The Role of Gamma-Delta T Lymphocytes in Inflammatory Muscle Disease

2015 ◽  
pp. 75-85 ◽  
Author(s):  
Reinhard Hohlfeld ◽  
Andrew G. Engel
Keyword(s):  
T Lymphocytes ◽  
Muscle Disease ◽  
Gamma Delta ◽  
Inflammatory Muscle Disease

scholarly journals The role of gamma delta T lymphocytes in breast cancer: a review

2019 ◽  
Vol 203 ◽  
pp. 88-96 ◽  
Author(s):  
Elizabeth S. Morrow ◽  
Antonia Roseweir ◽  
Joanne Edwards
Keyword(s):  
Breast Cancer ◽  
T Lymphocytes ◽  
Gamma Delta

What is the role of T-lymphocytes with gamma/delta receptors in Pneumocystis carinii pneumonia in AIDS patients?

AIDS ◽  
1994 ◽  
Vol 8 (3) ◽  
pp. 395 ◽  
Author(s):  
O. Perrella ◽  
A. Perrella ◽  
E. Soscia ◽  
A. Marinelli ◽  
V. Mininni ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Pneumocystis Carinii Pneumonia ◽  
Pneumocystis Carinii ◽  
Gamma Delta ◽  
Aids Patients ◽  
Delta Receptors

Immunity to mycobacteria: possible role of alpha/beta and gamma/delta T lymphocytes

Apmis ◽  
1990 ◽  
Vol 98 (7-12) ◽  
pp. 669-673 ◽  
Author(s):  
A.J. Gatrill ◽  
B. Schoel ◽  
H. Gulle ◽  
K. Pfeffer ◽  
H. Wagner ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Gamma Delta ◽  
Alpha Beta

POPDC proteins and cardiac function

2019 ◽  
Vol 47 (5) ◽  
pp. 1393-1404 ◽  
Author(s):  
Thomas Brand
Keyword(s):  
Potential Role ◽  
Striated Muscle ◽  
Short Review ◽  
Effector Proteins ◽  
Muscle Disease ◽  
Disease Genes ◽  
Protein Protein Interaction ◽  
Interaction Partners ◽  
And Function

Abstract The Popeye domain-containing gene family encodes a novel class of cAMP effector proteins in striated muscle tissue. In this short review, we first introduce the protein family and discuss their structure and function with an emphasis on their role in cyclic AMP signalling. Another focus of this review is the recently discovered role of POPDC genes as striated muscle disease genes, which have been associated with cardiac arrhythmia and muscular dystrophy. The pathological phenotypes observed in patients will be compared with phenotypes present in null and knockin mutations in zebrafish and mouse. A number of protein–protein interaction partners have been discovered and the potential role of POPDC proteins to control the subcellular localization and function of these interacting proteins will be discussed. Finally, we outline several areas, where research is urgently needed.

PD-L1 Inhibitors for the Treatment of Prostate Cancer

2020 ◽  
Vol 21 (15) ◽  
pp. 1558-1565
Author(s):  
Matteo Santoni ◽  
Francesco Massari ◽  
Liang Cheng ◽  
Alessia Cimadamore ◽  
Marina Scarpelli ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Clinical Trials ◽  
T Lymphocytes ◽  
Chronic Inflammation ◽  
Immune Cells ◽  
Response To Therapy ◽  
Complex Series

The carcinogenesis of prostate cancer (PCa) results from a complex series of events. Chronic inflammation and infections are crucial in this context. Infiltrating M2 type macrophages, as well as neutrophils and T lymphocytes, contribute to PCa development, progression and response to therapy. The preliminary findings on the efficacy of immunotherapy in patients with PCa were not encouraging. However, a series of studies investigating anti-PD-L1 agents such as Atezolizumab, Avelumab and Durvalumab used alone or in combination with other immunotherapies, chemotherapy or locoregional approaches are in course in this tumor. In this review, we illustrate the role of immune cells and PD-L1 expression during PCa carcinogenesis and progression, with a focus on ongoing clinical trials on anti-PD-L1 agents in this context.

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