Perspectives in Acid-Base Balance in Advanced Chronic Renal Failure

2015 ◽  
pp. 105-117 ◽  
Author(s):  
G. M. Berlyne ◽  
A. J. Adler ◽  
R. H. Barth ◽  
D. Burke ◽  
C. E. Palant
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance

The effect of atrial natriuretic peptide on acid-base balance in rats with chronic renal failure

Life Sciences ◽  
1988 ◽  
Vol 42 (25) ◽  
pp. 2577-2585
Author(s):  
Miho Kusaka ◽  
Keiichiro Atarashi ◽  
Atsushi Numabe ◽  
Yuzaburo Baba ◽  
Kaori Shinozaki ◽  
...  
Keyword(s):  
Renal Failure ◽  
Chronic Renal Failure ◽  
Atrial Natriuretic Peptide ◽  
Natriuretic Peptide ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance ◽  
Atrial Natriuretic

scholarly journals The analysis of acid-base balance in haemodialyzed patients and the effect of etiology of chronic renal failure on acid-base parameter values

2004 ◽  
Vol 23 (2) ◽  
pp. 175-178
Author(s):  
Emina Colak ◽  
Sanja Stankovic ◽  
Nada Majkic-Singh ◽  
Milan Radovic
Keyword(s):  
Renal Failure ◽  
Metabolic Acidosis ◽  
Chronic Renal Failure ◽  
Underlying Disease ◽  
Tubular Secretion ◽  
Acid Base Balance ◽  
Acid Base ◽  
Significant Difference ◽  
Before And After ◽  
Base Balance

Due to reduced scope of renal function in chronic renal failure (CRF) it is not rare that it comes to marked metabolic acidosis and pathologic catabolism associated with hypoxia. The cause of metabolic acidosis is deminished tubular secretion of ammonia, due to reduced synthesis, stipulated by lower number of renal canaliculi. Acid-base balance was analyzed in 74 patients suffering from CRF who were on haemodialysis program. Heparinised blood was taken from these patients before and after haemodialysis in which the following parameters were measured: pH, pCO2, pO2, HCO-3 ?, TCO2. The aim of this study was the monitoring of patients' acid-base status before and after haemodilalysis in order to evaluate the degree of stabilization of acid-base balance after haemodilalysis and also to define the correlation between the etiology of CRF and the degree of acid-base balance disorder. In relation to underlying disease resulting in CRF, the patients were divided into five groups: I-tubular interstitial nephrosis (TIN), II-polycystic kidney disease (ADPKD), III-glomerulonephritis (GN), IVhypertension and nephroangio-sclerosis (HTA-Nascl) and V-consisting of patients whose underlying disease was not diagnosed (ERSD). The obtained values of pH, HCO2 and TCO2 after haemodialysis (pH = 7.428 ? 0.06; HCO-3 ?= 25.4 ? 3.44 mmol/L; TCO2 = 26.57 ? 3.56 mmol/L), were significantly increased (p<0.001), in relation to values before haemodialysis (pH = 7.350 ? 0.05; HCO-3 ?= 20.88 ? 2.92 mmol/L; TCO2 = 22.03 ? 3.00 mmol/L). There was no statistically significant difference in values of measured parameters (p>0.05) in relation to underlying disease either before or after haemodialysis both in males and females.

scholarly journals Effect of an acute oral protein load on renal acidification in healthy humans and in patients with chronic renal failure.

1997 ◽  
Vol 8 (5) ◽  
pp. 784-792
Author(s):  
N G de Santo ◽  
G Capasso ◽  
G Malnic ◽  
P Anastasio ◽  
L Spitali ◽  
...  
Keyword(s):  
Renal Failure ◽  
Metabolic Acidosis ◽  
Chronic Renal Failure ◽  
Urinary Excretion ◽  
Healthy Subjects ◽  
Tubular Reabsorption ◽  
Renal Tubules ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance

The effect of a meat load on the renal handling of acid-base balance was studied in ten healthy subjects (GFR by inulin clearance = 98.5 +/- 8.14 ml.min-1.1.73 m-2) and in ten patients affected by chronic renal failure (CRF) (GFR = 39.9 +/- 5.3 ml.min-1.1.73 m-2). After the meat load (2 g.kg-1 body weight of cooked unsalted red meat), GFR increased by 26.9% (peak value) over baseline in healthy subjects and by 32% in CRF patients. The acid-base status of the healthy subjects was in the normal range, whereas the CRF patients disclosed a slight metabolic acidosis. After a meat load, there was, in the healthy subjects, an increase in the filtered load of bicarbonate coupled to an enhanced tubular reabsorption and urinary excretion. The time course between bicarbonate load and urinary excretion was coincident. In CRF patients, the increase of bicarbonate tubular load after the meal was associated with an increase in tubular reabsorption but not in urinary excretion of this anion. The relationship between bicarbonate load and reabsorption was linear in both groups up to the highest filtered loads. Baseline titratable acidity (TA) and ammonium (NH4+) excretion (expressed per ml GFR) were increased in CRF patients as compared with control subjects, but no changes were found after the meat load in both groups in these experimental conditions. The data indicate that the renal tubules contribute to the maintenance of acid-base balance both in healthy subjects and in CRF patients by reabsorbing most of the additional bicarbonate load. The transient, but significant, increase in bicarbonate excretion observed in healthy subjects could be related to the increased tubular load of bicarbonate. In CRF patients, tubular bicarbonate reabsorption was more complete, possibly because of the stimulation of H+ secretion by the mild metabolic acidosis. TA and NH4+ did not participate in tubular compensation of the increased buffer load.

Dose-related effects of metformin on acid–base balance and renal function in patients with diabetes who develop acute renal failure: a cross-sectional study

2016 ◽  
Vol 53 (4) ◽  
pp. 551-558 ◽  
Author(s):  
David Cucchiari ◽  
Manuel Alfredo Podestà ◽  
Elisa Merizzoli ◽  
Albania Calvetta ◽  
Emanuela Morenghi ◽  
...  
Keyword(s):  
Renal Failure ◽  
Renal Function ◽  
Acute Renal Failure ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Acid Base Balance ◽  
Acid Base ◽  
Cross Sectional ◽  
Patients With Diabetes ◽  
Base Balance

Acid-base Balance in Combined Severe Hepatic and Renal Failure: A Quantitative Analysis

2008 ◽  
Vol 31 (4) ◽  
pp. 288-294 ◽  
Author(s):  
T. Naka ◽  
R. Bellomo ◽  
H. Morimatsu ◽  
J. Rocktaschel ◽  
L. Wan ◽  
...  
Keyword(s):  
Renal Failure ◽  
Quantitative Analysis ◽  
Acid Base Balance ◽  
Acid Base ◽  
Base Balance
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