Induction, Regulation and Function of T-Cell Subsets in Leishmaniasis

2015 ◽  
pp. 117-135 ◽  
Author(s):  
F. Y. Liew
Keyword(s):  
T Cell ◽  
T Cell Subsets ◽  
And Function

T Cell Subsets and Function

1986 ◽  
pp. 941-948 ◽  
Author(s):  
P.C.L. Beverley ◽  
L. Terry ◽  
A. Pickford
Keyword(s):  
T Cell ◽  
T Cell Subsets ◽  
And Function

Cytokines in the generation and function of regulatory T cell subsets in leishmaniasis

Cytokine ◽  
2020 ◽  
pp. 155266 ◽  
Author(s):  
Sanhita Ghosh ◽  
Kamalika Roy ◽  
Radhakrishnan Rajalingam ◽  
Sunil Martin ◽  
Chiranjib Pal
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
T Cell Subsets ◽  
And Function

scholarly journals Increased Activation and Oligoclonality of Peripheral CD8+ T Cells in the Chronic Human Helminth Infection Alveolar Echinococcosis

2002 ◽  
Vol 70 (3) ◽  
pp. 1168-1174 ◽  
Author(s):  
Burkhard J. Manfras ◽  
Stefan Reuter ◽  
Thomas Wendland ◽  
Peter Kern
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Alveolar Echinococcosis ◽  
Ex Vivo ◽  
Active Role ◽  
Cell Receptor ◽  
T Cell Subsets ◽  
And Function

ABSTRACT Alveolar echinococcosis (AE) in humans is a chronic disease characterized by slowly expanding liver lesions. Cellular immunity restricts the spreading of the extracellular pathogen, but functional contributions of CD4+ and CD8+ T cells are not defined. Here we studied ex vivo the phenotype and function of circulating T-cell subsets in AE patients by means of flow cytometry, T-cell receptor spectratyping, and lymphocyte proliferation. AE patients with parasitic lesions displayed a significant increase of activation of predominantly CD8+ T cells compared to healthy controls and AE patients without lesions. In vitro, proliferative T-cell responses to polyclonal stimulation with recall antigens and Echinococcus multilocularis vesicular fluid antigen were sustained during chronic persisting infection in all AE patients. Only in AE patients with parasitic lesions did T-cell receptor spectratyping reveal increased oligoclonality of CD8+ but not CD4+ T cells, suggesting a persistent antigenic drive for CD8+ T cells with subsequent proliferation of selected clonotypes. Thus, our data provide strong evidence for an active role of CD8+ T cells in AE.

Role of Ets Proteins in Development, Differentiation, and Function of T-Cell Subsets

2015 ◽  
Vol 36 (2) ◽  
pp. 193-220 ◽  
Author(s):  
Mian Liu ◽  
Weiwu Gao ◽  
Jennifer C. van Velkinburgh ◽  
Yuzhang Wu ◽  
Bing Ni ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Subsets ◽  
Ets Proteins ◽  
And Function

scholarly journals Phenotypical and Functional Analysis of Intraepithelial Lymphocytes from Small Intestine of Mice in Oral Tolerance

2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
Maristela Ruberti ◽  
Luis Gustavo Romani Fernandes ◽  
Patricia Ucelli Simioni ◽  
Dirce Lima Gabriel ◽  
Áureo Tatsumi Yamada ◽  
...  
Keyword(s):  
Small Intestine ◽  
T Cell ◽  
Oral Tolerance ◽  
Cell Subset ◽  
Intraepithelial Lymphocytes ◽  
T Cell Subsets ◽  
T Cell Subset ◽  
Small Intestines ◽  
And Function ◽  
Lower Expression

In this work, we evaluated the effects of administration of OVA on phenotype and function of intraepithelial lymphocytes (IELs) from small intestine of transgenic (TGN) DO11.10 and wild-type BALB/c mice. While the small intestines from BALB/c presented a well preserved structure, those from TGN showed an inflamed aspect. The ingestion of OVA induced a reduction in the number of IELs in small intestines of TGN, but it did not change the frequencies of CD8+and CD4+T-cell subsets. Administration of OVA via oral + ip increased the frequency of CD103+cells in CD4+T-cell subset in IELs of both BALB/c and TGN mice and elevated its expression in CD8β+T-cell subset in IELs of TGN. The frequency of Foxp3+cells increased in all subsets in IELs of BALB/c treated with OVA; in IELs of TGN, it increased only in CD25+subset. IELs from BALB/c tolerant mice had lower expression of all cytokines studied, whereas those from TGN showed high expression of inflammatory cytokines, especially of IFN-γ, TGF-β, and TNF-α. Overall, our results suggest that the inability of TGN to become tolerant may be related to disorganization and altered proportions of inflammatory/regulatory T cells in its intestinal mucosa.

scholarly journals γδ T cell subsets: A link between TCR and function?

