Adhesion and Growth Properties of Metastatic Tumor Cells that Colonize Specific Organ Sites

1992 ◽  
pp. 60-94 ◽  
Author(s):  
David G. Menter ◽  
Philip G. Cavanaugh ◽  
Garth L. Nicolson
Keyword(s):  
Tumor Cells ◽  
Metastatic Tumor ◽  
Growth Properties ◽  
Specific Organ

scholarly journals The dynamic behavior of lipid droplets in the pre-metastatic niche

2020 ◽  
Vol 11 (11) ◽  
Author(s):  
Chunliang Shang ◽  
Jie Qiao ◽  
Hongyan Guo
Keyword(s):  
Tumor Cells ◽  
Immune Cells ◽  
Stromal Cells ◽  
Lipid Droplets ◽  
Metastatic Tumor ◽  
Current Evidence ◽  
Biological Functions ◽  
Metastatic Niche ◽  
Niche Formation

AbstractThe pre-metastatic niche is a favorable microenvironment for the colonization of metastatic tumor cells in specific distant organs. Lipid droplets (LDs, also known as lipid bodies or adiposomes) have increasingly been recognized as lipid-rich, functionally dynamic organelles within tumor cells, immune cells, and other stromal cells that are linked to diverse biological functions and human diseases. Moreover, in recent years, several studies have described the indispensable role of LDs in the development of pre-metastatic niches. This review discusses current evidence related to the biogenesis, composition, and functions of LDs related to the following characteristics of the pre-metastatic niche: immunosuppression, inflammation, angiogenesis/vascular permeability, lymphangiogenesis, organotropism, reprogramming. We also address the function of LDs in mediating pre-metastatic niche formation. The potential of LDs as markers and targets for novel antimetastatic therapies will be discussed.

scholarly journals Targeting Intercellular Communication in the Bone Microenvironment to Prevent Disseminated Tumor Cell Escape from Dormancy and Bone Metastatic Tumor Growth

2021 ◽  
Vol 22 (6) ◽  
pp. 2911
Author(s):  
Lauren M. Kreps ◽  
Christina L. Addison
Keyword(s):  
Tumor Cells ◽  
Metastatic Tumor ◽  
Disseminated Tumor Cells ◽  
Tumour Mass ◽  
Cellular Interactions ◽  
Bone Microenvironment ◽  
Cell Functions ◽  
Immunosuppressive Cell ◽  
Metastatic Microenvironment ◽  
Complex Relationships

Metastasis to the bone is a common feature of many cancers including those of the breast, prostate, lung, thyroid and kidney. Once tumors metastasize to the bone, they are essentially incurable. Bone metastasis is a complex process involving not only intravasation of tumor cells from the primary tumor into circulation, but extravasation from circulation into the bone where they meet an environment that is generally suppressive of their growth. The bone microenvironment can inhibit the growth of disseminated tumor cells (DTC) by inducing dormancy of the DTC directly and later on following formation of a micrometastatic tumour mass by inhibiting metastatic processes including angiogenesis, bone remodeling and immunosuppressive cell functions. In this review we will highlight some of the mechanisms mediating DTC dormancy and the complex relationships which occur between tumor cells and bone resident cells in the bone metastatic microenvironment. These inter-cellular interactions may be important targets to consider for development of novel effective therapies for the prevention or treatment of bone metastases.

scholarly journals Bone tumor-targeted delivery of theranostic 195mPt-bisphosphonate complexes promotes killing of metastatic tumor cells

2020 ◽  
pp. 100088
Author(s):  
Robin A. Nadar ◽  
Gerben M. Franssen ◽  
Natasja W.M. Van Dijk ◽  
Karlijn Codee-van der Schilden ◽  
Mirjam de Weijert ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Bone Tumor ◽  
Targeted Delivery ◽  
Metastatic Tumor

Co-operation between metastatic tumor cells and macrophages in the degradation of basement membrane (type IV) collagen

FEBS Letters ◽  
1983 ◽  
Vol 161 (2) ◽  
pp. 243-246 ◽  
Author(s):  
Nicole Henry ◽  
Yves Eeckhout ◽  
Anne-Louise van Lamsweerde ◽  
Gilbert Vaes
Keyword(s):  
Basement Membrane ◽  
Tumor Cells ◽  
Type Iv Collagen ◽  
Metastatic Tumor ◽  
Type Iv ◽  
Membrane Type

scholarly journals Abstract 3751: A mode of treatment resistance of metastatic tumor cells: Propagation exceeds elimination in number

2019 ◽  
Author(s):  
Chie Kudo-Saito ◽  
Yukinori Ozaki ◽  
Keiichi Kinowaki ◽  
Hidetaka Kawabata ◽  
Yamato Ogiwara
Keyword(s):  
Tumor Cells ◽  
Treatment Resistance ◽  
Metastatic Tumor

Histopathological mapping of metastatic tumor cells in sentinel lymph nodes of oral and oropharyngeal squamous cell carcinomas

Head & Neck ◽  
2014 ◽  
Vol 37 (10) ◽  
pp. 1477-1482 ◽  
Author(s):  
Seraina Denoth ◽  
Martina A. Broglie ◽  
Stephan K. Haerle ◽  
Gerhard F. Huber ◽  
Sarah R. Haile ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
Tumor Cells ◽  
Squamous Cell ◽  
Metastatic Tumor ◽  
Sentinel Lymph Nodes ◽  
Squamous Cell Carcinomas
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