Treatment of Diffuse Proliferative Lupus Nephritis

2015 ◽  
pp. 55-59
Author(s):  
C. Ponticelli ◽  
G. Moroni ◽  
G. Banfi
Keyword(s):  
Lupus Nephritis ◽  
Proliferative Lupus Nephritis

Good outcomes with mycophenolate-cyclosporine-based induction protocol in children with severe proliferative lupus nephritis

Lupus ◽  
2010 ◽  
Vol 19 (8) ◽  
pp. 965-973 ◽  
Author(s):  
E. Aragon ◽  
YH Chan ◽  
KH Ng ◽  
YW Lau ◽  
PH Tan ◽  
...  
Keyword(s):  
Lupus Nephritis ◽  
Proliferative Lupus Nephritis

scholarly journals Long-term follow-up of the MAINTAIN Nephritis Trial, comparing azathioprine and mycophenolate mofetil as maintenance therapy of lupus nephritis

2015 ◽  
Vol 75 (3) ◽  
pp. 526-531 ◽  
Author(s):  
Farah Tamirou ◽  
David D'Cruz ◽  
Shirish Sangle ◽  
Philippe Remy ◽  
Carlos Vasconcelos ◽  
...  
Keyword(s):  
Mycophenolate Mofetil ◽  
Lupus Nephritis ◽  
Positive Predictive Value ◽  
Maintenance Therapy ◽  
Early Response ◽  
Renal Outcome ◽  
Proliferative Lupus Nephritis ◽  
Long Term Follow Up

ObjectiveTo report the 10-year follow-up of the MAINTAIN Nephritis Trial comparing azathioprine (AZA) and mycophenolate mofetil (MMF) as maintenance therapy of proliferative lupus nephritis, and to test different definitions of early response as predictors of long-term renal outcome.MethodsIn 2014, data on survival, kidney function, 24 h proteinuria, renal flares and other outcomes were collected for the 105 patients randomised between 2002 and 2006, except in 13 lost to follow-up.ResultsDeath (2 and 3 in the AZA and MMF groups, respectively) and end-stage renal disease (1 and 3, respectively) were rare events. Time to renal flare (22 and 19 flares in AZA and MMF groups, respectively) did not differ between AZA and MMF patients. Patients with good long-term renal outcome had a much more stringent early decrease of 24 h proteinuria compared with patients with poor outcome. The positive predictive value of a 24 h proteinuria <0.5 g/day at 3 months, 6 months and 12 months for a good long-term renal outcome was excellent (between 89% and 92%). Inclusion of renal function and urinalysis in the early response criteria did not impact the value of early proteinuria decrease as long-term prognostic marker.ConclusionsThe long-term follow-up data of the MAINTAIN Nephritis Trial do not indicate that MMF is superior to AZA as maintenance therapy in a Caucasian population suffering from proliferative lupus nephritis. Moreover, we confirm the excellent positive predictive value of an early proteinuria decrease for long-term renal outcome.Trial registration numberNCT00204022.

EFFECT OF MYCOPHENOLATE MOFETIL THERAPY COMBINED WITH PREDNISONE FOR THE TREATMENT OF PROLIFERATIVE LUPUS NEPHRITIS

2006 ◽  
Vol 12 (Supplement) ◽  
pp. S64
Author(s):  
H Esteva-Spinetti ◽  
Mar??a Camargo-Duque ◽  
Eylen M. Serrano Casas ◽  
C Juan ◽  
Sandra Romero-Aguaida
Keyword(s):  
Mycophenolate Mofetil ◽  
Lupus Nephritis ◽  
Proliferative Lupus Nephritis
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