have suggested an important role of oxygen radical-induced lipid peroxidation. Thus, it is proposed that the lesser ischemic vulnerability of females may be based upon an antioxidant effect of endogenous estrogen. Indeed, estrogen was found to be a more potent inhibitor of iron-catalyzed lipid peroxidation in brain tissue than vitamin E.

Mécanisme moléculaire de l'effet protecteur de la vitamine E dans l'athérosclérose

2002 ◽  
Vol 80 (7) ◽  
pp. 662-669 ◽  
Author(s):  
Abdelouahed Khalil
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin E ◽  
Vascular Diseases ◽  
Epidemiologic Studies ◽  
Low Density Lipoproteins ◽  
Alpha Tocopherol ◽  
Low Density ◽  
Prooxidant Effect

Oxidation of low-density lipoproteins constitutes the first step of a very complex process leading to atherosclerosis. Vitamin E, and principally alpha-tocopherol, is considered as the principal inhibitor of lipid peroxidation. Some studies showed the beneficial role of vitamin E in the prevention and reduction of atherosclerosis and its associated pathologies. However, other in vitro studies advance a prooxidant role of vitamin E. The results of the epidemiologic studies are difficult to generalize without taking account of the clinical randomized tests. In this work, we reviewed the principal studies devoted to the role of vitamin E and discussed the assumption of a prooxidant effect of this molecule.Key words: vitamin E, low-density lipoproteins (LDL), lipid peroxidation, cardio-vascular diseases.

Hypoxia-induced necrotizing enterocolitis in the immature rat: The role of lipid peroxidation and management by vitamin E

1995 ◽  
Vol 30 (10) ◽  
pp. 1416-1419 ◽  
Author(s):  
Hamit Okur ◽  
Mustafa Küçükaydin ◽  
Kader Köse ◽  
Olgun Kontaş ◽  
Pakize Doǧan ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin E ◽  
Necrotizing Enterocolitis ◽  
Immature Rat

The effects of diazinon on lipid peroxidation and antioxidant enzymes in rat heart and ameliorating role of vitamin E and vitamin C

2006 ◽  
Vol 22 (6) ◽  
pp. 455-461 ◽  
Author(s):  
O. Akturk ◽  
H. Demirin ◽  
R. Sutcu ◽  
N. Yilmaz ◽  
H. Koylu ◽  
...  
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Enzymes ◽  
Vitamin E ◽  
Vitamin C ◽  
Rat Heart

scholarly journals The Role of Route of Vitamin E Administration on the Plasma Antioxidant Activity and Lipid Peroxidation in Newborn Calves

2008 ◽  
Vol 103 (5) ◽  
pp. 414-418 ◽  
Author(s):  
Mohammad Reza Mokhber-Dezfouli ◽  
Edris Rahimikia ◽  
Farzad Asadi ◽  
Mohammad Gholi Nadalian
Keyword(s):  
Lipid Peroxidation ◽  
Antioxidant Activity ◽  
Vitamin E ◽  
Newborn Calves ◽  
Plasma Antioxidant

scholarly journals The Role of Excessive Amounts of Dietary Copper and Vitamin E in Lipid Peroxidation in Tissues of the Pig

1994 ◽  
Vol 65 (9) ◽  
pp. 856-861
Author(s):  
Kyoko HODATE ◽  
Tatsuo HAMADA ◽  
Shozi MAEDA
Keyword(s):  
Lipid Peroxidation ◽  
Vitamin E ◽  
Dietary Copper
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