Heat-Shock Proteins and Gamma-Delta T Cell Responses in the Central Nervous System

2015 ◽  
pp. 86-101 ◽  
Author(s):  
Dennis A. Aquino ◽  
Krzysztof Selmaj
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
T Cell ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Gamma Delta ◽  
Cell Responses ◽  
The Central Nervous System ◽  
Shock Proteins ◽  
Gamma Delta T Cell

The role of heat shock proteins Hsp70 and Hsp27 in cellular protection of the central nervous system

2005 ◽  
Vol 21 (5) ◽  
pp. 379-392 ◽  
Author(s):  
T. B. Franklin ◽  
A. M. Krueger-Naug ◽  
D. B. Clarke ◽  
A.-P. Arrigo ◽  
R. W. Currie
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Cellular Protection ◽  
The Central Nervous System ◽  
Shock Proteins

scholarly journals Heat shock proteins: Cellular and molecular mechanisms in the central nervous system

2010 ◽  
Vol 92 (2) ◽  
pp. 184-211 ◽  
Author(s):  
R. Anne Stetler ◽  
Yu Gan ◽  
Wenting Zhang ◽  
Anthony K. Liou ◽  
Yanqin Gao ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Molecular Mechanisms ◽  
The Central Nervous System ◽  
Shock Proteins

Primary Omental Gamma/Delta T-Cell Lymphoma Involving the Central Nervous System

2004 ◽  
Vol 45 (9) ◽  
pp. 1947-1950 ◽  
Author(s):  
Y Harada ◽  
S Kato ◽  
H Komiya ◽  
T Shirota ◽  
K Mukai ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
T Cell ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
Gamma Delta ◽  
The Central Nervous System ◽  
Gamma Delta T Cell

T Cells Response and Autoantibodies to Human Heat Shock Proteins in Aplastic Anemia Patients.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 2403-2403
Author(s):  
Yunfeng Cheng ◽  
Yong Tang ◽  
Neal S. Young
Keyword(s):  
Cell Proliferation ◽  
T Cells ◽  
T Cell ◽  
Heat Shock ◽  
Heat Shock Proteins ◽  
Aplastic Anemia ◽  
T Cell Proliferation ◽  
Control Group ◽  
Cell Responses ◽  
Shock Proteins

Abstract Heat shock proteins (HSP) have been implicated in autoimmune diseases such as type I diabetes mellitus, systemic lupus erythematosus, and multiple sclerosis, in which T cell proliferative responses or autoantibodies towards endogenous HSP have been detected (Journal of Autoimmunity2003;20:313). HSP70 can function as an endogenous ‘danger’ signal, acting on antigen-presenting cells and critically influencing the decision between induction of tolerance and immunity upon antigen encounter (Millar et al. Nature Medicine2003; 9:1469). We studied T-cell proliferative responses and auto-antibodies to human HSP60, HSP70 and HSP90 proteins in 20 newly diagnosed aplastic anemia patients, peripheral blood was obtained (11 females, 9 males; age average 36.1±19 years). A non-isotopic immunoassay was used for BrdU incorporation into proliferative T cells and ELISA to measure HSP antibody titer. T cell proliferation was measured as the Eu-fluorescence in a time-resolved fluorometer. A positive result was defined as > 2 standard deviations (SD) from the mean of the controls. T-cell responses to HSP70 in the patient group (N=20; mean±SD Eu-fluorescence= 47,129±36,248) were significantly greater than those of the control group (N=18 healthy adult; mean Eu-fluorescence= 23,941±12,996; p=0.01). Fifty percent of the patients showed increased T cell proliferation after HSP70 stimulation compared to 5% in the control group (p=0.03). T-cell responses of the patient group to HSP90 and HSP60 were similar to those of the control group. Twenty percent of patients showed increased T cell proliferation to HSP 60 and HSP 90 stimulation compared to 5% in the control group (p=0.363). HSP antibody (IgG/A/M) seropositivity was 25% to HSP60, 50% to HSP70, and 5% to HSP90 in patients and 8% to HSP60, 0% to HSP70, and 0% to HSP90 in controls. Heightened autoimmunity to HSP70, but not to HSP60 and HSP90, is a feature of acquired aplastic anemia at presentation.

Sign in / Sign up

Export Citation Format

Share Document