Sulphydryl Donors and Nitrate Therapy

2015 ◽  
pp. 297-311
Author(s):  
John D. Horowitz
Keyword(s):  
Nitrate Therapy

Diabetes and chronic nitrate therapy as co-determinants of somatic DNA damage in patients with coronary artery disease

2005 ◽  
Vol 83 (4) ◽  
pp. 279-286 ◽  
Author(s):  
Maria Grazia Andreassi ◽  
Nicoletta Botto ◽  
Silvana Simi ◽  
Marta Casella ◽  
Samantha Manfredi ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Dna Damage ◽  
Coronary Artery ◽  
Nitrate Therapy ◽  
Artery Disease

Nitrate therapy

2011 ◽  
pp. 263-266
Author(s):  
John Horowitz
Keyword(s):  
Nitrate Therapy

Nitrite-stimulated Gastric Formation of S-nitrosothiols As An Antihypertensive Therapeutic Strategy

2019 ◽  
Vol 20 (4) ◽  
pp. 431-443 ◽  
Author(s):  
Gustavo H. Oliveira-Paula ◽  
Jose E. Tanus-Santos
Keyword(s):  
Related Species ◽  
Reductase Activity ◽  
New Approach ◽  
Lower Blood ◽  
Nitrate Therapy ◽  
Nitrite Reductase Activity ◽  
Acidic Conditions ◽  
No Bioavailability ◽  
Nitrite Nitrate ◽  
Therapy Of Hypertension

Hypertension is usually associated with deficient nitric oxide (NO) bioavailability, and therefore stimulating NO activity is an important antihypertensive strategy. Recently, many studies have shown that both nitrite and nitrate anions are not simple products of NO metabolism and indeed may be reduced back to NO. While enzymes with nitrite-reductase activity capable of generating NO from nitrite may contribute to antihypertensive effects of nitrite, another mechanism involving the generation of NO-related species in the stomach from nitrite has been validated. Under the acidic conditions of the stomach, nitrite generates NO-related species that form S-nitrosothiols. Conversely, drugs that increase gastric pH may impair the gastric formation of S-nitrosothiols, which may mediate antihypertensive effects of oral nitrite or nitrate. Therefore, it is now becoming clear that promoting gastric formation of S-nitrosothiols may result in effective antihypertensive responses, and this mechanism opens a window of opportunity in the therapy of hypertension. In this review, we discuss the recent studies supporting the gastric generation of S-nitrosothiols as a potential antihypertensive mechanism of oral nitrite. We also highlight some drugs that increase S-nitrosothiols bioavailability, which may also improve the responses to nitrite/nitrate therapy. This new approach may result in increased nitrosation of critical pharmacological receptors and enzymes involved in the pathogenesis of hypertension, which tend to respond less to their activators resulting in lower blood pressure.

Methemoglobinemia Associated with Organic Nitrate Therapy

1979 ◽  
Vol 58 (6) ◽  
pp. 521???523 ◽  
Author(s):  
E. E. Fibuch ◽  
W. T Cecil ◽  
W. A. Reed
Keyword(s):  
Organic Nitrate ◽  
Nitrate Therapy
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