2010 ◽  
Vol 22 (4) ◽  
pp. 193-198 ◽  
Author(s):  
Rebecca L. O’Brien ◽  
Willi K. Born
Keyword(s):  
T Cell ◽  
T Cell Subsets ◽  
Γδ T Cell ◽  
And Function

Evaluation of the expression and function of the P2X7 receptor and ART1 in human regulatory T-cell subsets

Immunobiology ◽  
2016 ◽  
Vol 221 (1) ◽  
pp. 84-93 ◽  
Author(s):  
Juan D. Cortés-Garcia ◽  
Cintya López-López ◽  
Nancy Cortez-Espinosa ◽  
Mariana H. García-Hernández ◽  
Juan M. Guzmán-Flores ◽  
...  
Keyword(s):  
T Cell ◽  
Regulatory T Cell ◽  
P2x7 Receptor ◽  
T Cell Subsets ◽  
And Function

scholarly journals Spontaneous and glucocorticoid-induced apoptosis in human mature T lymphocytes

Blood ◽  
1995 ◽  
Vol 86 (11) ◽  
pp. 4199-4205 ◽  
Author(s):  
M Brunetti ◽  
N Martelli ◽  
A Colasante ◽  
M Piantelli ◽  
P Musiani ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Interleukin 2 ◽  
Cell Number ◽  
T Cell Subsets ◽  
Dependent Manner ◽  
Cell Repertoire ◽  
Induced Apoptosis ◽  
And Function ◽  
Dose Dependent

Glucocorticoid (GC)-induced apoptosis is a well-recognized physiologic regulator of murine T-cell number and function. We have analyzed its mechanisms in human mature T cells, which have been thought to be insensitive until recently. Peripheral blood T cells showed sensitivity to GC-induced apoptosis soon after the proliferative response to a mitogenic stimulation, and were also sensitive to spontaneous (ie, growth factor deprivation-dependent) apoptosis. CD8+ T cells were more sensitive to both forms than CD4+ T cells. Acquisition of sensitivity to GC-induced apoptosis was not associated with any change in number or affinity of GC receptors. Both spontaneous and GC-induced apoptosis were increased by the macromolecular synthesis inhibitors, cycloheximide (CHX) and puromycin. A positive correlation between the degree of protein synthesis inhibition and the extent of apoptosis was observed. Interleukin-2 (IL-2) IL-4, and IL-10 protected (IL-2 > IL-10 > IL-4) T cells from both forms of apoptosis in a dose-dependent manner. Our data suggest that spontaneous and GC-induced apoptosis regulate the human mature T-cell repertoire by acting early after the immune response and differentially affecting T-cell subsets.

scholarly journals Immune Suppressive Effects of Tonsil-Derived Mesenchymal Stem Cells on Mouse Bone-Marrow-Derived Dendritic Cells

2015 ◽  
Vol 2015 ◽  
pp. 1-12 ◽  
Author(s):  
Minhwa Park ◽  
Yu-Hee Kim ◽  
Jung-Hwa Ryu ◽  
So-Youn Woo ◽  
Kyung-Ha Ryu
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
Cell Therapy ◽  
T Cell Subsets ◽  
Regulatory Function ◽  
Mouse Bone Marrow ◽  
And Function

Mesenchymal stem cells (MSCs) are considered valuable sources for cell therapy because of their immune regulatory function. Here, we investigated the effects of tonsil-derived MSCs (T-MSCs) on the differentiation, maturation, and function of dendritic cells (DCs). We examined the effect of T-MSCs on differentiation and maturation of bone-marrow- (BM-) derived monocytes into DCs and we found suppressive effect of T-MSCs on DCs via direct contact as well as soluble mediators. Moreover, T cell proliferation, normally increased in the presence of DCs, was inhibited by T-MSCs. Differentiation of CD4+T cell subsets by the DC-T cell interaction also was inhibited by T-MSCs. The soluble mediators suppressed by T-MSCs were granulocyte-macrophage colony-stimulating factor (GM-CSF), RANTES, interleukin-6 (IL-6), and monocyte chemoattractant protein-1 (MCP-1). Taken together, T-MSCs exert immune modulatory function via suppression of the differentiation, maturation, and function of BM-derived DCs. Our data suggests that T-MSCs could be used as a novel source of stem cell therapy as immune modulators.

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