Alcohol Abuse, Free Radicals, and Vitamin E

Vitamin E ◽  
2015 ◽  
pp. 177-186
Author(s):  
Tateo Kawase ◽  
Takashi Harada
Keyword(s):  
Free Radicals ◽  
Vitamin E ◽  
Alcohol Abuse

Evaluation of the Local Effects of Vitamin E ( E-Mousse®) on Free Radicals in Diabetic Microangiopathy: A Randomized, Controlled Trial

Angiology ◽  
2003 ◽  
Vol 54 (4) ◽  
pp. 415-421 ◽  
Author(s):  
I. Ruffini ◽  
G. Belcaro ◽  
M.R. Cesarone ◽  
G. Geroulakos ◽  
A. Di Renzo ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Free Radicals ◽  
Vitamin E ◽  
Controlled Trial ◽  
Diabetic Microangiopathy ◽  
Local Effects ◽  
Randomized Controlled

scholarly journals ANTIOXIDANT ACTIVITY IN LEAVES OF SESBANIA GRANDIFLORA (L.) PERS.

2018 ◽  
Vol 11 (1) ◽  
pp. 116
Author(s):  
Pradeesh S ◽  
Swapna T S
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Superoxide Dismutase ◽  
Free Radicals ◽  
Vitamin E ◽  
Monodehydroascorbate Reductase ◽  
Enzymatic Antioxidants ◽  
Good Source ◽  
Sesbania Grandiflora ◽  
The Family

Objective: The main aim of this study was to evaluate the antioxidants present in Sesbania grandiflora (L.) Pers. belongs to the family Fabaceae.Methods: Fresh samples were used for the analysis of antioxidants such as total phenol, carotenoids, Vitamin-A, Vitamin-C, Vitamin-E, peroxidase (POD), catalase (CAT), superoxide dismutase (SOD), ascorbate peroxidase, monodehydroascorbate reductase, and glutathione reductase by standard estimation methods.Results: Present studies revealed that this wild leafy plant has numerous antioxidant factors that destroying the free radicals that damage the cells.Conclusion: S. grandiflora contain many enzymatic and non-enzymatic antioxidants and could be a good source of dietary antioxidants which play an important role in the prevention of diseases associated with oxidative stress.

In Vitro Modulation of Cellular Immunity with Antioxidants in Patients with Thalassemia Major.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 3775-3775
Author(s):  
Belkis Atasever ◽  
Serap Erdem Kuruca ◽  
Zeynep Karakas ◽  
Leyla Agaoglu
Keyword(s):  
T Cells ◽  
Free Radicals ◽  
Vitamin E ◽  
Vitamin C ◽  
Iron Overload ◽  
Healthy Volunteers ◽  
Nk Cell ◽  
Cell Activity ◽  
Nk Activity

Abstract Immunological disturbances have been reported in thalassemia and the possibility has been raised that these may be consequences of blood transfusion and iron overload. These disturbances are augmentation of the number of supressor T cells (CD8), decreased number and activity of helper T cells (CD4) and impaired activity of NK (natural killer) cells. Iron overload causes toxic tissue changes through the release of free radicals and induces oxidative stress. According to Fenton and Haber-Weiss reactions, iron plays a catalytic role occuring hydroxyl radicals (OH*) which are very reactive free radicals. Antioxidants, like vitamin E, vitamin C and selenium, may modulate oxidative damage. In the present study; firstly, normal lymphocytes mitogen responses and NK activity were investigated by colorimetric MTT test in 26 thalassemia patients and 10 healthy volunteers as control. Secondly, lymphocytes were incubated with vitamin E ( 150, 50, 15 mg/ml), vitamin C (200, 100, 20mg/ml) and selenium (10−5, 10−6, 10−7 M). Finally, lymphocytes mitogen responses and NK activity are investigated. The results were statistically analyzed comparing with controls and healthy volunteers. It was found decreased NK activity of thalassemia patients in comparison with healthy volunteers. The concentration of 10−7 M of selenium enhanced NK activity at the E:T (effector/target) ratio of 50:1 The concentration of 200 mg/ml of vitamin C enhanced NK activity at the E:T ratio of 10:1, 25:1 and 50:1. However, vitamin E decreased NK activity of both thalassemia patients and healhty volunteers. The concentration of 50 mg/ml vitamin E decreased NK activity at the E:T ratio of 5:1 in thalassemia patients and the concentration of 15 mg/ml of vitamin E decreased NK activity at the E:T ratio of 5:1 in healhty volunteers. It was not found any differences between thalassemia patients and healthy volunteers in lymphocytes mitogen responses. The concentration of 200 mg/ml of vitamin C decreased lymphocytes mitogen response against PHA. In conclusion, we suggest that vitamin C and selenium supplementation are required in patients with thalassemia for augmentation of NK cell activity.

