Leukocyte-Dependent and -Independent Hepatic Microvascular Injury during Reperfusion after Warm Ischemia

2015 ◽  
pp. 139-151 ◽  
Author(s):  
M. G. Clemens ◽  
Karen Chun ◽  
Elizabeth Miescher ◽  
D. Jones ◽  
J. Zhang
Keyword(s):  
Warm Ischemia ◽  
Microvascular Injury

1855: Laparoscopic Donor Nephrectomy: Impact of Warm Ischemia on Allograft Function

2004 ◽  
Vol 171 (4S) ◽  
pp. 490-490
Author(s):  
Mahesh C. Gael ◽  
J. Feng ◽  
David A. Goldfarb ◽  
lnderbir S. Gill
Keyword(s):  
Warm Ischemia ◽  
Donor Nephrectomy ◽  
Laparoscopic Donor Nephrectomy ◽  
Allograft Function

V218: Eliminating Knot Tying During Warm Ischemia Time for Laparoscopic Partial Nephrectomy: The Video

2004 ◽  
Vol 171 (4S) ◽  
pp. 57-58
Author(s):  
Marcelo A. Orvieto ◽  
Gary W. Chien ◽  
R. Matthew Galocy ◽  
Mitchell H. Sokoloff ◽  
Gregory P. Zagaja ◽  
...  
Keyword(s):  
Partial Nephrectomy ◽  
Warm Ischemia ◽  
Warm Ischemia Time ◽  
Laparoscopic Partial Nephrectomy ◽  
Knot Tying ◽  
Ischemia Time

Measurement of the Platelet Response to Laser- induced Microvascular Injury

1974 ◽  
Vol 32 (02/03) ◽  
pp. 704-713 ◽  
Author(s):  
F. N McKenzie ◽  
K.-E Arfors ◽  
N. A Matheson
Keyword(s):  
Inhibitory Effect ◽  
Microvascular Blood Flow ◽  
Platelet Response ◽  
High Concentration ◽  
Platelet Activity ◽  
Microvascular Injury ◽  
Arterial Blood ◽  
Proximal Site ◽  
Adenosine Phosphates

SummaryA study has been made of the biochemical factors underlying the platelet response to laser-induced microvascular injury. A platelet aggregating substance is produced at sites of laser-induced injury which markedly stimulates platelet activity at a site of injury inflicted a short distance downstream. Distal sites of injury are not similarly influenced if the distance between the injuries is increased or if the proximal site no longer shows platelet-stimulating activity. The stimulating effect of an adjacent proximal injury on platelet activity at a distal site is inhibited by local intra-arterial infusion of adenosine. Measurements of arterial blood pressure and microvascular blood flow velocity during adenosine infusion showed that its inhibitory effect on platelet activity is largely independent of its vasodilator properties. The effect of infusion of different adenosine phosphates (AMP, ADP, ATP) was also studied. Very small amounts of ADP markedly stimulated platelet activity and the emboli formed were similar to those normally produced at sites of laser injury. At high concentration AMP inhibited while ATP stimulated platelet activity in vivo. The results emphasise the fundamental role of ADP as a mediator of the platelet response at sites of laser- induced microvascular injury.

Microvascular Injury of the Peribiliary Plexus Associated with Transarterial Chemoembolization: A Study of Surgical Specimens

2006 ◽  
Vol 55 (5) ◽  
pp. 471
Author(s):  
Won Kyu Park ◽  
Young Kyung Bae ◽  
Tae Yoon Hwang ◽  
Jae Ho Cho ◽  
Jay Chun Chang ◽  
...  
Keyword(s):  
Transarterial Chemoembolization ◽  
Microvascular Injury

Therapy Against Reperfusion-induced Microvascular Injury

2013 ◽  
Vol 19 (25) ◽  
pp. 4586-4596 ◽  
Author(s):  
Isabella Tritto ◽  
Cinzia Zuchi ◽  
Serena Vitale ◽  
Giuseppe Ambrosio
Keyword(s):  
Microvascular Injury

