Melanoma Immunotherapy with Autologous Tumor Vaccines

1992 ◽  
pp. 312-317
Author(s):  
David Berd
Keyword(s):  
Autologous Tumor ◽  
Tumor Vaccines

scholarly journals Autologous tumor antigens and boron nanosheet-based nanovaccines for enhanced photo-immunotherapy against immune desert tumors

Nanophotonics ◽  
2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Zhe Sun ◽  
Taojian Fan ◽  
Quan Liu ◽  
Luodan Huang ◽  
Weibin Hu ◽  
...  
Keyword(s):  
Immune Cells ◽  
Tumor Antigens ◽  
Photoacoustic Imaging ◽  
Metastatic Potential ◽  
Photothermal Effect ◽  
Patient Specific ◽  
Autologous Tumor ◽  
Tumor Vaccines ◽  
Therapeutic Vaccines ◽  
Important Field

Abstract Personalized therapeutic vaccines against immune desert tumors are an increasingly important field in current cancer immunotherapy. However, limitations in neoantigen recognition, impotent immune cells, and a lack of intratumoral infiltrated lymphocytes pose challenges for the cancer vaccines. Resected tumors contain various of patient-specific tumor autoantigens (TA), and its derived photonanovaccines have unique competency to overcome abovementioned barriers. We constructed a novel personalized photonanovaccine (B@TA-R848) with surgically sourced TA modified on two-dimensional boron nanosheets (BNSs) via polydopamine coating and loaded with immune adjuvant R848. B@TA-R848 has good properties of drug delivery and release, photoacoustic imaging, photothermal effect, and biocompatibility. In a mouse triple-negative breast cancer model, B@TA-R848-based photonanovaccine induced effective systemic antitumor immune responses, altered the local tumor microenvironment, and increased the intratumoral infiltration of immune cells. The combined photo immunotherapy could significantly inhibit tumor growth, recurrence, and metastasis. This work develops a novel photonanovaccine for low immunogenicity and high metastatic potential tumors, which is of great significance for exploring the clinical development of personalized tumor vaccines against immune desert tumors.

scholarly journals The Safety of an Adjuvanted Autologous Cancer Vaccine Platform in Canine Cancer Patients

2018 ◽  
Vol 5 (4) ◽  
pp. 87 ◽  
Author(s):  
Chris Weir ◽  
Annika Oksa ◽  
Jennifer Millar ◽  
Miles Alexander ◽  
Nicola Kynoch ◽  
...  
Keyword(s):  
Adverse Reactions ◽  
Tumor Antigens ◽  
Autologous Tumor ◽  
Tumor Vaccines ◽  
Vaccine Platform ◽  
Safety Study ◽  
Diverse Range ◽  
Canine Cancer ◽  
Ongoing Development ◽  
Vaccine Approach

Canine cancer rates are similar to humans, though the therapeutic options might be limited. Inducing a patient’s own immune system to have an anti-tumor response is an attractive approach to cancer therapy. In this safety study, autologous tumor vaccines produced specifically for each canine patient were combined with Advax™, a novel non-inflammatory immunomodulator and vaccine adjuvant and were tested for safety in a diverse range of patient presentations alone or in combination with other treatments. Canine patients had their tumor biopsied, debulked or resected and the tumor antigens were processed into an autologous vaccine formulated with Advax™ adjuvant with or without rhizavidin as an additional immune stimulant. Patients treated early in the trial received two intramuscular (IM) doses, 2 weeks apart. As the study progressed and no issues of safety were observed, the protocol was changed to weekly vaccinations for 4 weeks followed by monthly booster shots. Over the 150 I.M injections delivered to date, the vaccine was found to be very safe and no significant adverse reactions were observed. These results justify ongoing development and future controlled studies of this autologous vaccine approach.

Various Approaches with Autologous Tumor Vaccines.

2003 ◽  
Vol 96 (Supplement) ◽  
pp. S6
Author(s):  
E. G. Elias ◽  
J. L. Zapas ◽  
S. L. Beam ◽  
S. D. Brown ◽  
B. S. Gentile ◽  
...  
Keyword(s):  
Autologous Tumor ◽  
Tumor Vaccines

Immunological Effects of BCG as an Adjuvant in Autologous Tumor Vaccines

2000 ◽  
Vol 94 (1) ◽  
pp. 64-72 ◽  
Author(s):  
Qiao Li ◽  
Daniel P. Normolle ◽  
Donna M. Sayre ◽  
Xianying Zeng ◽  
Rong Sun ◽  
...  
Keyword(s):  
Autologous Tumor ◽  
Tumor Vaccines ◽  
Immunological Effects
Sign in / Sign up

Export Citation Format

Share Document