Effects of ras Oncogenes on Metastatic Capacity

1992 ◽  
pp. 37-48
Author(s):  
Ann F. Chambers
Keyword(s):  
Metastatic Capacity ◽  
Ras Oncogenes

Alterations of ras oncogenes in UV induced skin tumors

1991 ◽  
Vol 2 (3) ◽  
pp. 198-199
Author(s):  
Chikako Nishigori ◽  
Hiraku Takebe ◽  
Sadao Imamura
Keyword(s):  
Skin Tumors ◽  
Ras Oncogenes

scholarly journals miR-103 Functions as a Tumor Suppressor by Directly Targeting Programmed Cell Death 10 in NSCLC

2018 ◽  
Vol 26 (4) ◽  
pp. 519-528 ◽  
Author(s):  
Dong Yang ◽  
Jian-Jun Wang ◽  
Jin-Song Li ◽  
Qian-Yu Xu
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Cell Death ◽  
Programmed Cell Death ◽  
Tumor Size ◽  
Apoptotic Cell ◽  
A549 Cells ◽  
Invasion And Migration ◽  
Metastatic Capacity ◽  
And Migration

Non-small cell lung cancer (NSCLC) accounts for about 85% of all lung cancer cases. Absence of miR-103 has recently been identified to be associated with metastatic capacity of primary lung tumors. However, the exact role of miR-103 in NSCLC and the molecular mechanism are unclear. In the present study, we showed that miR-103 expression was reduced in NSCLC tissues and cells. miR-103 expression was negatively correlated with tumor size and stage. The overall survival was longer in patients with higher miR-103 level than in those with lower miR-103 expression. miR-103 inhibited cell proliferation in A549 cells, decreased tumor weight and volume, and prolonged survival of tumor-implanted nude mice. miR-103 increased apoptotic cell death in A549 cells. Furthermore, miR-103 decreased the invasion and migration abilities in A549 cells, as evidenced by Transwell and wound healing results. Downregulation of miR-103 significantly reduced the level of programmed cell death 10 (PDCD10). We found a significant decrease in the relative luciferase activity of the reporter gene in A549 cells cotransfected with the miR-103 mimic and pGL3-PDCD10 WT 3′-UTR, but not pGL3-PDCD10 mut 3′-UTR. We showed that overexpression of PDCD10 significantly inhibited miR-103-induced inhibition of cell proliferation, increased apoptosis, and decreased invasion and migration in A549 cells. Moreover, we found that PDCD10 expression was increased in NSCLC tissues and cells. PDCD10 expression was positively correlated with tumor size and stage. Overexpression of PDCD10 increased cell proliferation and inhibited apoptosis in A549 cells. The data demonstrated that dysregulation of the miR-103/PDCD10 signal may be a novel therapeutic target for the treatment of NSCLC.

Early Detection of ras Oncogenes Activated by Chemical Carcinogentreatment

ras Oncogenes ◽  
1989 ◽  
pp. 19-22
Author(s):  
R. Kumar ◽  
S. Sukumar ◽  
M. Barbacid
Keyword(s):  
Early Detection ◽  
Ras Oncogenes

scholarly journals An in vitro correlation of metastatic capacity and dual mechanostimulation

PLoS ONE ◽  
2018 ◽  
Vol 13 (11) ◽  
pp. e0207490
Author(s):  
Indrajyoti Indra ◽  
Alexander N. Gasparski ◽  
Karen A. Beningo
Keyword(s):  
Metastatic Capacity

scholarly journals Epigenetic regulation of CD271, a potential cancer stem cell marker associated with chemoresistance and metastatic capacity

2014 ◽  
Vol 33 (1) ◽  
pp. 425-432 ◽  
Author(s):  
SULAN LI ◽  
DONGLI YUE ◽  
XINFENG CHEN ◽  
LIPING WANG ◽  
JIEYAO LI ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cancer Stem Cell ◽  
Epigenetic Regulation ◽  
Stem Cell Marker ◽  
Cancer Stem Cell Marker ◽  
Cell Marker ◽  
Metastatic Capacity ◽  
Potential Cancer

scholarly journals Hepatoma SK Hep-1 Cells Exhibit Characteristics of Oncogenic Mesenchymal Stem Cells with Highly Metastatic Capacity

PLoS ONE ◽  
2014 ◽  
Vol 9 (10) ◽  
pp. e110744 ◽  
Author(s):  
Jong Ryeol Eun ◽  
Yong Jin Jung ◽  
Yanling Zhang ◽  
Yanhong Zhang ◽  
Benjamin Tschudy-Seney ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Metastatic Capacity

c-K-ras Oncogenes: Prevalence in Livers of Winter Flounder from Boston Harbor

2018 ◽  
pp. 229-236
Author(s):  
L. Gerald McMahon ◽  
Julie Huber ◽  
Michael J. Moore ◽  
John J. Stegeman ◽  
Gerald N. Wogan
Keyword(s):  
Winter Flounder ◽  
Boston Harbor ◽  
Ras Oncogenes
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