Quantitative Evaluation of the Effects of Cotransplantation of Heavily Irradiated Human Tumor Cells and of Different Immunosuppressive Measures on the Xenotransplantability of a Human Squamous-Cell Carcinoma into Athymic Nude Mice

1992 ◽  
pp. 98-107 ◽  
Author(s):  
M. Baumann ◽  
A. Pu ◽  
W. DuBois ◽  
H. D. Suit
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Quantitative Evaluation ◽  
Squamous Cell ◽  
Nude Mice ◽  
Human Tumor ◽  
Human Tumor Cells ◽  
Athymic Nude Mice ◽  
Human Squamous Cell Carcinoma

Occurrence of hypercalcemia and leukocytosis with cachexia in a human squamous cell carcinoma of the maxilla in athymic nude mice: a novel experimental model of three concomitant paraneoplastic syndromes.

1991 ◽  
Vol 9 (3) ◽  
pp. 468-477 ◽  
Author(s):  
T Yoneda ◽  
T B Aufdemorte ◽  
R Nishimura ◽  
N Nishikawa ◽  
M Sakuda ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Squamous Cell ◽  
Nude Mice ◽  
Primary Tumor ◽  
Paraneoplastic Syndromes ◽  
The Body ◽  
Tumor Bearing ◽  
Human Squamous Cell Carcinoma

Hypercalcemia and leukocytosis may occur in conjunction as paraneoplastic syndromes associated with malignant disease. Here we describe a human squamous cell carcinoma of the maxilla that was associated with hypercalcemia and leukocytosis, and also cachexia. The primary tumor was surgically removed and established in permanent cell culture. When either primary tumors or cultured tumor cells were inoculated into nude mice, the nude mice developed the same paraneoplastic syndromes as those which occurred in the patient from whom the tumor was originally derived. The plasma calcium was increased two and one-half-fold and the WBC count 30-fold, and the body weight was decreased by 45% in tumor-bearing animals. Each of these paraneoplastic syndromes was alleviated by surgical excision of the tumor, indicating that the paraneoplastic syndromes were due to a factor or factors produced by the primary tumor. The development of each of these paraneoplastic syndromes in nude mice correlated positively with the other two syndromes. We examined the organs of tumor-bearing mice and found striking histopathologic abnormalities in the bones, spleen, and liver, but no infiltration with tumor cells. The bones showed marked evidence of osteoclastic bone resorption. This model of a human tumor associated with the hypercalcemia-leukocytosis paraneoplastic syndrome, together with cachexia, should make it possible to determine the mechanisms responsible for these paraneoplastic syndromes and their relationship to each other.

scholarly journals Epithelial to Mesenchymal Transition (EMT) in a Laryngeal Squamous Cell Carcinoma of a Horse: Future Perspectives

Animals ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 2318
Author(s):  
Federico Armando ◽  
Francesco Godizzi ◽  
Elisabetta Razzuoli ◽  
Fabio Leonardi ◽  
Mario Angelone ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Tumor Cells ◽  
Squamous Cell ◽  
Epithelial To Mesenchymal Transition ◽  
Hpv Infection ◽  
Mesenchymal Transition ◽  
Human Squamous Cell Carcinoma ◽  
E6 Gene ◽  
Twist 1

Squamous cell carcinoma (SCC) is one of the most frequent tumors of skin and muco-cutaneous junctions in the horse. Equine papillomavirus type 2 (EcPV2) has been detected in equine SCC of the oral tract and genitals, and recently also in the larynx. As human squamous cell carcinoma of the larynx (SCCL), it is strongly etiologically associated with high-risk papillomavirus (h-HPV) infection. This study focuses on tumor cells behavior in a naturally occurring tumor that can undergo the so-called epithelial to mesenchymal transition (EMT). A SCCL in a horse was investigated by immunohistochemistry using antibodies against E-cadherin, pan-cytokeratin AE3/AE1, β-catenin, N-cadherin, vimentin, ZEB-1, TWIST, and HIF-1α. EcPV2 DNA detection and expression of oncogenes in SCC were investigated. A cadherin switch and an intermediate filaments rearrangement within primary site tumor cells together with the expression of the EMT-related transcription factors TWIST-1, ZEB-1, and HIF-1α were observed. DNA obtained from the tumor showed EcPV2 positivity, with E2 gene disruption and E6 gene dysregulation. The results suggest that equine SCCL might be a valuable model for studying EMT and the potential interactions between EcPV2 oncoproteins and the EMT process in SCCL.

Measurement of the survival of human tumor cells after implantation in athymic nude mice

1986 ◽  
Vol 38 (1) ◽  
pp. 97-101 ◽  
Author(s):  
J. C. Romijn ◽  
C. F. Verkoelen ◽  
F. H. Schroeder
Keyword(s):  
Tumor Cells ◽  
Nude Mice ◽  
Human Tumor ◽  
Human Tumor Cells ◽  
Athymic Nude Mice

Intranuclear filaments in xenografts of human squamous cell carcinoma in nude mice

1980 ◽  
Vol 11 (1) ◽  
pp. 87-89 ◽  
Author(s):  
Ivy Benjamin ◽  
M.W. Rana ◽  
Francisco P. Xynos ◽  
Jesse Urhahn
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Nude Mice ◽  
Human Squamous Cell Carcinoma
Sign in / Sign up

Export Citation Format

Share Document