T-Cell-Dependent Shock Induced by a Bacterial Superantigen

2015 ◽  
pp. 172-184 ◽  
Author(s):  
Thomas Miethke ◽  
Helmut Gaus ◽  
Claudia Wahl ◽  
Klaus Heeg ◽  
Hermann Wagner
Keyword(s):  
T Cell ◽  
Bacterial Superantigen

scholarly journals Structural basis of T-cell specificity and activation by the bacterial superantigen TSST-1

2007 ◽  
Vol 26 (4) ◽  
pp. 1187-1197 ◽  
Author(s):  
Beenu Moza ◽  
Ashok K Varma ◽  
Rebecca A Buonpane ◽  
Penny Zhu ◽  
Christine A Herfst ◽  
...  
Keyword(s):  
T Cell ◽  
Structural Basis ◽  
Cell Specificity ◽  
Bacterial Superantigen

Clonal deletion as direct consequence of anin vivo T cell response to bacterial superantigen

1993 ◽  
Vol 23 (5) ◽  
pp. 1197-1200 ◽  
Author(s):  
Claudia Wahl ◽  
Thomas Miethke ◽  
Klaus Heeg ◽  
Hermann Wagner
Keyword(s):  
T Cell ◽  
Cell Response ◽  
Direct Consequence ◽  
T Cell Response ◽  
Clonal Deletion ◽  
Bacterial Superantigen

scholarly journals Cloning, expression and interaction of human T-cell receptors with the bacterial superantigen SSA

2004 ◽  
Vol 271 (20) ◽  
pp. 4075-4083 ◽  
Author(s):  
Mauricio C. De Marzi ◽  
Marisa M. Fernández ◽  
Eric J. Sundberg ◽  
Luciana Molinero ◽  
Norberto W. Zwirner ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Receptors ◽  
Cell Receptors ◽  
Human T Cell ◽  
Bacterial Superantigen

scholarly journals Evidence for a functional interaction between the beta chain of major histocompatibility complex class II and the T cell receptor alpha chain during recognition of a bacterial superantigen.

1994 ◽  
Vol 180 (5) ◽  
pp. 1931-1935 ◽  
Author(s):  
A M Deckhut ◽  
Y Chien ◽  
M A Blackman ◽  
D L Woodland
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Cell Recognition ◽  
Beta Chain ◽  
Functional Interaction ◽  
T Cell Recognition ◽  
Alpha Chain ◽  
Histocompatibility Complex ◽  
Bacterial Superantigen

Several studies have suggested that there is a direct interaction between the T cell receptor (TCR) and the major histocompatibility complex (MHC) molecule during T cell recognition of superantigen. To further investigate this possibility, we have analyzed T cell recognition of a bacterial superantigen, Staphylococcal enterotoxin B (SEB), presented by a series of mutant murine I-Ek molecules in which residues of either the alpha or beta chain predicted to interact with the TCR have been substituted. Individual T cell hybridomas gave distinct patterns of responsiveness to SEB presented by the I-E beta k mutants that could not be attributed to differences in the binding of SEB to the mutants. This effect appeared to be dependent on the TCR-alpha chain because some of these hybridomas expressed identical TCR transgenic beta chains. In contrast, none of the hybridomas gave distinct patterns of responsiveness to SEB presented by the I-E alpha k mutants. Taken together, these observations support the idea that there is a functional interaction between the alpha chain of the TCR and the beta chain of the MHC class II molecule. The data also support the idea that this interaction might enhance superantigen recognition in some cases.

scholarly journals Proliferation is a prerequisite for bacterial superantigen-induced T cell apoptosis in vivo.

1995 ◽  
Vol 181 (6) ◽  
pp. 2283-2287 ◽  
Author(s):  
T Renno ◽  
M Hahne ◽  
H R MacDonald
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Receptor ◽  
Clonal Deletion ◽  
T Cell Apoptosis ◽  
Adult Mice ◽  
Proliferation And Apoptosis ◽  
Differential Responsiveness ◽  
Bacterial Superantigen

Staphylococcal enterotoxin B (SEB) is a bacterial superantigen that binds to major histocompatibility complex class II molecules and selectively interacts with T cells that bear certain T cell receptor (TCR) V beta domains. Administration of SEB in adult mice results in initial proliferation of V beta 8+ T cells followed by a state of unresponsiveness resulting from a combination of clonal deletion and clonal anergy in the SEB-reactive population. At this time, it is unclear what relationship exists between the T cells that have proliferated and those that have been deleted or have become anergic. Here we show that only a fraction of the potentially reactive V beta 8+ T cells proliferate in response to SEB in vivo, and that all the cells that have proliferated eventually undergo apoptosis. Virtually no apoptosis can be detected in the nonproliferating V beta 8+ T cells. These data demonstrate a causal relationship between proliferation and apoptosis in response to SEB in vivo, and they further indicate that T cells bearing the same TCR V beta segment can respond differently to the same superantigen. The implications of this differential responsiveness in terms of activation and tolerance are discussed.

Bacterial superantigen specificities of mouse T cell receptor Vβ20

1995 ◽  
Vol 25 (12) ◽  
pp. 3425-3430 ◽  
Author(s):  
Yolanda Bravo de Alba ◽  
Pierre-André Cazenave ◽  
Patrice N. Marche
Keyword(s):  
T Cell ◽  
T Cell Receptor ◽  
Cell Receptor ◽  
Bacterial Superantigen

An MHC class II-expressing T cell clone presenting conventional antigen lacks the ability to present bacterial superantigen

1995 ◽  
Vol 7 (7) ◽  
pp. 1079-1085 ◽  
Author(s):  
Deming Sun ◽  
David L. Woodland ◽  
Christopher Coleclough ◽  
Uwe Wendling ◽  
Konrad Reske
Keyword(s):  
T Cell ◽  
Mhc Class Ii ◽  
Cell Clone ◽  
Class Ii ◽  
T Cell Clone ◽  
Bacterial Superantigen

T cell anergy is programmed early after exposure to bacterial superantigen in vivo

1993 ◽  
Vol 5 (11) ◽  
pp. 1375-1382 ◽  
Author(s):  
Kouichi Yuh ◽  
Katherine A. Siminovitch ◽  
Atsuo Ochi
Keyword(s):  
T Cell ◽  
T Cell Anergy ◽  
Cell Anergy ◽  
Bacterial Superantigen
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