Differential Expression of Cell Membrane Antigens, Cytotoxic Sensitivity, and Tumorigenicity in Athymic Nude Mice of a Human Urothelial Cell Line (HCV-29) and its v-raf-Transfected Variants

1992 ◽  
pp. 231-245
Author(s):  
C. Radzikowski ◽  
A. Vangsted ◽  
J. Zeuthen
Keyword(s):  
Cell Membrane ◽  
Cell Line ◽  
Differential Expression ◽  
Nude Mice ◽  
Urothelial Cell ◽  
Athymic Nude Mice ◽  
Membrane Antigens ◽  
Human Urothelial Cell ◽  
Cell Membrane Antigens

Ultrastructure of NPC/HK1 cells heterotransplanted in athymic nude mice

1982 ◽  
Vol 40 ◽  
pp. 236-237
Author(s):  
E.C. Chew ◽  
C.L. Li ◽  
D.P. Huang ◽  
H.C. Ho ◽  
L.S. Mak ◽  
...  
Keyword(s):  
Cell Line ◽  
Nude Mice ◽  
Biopsy Specimen ◽  
Epithelial Cell Line ◽  
Present Communication ◽  
Recurrent Tumour ◽  
Athymic Nude Mice ◽  
Cell Line Establishment ◽  
Fine Structures ◽  
Well Differentiated

An epithelial cell line, NPC/HK1, has recently been established from a biopsy specimen of a recurrent tumour of the nasopharynx which was histologically diagnosed as a moderately to well differentiated squamous cell carcinoma. A definite decrease in the amount of tonofilaments and desmosomes in the NPC/HK1 cells during the cell line establishment was observed. The present communication reports on the fine structures of the NPC/HK1 cells heterotraneplanted in athymic nude mice.

Effects of trypsin on the in situ identification of epidermal cell membrane antigens

1987 ◽  
Vol 14 (6) ◽  
pp. 331-336 ◽  
Author(s):  
G. Zambruno ◽  
V. Gielen ◽  
D. Schmitt ◽  
C. Dezutter-Dambuyant ◽  
J. Thivolet
Keyword(s):  
Cell Membrane ◽  
Epidermal Cell ◽  
Membrane Antigens ◽  
Cell Membrane Antigens

Antibodies to cell membrane antigens associated with human T-cell leukemia virus in patients with AIDS

Science ◽  
1983 ◽  
Vol 220 (4599) ◽  
pp. 859-862 ◽  
Author(s):  
M Essex ◽  
M. McLane ◽  
T. Lee ◽  
L Falk ◽  
C. Howe ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Membrane ◽  
Leukemia Virus ◽  
T Cell Leukemia ◽  
Cell Leukemia ◽  
Human T Cell ◽  
T Cell Leukemia Virus ◽  
Membrane Antigens ◽  
Cell Membrane Antigens

scholarly journals Production of multiple cytokines and induction of cachexia in athymic nude mice by a new anaplastic thyroid carcinoma cell line

2003 ◽  
Vol 179 (3) ◽  
pp. 387-394 ◽  
Author(s):  
JW Chang ◽  
KY Yeh ◽  
YC Shen ◽  
JJ Hsieh ◽  
CK Chuang ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Growth Factor ◽  
Cell Line ◽  
Cancer Cell ◽  
Nude Mice ◽  
Cancer Cell Line ◽  
Anaplastic Thyroid Cancer ◽  
Thyroid Cancer Cell ◽  
Athymic Nude Mice ◽  
Thyroid Cancer Cell Line

An anaplastic thyroid cancer cell line, Thena, was recently established in our laboratory following radical thyroidectomy of a patient with anaplastic thyroid cancer. Microscopically, Thena cells were spindle-shaped or small round cells. Thena cells were reactive with cytokeratin AE1/AE3 antibodies, epithelial membrane antigen, interleukin (IL)-6, epithelial growth factor receptor, transforming growth factor (TGF)-alpha, vascular endothelial growth factor, and vimentin. Thena cells secreted high levels of IL-6, leukemia inhibitor factor (LIF), tumor necrosis factor (TNF)-alpha, and TGF-beta1 in the culture supernatants, as determined by enzyme-linked immunosorbent assay. When subcutaneously injected with Thena cells, athymic nude mice developed tumor masses in the skin within 2 weeks. Furthermore, Thena cells induced cachexia in these tumor-bearing mice. High levels of human IL-6, LIF and TGF-beta1 were detected in the mouse sera. To our knowledge, the Thena cell line is the first thyroid cancer cell line reported to induce cachexia in nude mice. This cachectic animal model is worthy of further study to explore the treatment of thyroid cancer-induced cachexia.

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