Ranking of Topical Glucocorticoids

2015 ◽  
pp. 89-96 ◽  
Author(s):  
Eric W. Smith ◽  
John M. Haigh
Keyword(s):  
Topical Glucocorticoids

Knemometry in children with atopic dermatitis treated with topical glucocorticoids.

1998 ◽  
Vol 15 (1) ◽  
pp. 7-11 ◽  
Author(s):  
C Heuck ◽  
T Ternowitz ◽  
T Herlin ◽  
OD Wolthers
Keyword(s):  
Atopic Dermatitis ◽  
Topical Glucocorticoids

scholarly journals Glucocorticoid Receptor Beta and Its Prognostic Value on Treatment Response in Chronic Vulvar Dermatitis

2021 ◽  
pp. 1-8
Author(s):  
Valerie Bernays ◽  
Mariusz Pawel Kowalewski ◽  
Ioannis Dedes ◽  
Katrin Kerl French ◽  
Daniel Fink ◽  
...  
Keyword(s):  
Cohort Study ◽  
Glucocorticoid Receptor ◽  
Treatment Response ◽  
Retrospective Cohort ◽  
Prognostic Value ◽  
Biological Data ◽  
Topical Glucocorticoids ◽  
Prevalent Disease ◽  
Glucocorticoid Receptor Beta ◽  
Receptor Beta

<b><i>Background:</i></b> Chronic vulvar dermatitis (CVD) is the most prevalent disease in gynecologic dermatology. The treatment mainly depends on topical glucocorticoids (TGC) but is challenged by insufficient treatment response. On a histological level, the upregulation of the glucocorticoid receptor β (GRβ), an inhibitor of the active glucocorticoid receptor α (GRα), is discussed as mechanism of glucocorticoid insensitivity. <b><i>Objectives:</i></b> To analyze whether the expression of GRβ protein at baseline in keratinocytes may predict responsiveness to TGC in patients with CVD. <b><i>Methods:</i></b> In this retrospective cohort study, clinical and biological data of 25 women with a histological diagnosis of chronic vulvar eczema were analyzed. Randomization was done according to the responsiveness to TGC treatment (responsive vs. nonresponsive). Clinical data and the expression of GRβ in the immunohistochemical stained biopsies were examined. <b><i>Results:</i></b> Fifty-two percent of women with CVD were nonresponsive to TGC. GRβ was abundantly expressed in the cytoplasma of keratinocytes of the vulvar epithelium, but no difference in the level of expression was found among GC responsive and nonresponsive patients in the semiquantitative (<i>p</i> = 0.376) and quantitative analysis (<i>p</i> = 0.894). <b><i>Conclusion:</i></b> GRβ is highly expressed in keratinocytes of the vulvar epidermis affected by CVD, but GRβ expression was not increased in patients nonresponsive to TGC compared to responsive patients. Thus, the failure mechanism in nonresponders still remains to be elucidated.

scholarly journals Usage of 0.4% sodium hyaluronate in complex treatment of pediatric patients with dry eye syndrome against the background of allergic diseases of the organ of vision

2021 ◽  
Vol 9 (2) ◽  
pp. 21-24
Author(s):  
L.S. Vasilyeva ◽  
O.V. Nesterenko ◽  
K.A. Rylkova
Keyword(s):  
Anterior Chamber ◽  
Dry Eye ◽  
Pediatric Patients ◽  
Sodium Hyaluronate ◽  
Allergic Diseases ◽  
Dry Eye Syndrome ◽  
Control Group ◽  
Film Rupture ◽  
Topical Glucocorticoids

Background. In recent years, the prevalence of allergic diseases of the anterior chamber of the eye has increased. They are often accompanied by the development of dry eye syndrome, which can complicate their course. Therefore, it is important to take a comprehensive approach to their diagnosis and treatment. The purpose was to study the effectiveness of 0.4% sodium hyaluronate (Gilays) in children with dry eye syndrome on the background of allergic diseases of the conjunctiva. Materials and methods. The study involved 42 patients (84 eyes) aged 3 to 18 years, who were examined and treated on the basis of Regional Eye Clinic. Patients were treated with local H-1 histamine blockers twice a day for 14 days, f necessary — with topical glucocorticoids by the scheme for 12 days. In the first group (21 patients, 42 eyes), the main treatment was added with the drugs containing 0.2% sodium hyaluronate, used topically 4 times a day for 14 days. In the second group (21 patients/42 eyes), 0.4% sodium hyaluronate (Gilays) was added to the treatment regimen. H-1 histamine blockers were not used systemically. Before starting therapy and 2 weeks later, the following values were evaluated: the changes in the anterior chamber of the eye using biomicroscopy, determination of lacrimal film rupture time, Schirmer 1 test, questionnaire. Conclusions. The use of sodium hyaluronate in the complex therapy of dry eye syndrome in allergic eye diseases is quite effective. The use of 0.4% sodium hyaluronate was more effective compared to the control group. It is advisable to use a questionnaire to communicate with the child, but it is necessary to refine the form of questions to eliminate as much as possible the subjectivity of the data.

