Evaluation of Esophageal Sensitivity

2015 ◽  
pp. 344-365 ◽  
Author(s):  
Stanislas Bruley des Varannes ◽  
Jean-Paul Galmiche
Keyword(s):  
Esophageal Sensitivity

Esophageal Sensitivity to Mecholyl in Cardiospasm

1951 ◽  
Vol 19 (2) ◽  
pp. 242-253 ◽  
Author(s):  
Philip Kramer ◽  
Franz J. Ingeleinger
Keyword(s):  
Esophageal Sensitivity

Esophageal sensitivity and symptom perception in gastroesophageal reflux disease

1999 ◽  
Vol 1 (3) ◽  
pp. 214-219 ◽  
Author(s):  
Guoxiang Shi ◽  
Roger P. Tatum ◽  
Raymond J. Joehl ◽  
Peter J. Kahrilas
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Gastroesophageal Reflux ◽  
Reflux Disease ◽  
Symptom Perception ◽  
Esophageal Sensitivity

scholarly journals Tu1867 Detection of Pepsin in Saliva As a Biomarker of Esophageal Sensitivity to Reflux

2014 ◽  
Vol 146 (5) ◽  
pp. S-859
Author(s):  
Jamal O. Hayat ◽  
Shirley Gabieta ◽  
Andrew Woodcock ◽  
Peter W. Dettmar ◽  
Jerry Mabary ◽  
...  
Keyword(s):  
Esophageal Sensitivity

The role of serotonin in the control of esophageal sensitivity assessed by multimodal stimulation in health

2020 ◽  
Author(s):  
Charlotte Broers ◽  
Annelies Geeraerts ◽  
Veerle Boecxstaens ◽  
Brecht Van Houtte ◽  
Hannelore Geysen ◽  
...  
Keyword(s):  
Esophageal Sensitivity

scholarly journals The effect of intravenous corticotropin-releasing hormone administration on esophageal sensitivity and motility in health

2017 ◽  
Vol 312 (5) ◽  
pp. G526-G534 ◽  
Author(s):  
Charlotte Broers ◽  
Chloé Melchior ◽  
Lukas Van Oudenhove ◽  
Tim Vanuytsel ◽  
Brecht Van Houtte ◽  
...  
Keyword(s):  
Esophageal Motility ◽  
The Other ◽  
Flow Index ◽  
Corticotropin Releasing Hormone ◽  
Pressure Flow ◽  
Releasing Hormone ◽  
Impedance Ratio ◽  
Esophageal Sensitivity ◽  
Esophageal Contractility ◽  
Increased Pressure

Esophageal hypersensitivity is important in gastroesophageal reflux disease (GERD) patients who are refractory to acid-suppressive therapy. Stress affects visceral sensitivity and exacerbates heartburn in GERD. Peripheral CRH is a key mediator of the gut stress response. We hypothesize that CRH increases esophageal sensitivity and alters esophageal motility in health. Esophageal sensitivity to thermal, mechanical, electrical, and chemical stimuli was assessed in 14 healthy subjects after administration of placebo or CRH (100 μg iv). Perception scores were assessed for first perception, pain perception threshold (PPT), and pain tolerance threshold (PTT). Esophageal motility was investigated by high-resolution impedance manometry, before and after CRH and evaluated by distal contractile integral (DCI) and intrabolus pressure (IBP). Pressure flow analysis assessed bolus clearance (impedance ratio), degree of pressurization needed to propel bolus onward (IBP slope), and pressure flow (pressure flow index, PFI). Stress and mood were assessed during the study. Sensitivity to mechanical distention was increased after CRH compared with placebo (PPT: P = 0.0023; PTT: P = 0.0253). CRH had no influence on the other stimulations. DCI was increased for all boluses (liquid, P = 0.0012; semisolid, P = 0.0017; solid, P = 0.0107). Impedance ratio for liquid ( P < 0.0001) and semisolid swallows ( P = 0.0327) decreased after CRH. IBP slope increased after CRH for semisolid ( P = 0.0041) and solid ( P = 0.0003) swallows. PFI increased for semisolid ( P = 0.0017) and solid swallows ( P = 0.0031). CRH increased esophageal sensitivity to mechanical distention, not to the other stimulation modalities. CRH increased esophageal contractility and tone, decreased LES relaxation, increased esophageal bolus pressurization, improved esophageal bolus clearance, and increased pressure flow.NEW & NOTEWORTHY This is the first study to address the effect of corticotropin-releasing hormone (CRH) on esophageal sensitivity and alterations in motility in health. CRH administration increased esophageal sensitivity to mechanical distention. This effect is accompanied by an increase in esophageal contractility and tone and a decrease in lower esophageal sphincter relaxation. CRH increased esophageal bolus pressurization, improved esophageal bolus clearance, and increased pressure flow. The changes in esophageal contractile properties may underlie the increased sensitivity to mechanical distention after CRH.

Radiofrequency delivery at the gastroesophageal junction in GERD improves acid exposure and symptoms and decreases esophageal sensitivity to acid infusion

2003 ◽  
Vol 124 (4) ◽  
pp. A19 ◽  
Author(s):  
Joris Arts ◽  
August Van Olmen ◽  
Geert D'Haens ◽  
Daniel Sifrim ◽  
Antoon Lerut ◽  
...  
Keyword(s):  
Gastroesophageal Junction ◽  
Acid Exposure ◽  
Acid Infusion ◽  
Esophageal Sensitivity

Mo1863 Modality Specific Alterations of Esophageal Sensitivity Caused by Longstanding Diabetes Mellitus

2012 ◽  
Vol 142 (5) ◽  
pp. S-703
Author(s):  
Jan Brun ◽  
Christina Brock ◽  
Jens B. Frokjaer ◽  
Eirik Søfteland ◽  
Magnus Simren ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Esophageal Sensitivity
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