Role of the Immune Response in Visna, a Lentiviral Central Nervous System Disease of Sheep

2015 ◽  
pp. 183-195 ◽  
Author(s):  
Gudmundur Georgsson ◽  
Sigurbj�rg Torsteinsd�ttir ◽  
Gudmundur P�tursson ◽  
P�ll A. P�lsson ◽  
�lafur S. Andr�sson
Keyword(s):  
Central Nervous System ◽  
Immune Response ◽  
Nervous System ◽  
Central Nervous System Disease ◽  
Nervous System Disease ◽  
System Disease

scholarly journals Immune Response-Mediated Protection of Adult but Not Neonatal Mice from Neuron-Restricted Measles Virus Infection and Central Nervous System Disease

1999 ◽  
Vol 73 (3) ◽  
pp. 1795-1801 ◽  
Author(s):  
Diane M. P. Lawrence ◽  
Melinda M. Vaughn ◽  
Alec R. Belman ◽  
Joan S. Cole ◽  
Glenn F. Rall
Keyword(s):  
Central Nervous System ◽  
Immune Response ◽  
Nervous System ◽  
Neurological Disease ◽  
Measles Virus ◽  
Central Nervous System Disease ◽  
Nervous System Disease ◽  
Antiviral Immune Response ◽  
System Disease ◽  
The Brain

ABSTRACT In many cases of neurological disease associated with viral infection, such as measles virus (MV)-induced subacute sclerosing panencephalitis in children, it is unclear whether the virus or the antiviral immune response within the brain is the cause of disease. MV inoculation of transgenic mice expressing the human MV receptor, CD46, exclusively in neurons resulted in neuronal infection and fatal encephalitis within 2 weeks in neonates, while mice older than 3 weeks of age were resistant to both infection and disease. At all ages, T lymphocytes infiltrated the brain in response to inoculation. To determine the role of lymphocytes in disease progression, CD46+ mice were back-crossed to T- and B-cell-deficient RAG-2 knockout mice. The lymphocyte deficiency did not affect the outcome of disease in neonates, but adult CD46+RAG-2− mice were much more susceptible to both neuronal infection and central nervous system disease than their immunocompetent littermates. These results indicate that CD46-dependent MV infection of neurons, rather than the antiviral immune response in the brain, produces neurological disease in this model system and that immunocompetent adult mice, but not immunologically compromised or immature mice, are protected from infection.

Gut, bugs, and brain: Role of commensal bacteria in the control of central nervous system disease

2011 ◽  
Vol 69 (2) ◽  
pp. 240-247 ◽  
Author(s):  
Javier Ochoa-Repáraz ◽  
Daniel W. Mielcarz ◽  
Sakhina Begum- Haque ◽  
Lloyd H. Kasper
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Central Nervous System Disease ◽  
Commensal Bacteria ◽  
Nervous System Disease ◽  
System Disease
Sign in / Sign up

Export Citation Format

Share Document