Emerging Techniques of Investigation in the Study of Renal Biopsies from Patients with Systemic Lupus erythematosus

2015 ◽  
pp. 66-71 ◽  
Author(s):  
S. Feriozzi ◽  
A. Onetti Muda ◽  
A. Stoppacciaro ◽  
F. Stella ◽  
T. Faraggiana
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Renal Biopsies

scholarly journals Clinical And Morphological Improvement Of Lupus Nephritis Treated With Rituximab

Folia Medica ◽  
2014 ◽  
Vol 56 (4) ◽  
pp. 245-252 ◽  
Author(s):  
Maria E. Tsanyan ◽  
Sergey K. Soloviev ◽  
Stefka G. Radenska-Lopovok ◽  
Anna V. Torgashina ◽  
Ekaterina V. Nikolaeva ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Nephritis ◽  
Cell Therapy ◽  
Disease Activity ◽  
B Cell ◽  
Renal Biopsy ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Renal Biopsies

Abstract Aim: TO assess the effects of rituximab (RTM) therapy on clinical and morphologic activity of lupus nephritis (LN). Material and methods: The study included 45 patients with confirmed diagnosis of systemic lupus erythematosus (SLE), unaffected by previously received standard therapy with glucocorticoids (GCs) and cytostatics. The disease activity was assessed using Systemic Lupus Erythematosus Disease Activity Index 2000 (SLEDAI 2K); to assess the LN activity we used the SLICC RA/RE index. Forty-five patients with LN were given puncture renal biopsy prior to prescribing RTM; 16 patients had repeated renal biopsy 1 year and more after beginning the anti-B-cell therapy. LN was graded histologically in accordance with the WHO classification (2003) with indices of activity (AI) and chronicity (CI). Results: The predominant number of patients had class III - IV of LN. The repeated renal biopsies demonstrated that LN had undergone a transition into a more favourable morphologic class, which was associated, in most of these cases, with a positive therapeutic effect. The follow-up dynamics showed a statistically significant reduction of AI (p=0.006), and no statistically significant changes in the CI (p = 0.14). Conclusion: The long-term follow-up in the study has showed that repeated courses of anti-B-cell therapy with RTM have a positive effect both on SLE activity and generally on the renal process. The reduction of the morphologic class of LN as assessed in the repeated renal biopsies is a convincing proof for this. Eleven out of 16 patients experienced transition of the morphologic class into a more favourable type, which in most cases was combined with lower AI (p = 0.006). We found no evidence of increase in the CI (p = 0.14).

scholarly journals Glomerular cytoplasmic tubular structures in renal biopsies of patients with systemic lupus erythematosus and other diseases

1971 ◽  
Vol 14 (4) ◽  
pp. 539-550 ◽  
Author(s):  
Eric R. Hurd ◽  
Edwin Eigenbrodt ◽  
Howard Worthen ◽  
Stanley S. Strunk ◽  
Morris Ziff
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Tubular Structures ◽  
Systemic Lupus ◽  
Renal Biopsies

THU0162 Thrombotic microangiopathy in renal biopsies from patients with systemic lupus erythematosus

2013 ◽  
Vol 71 (Suppl 3) ◽  
pp. 210.2-210
Author(s):  
J. Gerhardsson ◽  
A. Zickert ◽  
B. Sundelin ◽  
E. Svenungsson ◽  
I. Gunnarsson
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Thrombotic Microangiopathy ◽  
Systemic Lupus ◽  
Renal Biopsies

Negative Anti-C1q Antibody Titers May Influence Therapeutic Decisions and Reduce the Number of Renal Biopsies in Systemic Lupus Erythematosus

2011 ◽  
Vol 118 (4) ◽  
pp. c355-c360 ◽  
Author(s):  
Carlos Geraldo Guerreiro de Moura ◽  
Cristóvão Luis Pitangueira Mangueira ◽  
Luzia Arlinda Sampaio Cruz ◽  
Constança Margarida Sampaio Cruz
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Systemic Lupus ◽  
Therapeutic Decisions ◽  
Renal Biopsies ◽  
Antibody Titers

scholarly journals Histopathological and Direct Immunofluorescent Changes in Renal Biopsies of Patients with Systemic Lupus Erythematosus

JMS SKIMS ◽  
2012 ◽  
Vol 15 (2) ◽  
pp. 162-165
Author(s):  
Rohi Wani ◽  
Azra Shah ◽  
M Saleem Najar ◽  
Parveen Shah
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Who Classification ◽  
Renal Involvement ◽  
Histopathological Changes ◽  
Systemic Lupus ◽  
Histological Features ◽  
Renal Biopsies ◽  
Class Iv ◽  
Morphological Patterns

BACKGROUND: Renal involvement in Systemic lupus erythematosus (SLE) can display diverse morphological patterns. OBJECTIVES: To study the histopathological changes along with activity and chronicity of lesions in kidney biopsies of patients with SLE. METHODS: Thirty-five renal biopsies of SLE patients were received during two and a half years period. The biopsies were classified according to the WHO classification. Immunofluorescence pattern was also studied and correlated with histological features. RESULTS: There were 32(91.4%) females and 3(8.6%) males. Age of the subjects ranged from 15 to 60 years with a mean age of 33.48 years. The most common class of lupus nephritis was class IV which was observed in 54.29% of biopsies. Immunofluorescence was performed in 30 biopsies and all these were positive for various antisera with anti-IgG positivity in 27(90%). Mesangial deposits were seen in 13(43.3%) cases followed by granular deposits in 9(30%) cases. CONCLUSION: Majority of SLE cases at SKIMS present during the severe course of the disease. JMS 2012;15(2):162-65

Organized Intraglomerular Deposits in NZB Mouse Disease

1971 ◽  
Vol 29 ◽  
pp. 544-545
Author(s):  
Francis R. Comerford ◽  
Alan S. Cohen
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Antinuclear Antibodies ◽  
Human Systemic Lupus Erythematosus ◽  
Systemic Lupus ◽  
Glomerular Lesion ◽  
Ultrastructural Studies ◽  
Dense Deposits ◽  
Experimental Nephritis ◽  
Glomerular Lesions

Mice of the inbred NZB strain develop a spontaneous disease characterized by autoimmune hemolytic anemia, positive lupus erythematosus cell tests and antinuclear antibodies and nephritis. This disease is analogous to human systemic lupus erythematosus. In ultrastructural studies of the glomerular lesion in NZB mice, intraglomerular dense deposits in mesangial, subepithelial and subendothelial locations were described. In common with the findings in many examples of human and experimental nephritis, including many cases of human lupus nephritis, these deposits were amorphous or slightly granular in appearance with no definable substructure.We have recently observed structured deposits in the glomeruli of NZB mice. They were uncommon and were found in older animals with severe glomerular lesions by morphologic criteria. They were seen most commonly as extracellular elements in subendothelial and mesangial regions. The deposits ranged up to 3 microns in greatest dimension and were often adjacent to deposits of lipid-like round particles of 30 to 250 millimicrons in diameter and with amorphous dense deposits.

“Subcortical” cognitive impairment in patients with systemic lupus erythematosus

2000 ◽  
Vol 6 (7) ◽  
pp. 821-825 ◽  
Author(s):  
ELIZABETH LERITZ ◽  
JASON BRANDT ◽  
MELISSA MINOR ◽  
FRANCES REIS-JENSEN ◽  
MICHELLE PETRI
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Cognitive Impairment ◽  
Lupus Erythematosus ◽  
Systemic Lupus
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