Vitamin E-Coated Tympanostomy Tube Insertion Decreases the Quantity of Free Radicals in Tympanic Membrane

2006 ◽  
Vol 116 (1) ◽  
pp. 140-143 ◽  
Author(s):  
C??neyd ??neri ◽  
Murat Sari ◽  
J??lide Akbo??a ◽  
Meral Y??ksel
Keyword(s):  
Free Radicals ◽  
Vitamin E ◽  
Tympanic Membrane ◽  
Tympanostomy Tube ◽  
Tube Insertion

scholarly journals Alpha-tocopherol inhibits pore formation in oxidized bilayers

2017 ◽  
Vol 19 (8) ◽  
pp. 5699-5704 ◽  
Author(s):  
Phansiri Boonnoy ◽  
Mikko Karttunen ◽  
Jirasak Wong-ekkabut
Keyword(s):  
Free Radicals ◽  
Vitamin E ◽  
Crucial Role ◽  
Pore Formation ◽  
Biological Membranes ◽  
Alpha Tocopherol

Alpha-tocopherols (α-toc; vitamin E) play a crucial role in protecting biological membranes from free radicals.

scholarly journals Comparison of Oxidant-Antioxidant Status in Patients with Vitiligo and Healthy Population

2015 ◽  
Vol 12 (2) ◽  
pp. 132-136 ◽  
Author(s):  
S Agrawal ◽  
A Kumar ◽  
TK Dhali ◽  
SK Majhi
Keyword(s):  
Oxidative Stress ◽  
Free Radicals ◽  
Vitamin E ◽  
Vitamin C ◽  
Control Group ◽  
Healthy Population ◽  
Significant Difference ◽  
Destruction Of Melanocytes ◽  
And Control

Background Vitiligo is a well-recognized pigmentary disorder of the skin and /or mucous membrane characterized by circumscribed ivory or chalky white macules devoid of identifiable melanocytes. The pathogenesis of vitiligo is complex and still not well understood. According to autocytotoxic hypothesis, oxidative stress has been suggested to be the initial pathogenic event in melanocyte degeneration. The role of free radicals and oxidative damage in the pathophysiology of vitiligo has been documented in recent studies.Objective To evaluate the role of oxidative stress in patients with vitiligo and of healthy controls by measuring levels of the oxidant malondialdehyde (MDA) and antioxidants vitamin C and vitamin E in serum and catalase (CAT) in erythrocytes.Method A total of 80 clinically diagnosed cases of vitiligo and 80 control subjects were included in the study to assess the activity of MDA, vitamin C and vitamin E in serum and CAT in erythrocytes of patients and controls by using the spectrophotometric assay.Result There was statistically significant increase in the levels of MDA in patients with vitiligo compared to the control group (p<0.001). No significant difference was found in the levels of vitamin C (p=0.411) and vitamin E (p=0.771) between the patients with vitiligo and control group. The levels of CAT in the vitiligo patients were found to be significantly lower than those of controls (p<0.001).Conclusion Increased oxidative stress and decreased catalase have been observed in vitiligo patients and the data suggesting that the free radicals may be involved in the destruction of melanocytes or dysregulation of melanogenesis.Kathmandu University Medical Journal Vol.12(2) 2014: 132-136

scholarly journals Skeletal muscle ischemia and reperfusion in rats increase lipid peroxidation in rats

2004 ◽  
Vol 19 (5) ◽  
pp. 578-581 ◽  
Author(s):  
Carlos Eli Piccinato ◽  
Armando De Domenico Jr ◽  
Alceu Afonso Jordão Jr ◽  
Helio Vannucchi
Keyword(s):  
Skeletal Muscle ◽  
Lipid Peroxidation ◽  
Free Radicals ◽  
Vitamin E ◽  
Ischemia Reperfusion ◽  
Ischemia And Reperfusion ◽  
Muscle Ischemia ◽  
Increase Lipid Peroxidation ◽  
Deficient Group

PURPOSE: To determine the effects of 30 minutes of ischemia followed by 30 minutes of reperfusion in skeletal muscle of rats receiving three different diets (supplemented, normal and vitamin E deficient) on lipoperoxidation (LP). METHODS: LP measured by TBARS levels, and plasma and hepatic concentrations of vitamin E measured by HPLC. RESULTS: The deficient group presented higher lipoperoxidation levels in muscle compared to the control and supplemented groups. CONCLUSION: Supplementation with vitamin E decrease the free radicals production in ischemia/reperfusion in skeletal muscle of rats.

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