Altered Cellular Calcium Metabolism in Hypertension: A Reassessment and a Hypothesis

2015 ◽  
pp. 35-47
Author(s):  
Massimo Cirillo ◽  
Giovambattista Capasso ◽  
Natale Gaspare De Santo
Keyword(s):  
Calcium Metabolism ◽  
Cellular Calcium

scholarly journals Stimulation of calcium-ATPase activity by 3,5,3′-tri-iodothyronine in rat thymocyte plasma membranes. A possible role in the modulation of cellular calcium concentration

1989 ◽  
Vol 261 (3) ◽  
pp. 749-754 ◽  
Author(s):  
J Segal ◽  
J Hardiman ◽  
S H Ingbar
Keyword(s):  
Atpase Activity ◽  
Calcium Metabolism ◽  
Plasma Membranes ◽  
Calcium Concentration ◽  
Free Calcium ◽  
Physiological Concentration ◽  
Calmodulin Antagonist ◽  
Adrenergic Agents ◽  
Cellular Calcium ◽  
Free Calcium Concentration

We have previously demonstrated that 3,5,3′-tri-iodo-L-thyronine (T3) produces a very rapid and transient increase in calcium uptake and cytoplasmic free calcium concentration in the rat thymocyte, and have postulated that Ca2+-ATPase may contribute to the overall effect of T3 on cellular calcium metabolism. In the present study, we show that in the rat thymocyte, T3 increased plasma membrane Ca2+-ATPase activity. This effect of T3 was very rapid, seen at 30 s after the addition of the hormone, and was concentration-related, evident at a physiological concentration as low as 1 pM. Evaluation of the effect of several thyronine analogues on Ca2+-ATPase activity revealed the following order of potency: D-T3 greater than or equal to 3′-isopropyl-L-T2 = L-T3 = L-T4 = D-T4 greater than L-rT3 greater than 3,5-L-T2 greater than DL-thyronine. Studies with the calmodulin antagonist trifluoperazine demonstrated that thymocyte Ca2+-ATPase activity and its stimulation by T3 are influenced by calmodulin. Other studies showed that several adrenergic agents, agonists and antagonists, had no effect on thymocyte Ca2+-ATPase activity and its stimulation by T3. From these and previous observations, we would suggest that in the rat thymocyte, the T3-induced increase in Ca2+-ATPase activity, which enhances the expulsion of calcium from the cell, plays a role in the diminution and transiency of the stimulatory effect of T3 on thymocyte calcium metabolism.

SOME ASPECTS OF THE HORMONAL CONTROL OF CELLULAR CALCIUM METABOLISM

1978 ◽  
Vol 307 (1 Calcium Trans) ◽  
pp. 391-401 ◽  
Author(s):  
Howard Rasmussen ◽  
Michael C. Gustin
Keyword(s):  
Calcium Metabolism ◽  
Hormonal Control ◽  
Cellular Calcium

scholarly journals Effect of 1α-hydroxycholecalciferol on cellular calcium metabolism of kidney cortex

1979 ◽  
Vol 75 (1) ◽  
pp. 91-98
Author(s):  
Chieko KOHDA ◽  
Kazuyo NISHIMURA ◽  
Munekazu GEMBA
Keyword(s):  
Calcium Metabolism ◽  
Kidney Cortex ◽  
Cellular Calcium

Cellular Calcium Metabolism

1983 ◽  
Vol 98 (5_Part_2) ◽  
pp. 809 ◽  
Author(s):  
HOWARD RASMUSSEN
Keyword(s):  
Calcium Metabolism ◽  
Cellular Calcium

scholarly journals CALCIUM METABOLISM IN HELA CELLS AND THE EFFECTS OF PARATHYROID HORMONE

1968 ◽  
Vol 36 (3) ◽  
pp. 567-582 ◽  
Author(s):  
André Bernard Borle
Keyword(s):  
Parathyroid Hormone ◽  
Hela Cells ◽  
Calcium Metabolism ◽  
Calcium Concentration ◽  
Calcium Uptake ◽  
Cell Monolayer ◽  
Metabolic Inhibitors ◽  
Calcium Balance ◽  
Cell Coat ◽  
Cellular Calcium

Calcium metabolism was investigated in HeLa cells. 90% of the calcium of the cell monolayer is bound to an extracellular cell coat and can be removed by trypsin-EDTA. The calcium concentration of the naked cell, freed from its coat, is 0.47 mM. The calcium concentration of the medium does not affect the concentration of the naked cell calcium. However, the calcium of the cell coat is proportional to the calcium concentration in the medium. Calcium uptake into the cell coat increases with increasing calcium concentration of the medium, whereas uptake by the naked cell is independent of the calcium of the medium. Anaerobic conditions and metabolic inhibitors do not inhibit calcium uptake by the cell, a fact suggesting that this transfer is a passive phenomenon. The calcium in the extracellular cell coat, was not affected by parathyroid hormone. In contrast, the hormone increased the cellular calcium concentration by stimulating calcium uptake or by enhancing calcium binding to some cell components. These results suggest that, contrary to current thinking, parathyroid hormone influences the cellular calcium balance by mobilizing calcium from the extracellular fluids in order to increase its concentration in some cellular compartment. It is proposed that these effects can enhance calcium transport.

Alterations of Cellular Calcium Metabolism and Calcium Binding in Hypertension and Human Cardiac Hypertrophy

1991 ◽  
pp. 523-532
Author(s):  
Paul Erne ◽  
Maryse Crabos ◽  
Dieter Engelkamp ◽  
Fritz R. Bühler ◽  
Claus W. Heizmann
Keyword(s):  
Cardiac Hypertrophy ◽  
Calcium Binding ◽  
Calcium Metabolism ◽  
Cellular Calcium
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