CRITICAL ISSUES IN THE USE OF VASOACTIVE SUBSTANCES TO ASSESS LUNG MICROVASCULAR INJURY

1982 ◽  
Vol 384 (1 Mechanisms of) ◽  
pp. 435-457 ◽  
Author(s):  
S. Alex Stalcup ◽  
G. M. Turino ◽  
Robert B. Mellins
Keyword(s):  
Microvascular Injury ◽  
Vasoactive Substances ◽  
Critical Issues

Selective cyclooxygenase-2 inhibitor ameliorates warm ischemia-reperfusion injury of the canine liver

2001 ◽  
Vol 33 (1-2) ◽  
pp. 862 ◽  
Author(s):  
Y Sunose ◽  
I Takeyoshi ◽  
S Ohwada ◽  
H Tsutsumi ◽  
S Iwazaki ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Warm Ischemia ◽  
Cyclooxygenase 2

Beclin-1 overexpression regulates NLRP3 activation by promoting TNFAIP3 in microvascular injury following myocardial reperfusion

2021 ◽  
Vol 84 ◽  
pp. 110008
Author(s):  
Wenjing Sun ◽  
Shujuan Dong ◽  
Hongquan Lu ◽  
Nan Wang ◽  
Yu Zhao ◽  
...  
Keyword(s):  
Myocardial Reperfusion ◽  
Beclin 1 ◽  
Microvascular Injury

scholarly journals Mild traumatic brain injury induces microvascular injury and accelerates Alzheimer-like pathogenesis in mice

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Yingxi Wu ◽  
Haijian Wu ◽  
Jianxiong Zeng ◽  
Brock Pluimer ◽  
Shirley Dong ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Vascular Connection ◽  
Microvascular Injury ◽  
Amyloid Pathology ◽  
Blood Flow Reduction ◽  
5Xfad Mouse ◽  
Time Courses ◽  
5Xfad Mice ◽  
Pericyte Loss

Abstract Introduction Traumatic brain injury (TBI) is considered as the most robust environmental risk factor for Alzheimer’s disease (AD). Besides direct neuronal injury and neuroinflammation, vascular impairment is also a hallmark event of the pathological cascade after TBI. However, the vascular connection between TBI and subsequent AD pathogenesis remains underexplored. Methods In a closed-head mild TBI (mTBI) model in mice with controlled cortical impact, we examined the time courses of microvascular injury, blood–brain barrier (BBB) dysfunction, gliosis and motor function impairment in wild type C57BL/6 mice. We also evaluated the BBB integrity, amyloid pathology as well as cognitive functions after mTBI in the 5xFAD mouse model of AD. Results mTBI induced microvascular injury with BBB breakdown, pericyte loss, basement membrane alteration and cerebral blood flow reduction in mice, in which BBB breakdown preceded gliosis. More importantly, mTBI accelerated BBB leakage, amyloid pathology and cognitive impairment in the 5xFAD mice. Discussion Our data demonstrated that microvascular injury plays a key role in the pathogenesis of AD after mTBI. Therefore, restoring vascular functions might be beneficial for patients with mTBI, and potentially reduce the risk of developing AD.

scholarly journals Human liver stem cell‐derived extracellular vesicles reduce injury in a model of normothermic machine perfusion of rat livers previously exposed to a prolonged warm ischemia

2021 ◽  
Vol 34 (9) ◽  
pp. 1607-1617
Author(s):  
Nicola De Stefano ◽  
Victor Navarro‐Tableros ◽  
Dorotea Roggio ◽  
Alberto Calleri ◽  
Federica Rigo ◽  
...  
Keyword(s):  
Stem Cell ◽  
Extracellular Vesicles ◽  
Human Liver ◽  
Warm Ischemia ◽  
Machine Perfusion ◽  
Normothermic Machine Perfusion ◽  
Rat Livers
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