Topical glucocorticoids inhibit neurogenic inflammation: involvement of lipocortin 1

1995 ◽  
Vol 283 (1-3) ◽  
pp. 193-198 ◽  
Author(s):  
A. Ahluwalia ◽  
P. Newbold ◽  
S.D. Brain ◽  
R.J. Flower
Keyword(s):  
Neurogenic Inflammation ◽  
Topical Glucocorticoids

scholarly journals Extramammary Paget's Disease: A Case Report

2020 ◽  
Vol 8 (1) ◽  
pp. 83-85
Author(s):  
Anita Shah ◽  
Yogesh Poudel ◽  
Anuj Poudel
Keyword(s):  
Paget’S Disease ◽  
Paget's Disease ◽  
Extramammary Paget’S Disease ◽  
Erythematous Plaque ◽  
Eosinophilic Cytoplasm ◽  
Topical Glucocorticoids ◽  
Atypical Cells ◽  
History Of ◽  
White Scale ◽  
Extramammary Paget's Disease

A 60- year-old man presented with four year history of a non- healing rash. The rash was pruritic and painless. He had previously been treated empirically with oral and topical antibiotics, topical antifungal agents, and topical glucocorticoids without improvement. The physical examination revealed an erythematous plaque with superficial white scale affecting the skin of the groin and scrotum. Skin biopsy and histopathology revealed epidermal infiltration by large atypical cells that had eosinophilic cytoplasm and prominent nucleoli, findings were consistent with Pagets disease. Extramammary Paget's disease (EMPD) is an intraepithelial adenocarcinoma that is sometimes misdiagnosed as dermatitis clinically. It most commonly involves the vulva and in perianal skin, scrotum, penis and axilla. The patient was kept on regular surveillance. The patient has increased intensity of itching and increase in size of lesion after six months of diagnosis.

scholarly journals Mycosis Fungoides: Case Report and Literature Review

2014 ◽  
Vol 7 ◽  
pp. CCRep.S15724 ◽  
Author(s):  
Akinsegun A. Akinbami ◽  
Bodunrin I. Osikomaiya ◽  
Sarah O. John-Olabode ◽  
Adewumi A. Adediran ◽  
Olajumoke Osinaike ◽  
...  
Keyword(s):  
Case Report ◽  
T Cell ◽  
Literature Review ◽  
B Cell ◽  
Mycosis Fungoides ◽  
Cell Lymphoma ◽  
Cutaneous T Cell Lymphoma ◽  
Cutaneous Lymphomas ◽  
Nigerian Woman ◽  
Topical Glucocorticoids

Mycosis fungoides (MF), also known as Alibert-Bazin syndrome or granuloma fungoides, is the most common form of cutaneous T-cell lymphoma. Cutaneous lymphomas are an uncommon, heterogeneous group of non-Hodgkin lymphomas (NHLs) of T- and B-cell origin where the skin is the primary organ of involvement. This is a case of a 60-year-old Nigerian woman, who was diagnosed and managed as a case of chronic dermatitis but further investigations confirmed a diagnosis of MF; she was thereafter managed with topical glucocorticoids/chemotherapy and improved on these treatments. We make a plea for better awareness of the disease among physicians and pathologists in Africa.

Hydrocortisone Aceponate Activity and Benefit/Risk Ratio in Relation to Reference Topical Glucocorticoids

2010 ◽  
Vol 23 (4) ◽  
pp. 177-182 ◽  
Author(s):  
J. Wohlrab ◽  
G.M. Beck ◽  
R.H.H. Neubert ◽  
U. Sischka ◽  
B. Kreft
Keyword(s):  
Risk Ratio ◽  
Topical Glucocorticoids
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