Growth Factors Promoting Progression in Renal Failure

2015 ◽  
pp. 184-201
Author(s):  
A. Fogo
Keyword(s):  
Renal Failure ◽  
Growth Factors

Clinical use of growth factors in chronic renal failure

2000 ◽  
Vol 9 (1) ◽  
pp. 5-10 ◽  
Author(s):  
Anitha Vijayan ◽  
Terry Behrend ◽  
Steven B. Miller
Keyword(s):  
Renal Failure ◽  
Growth Factors ◽  
Chronic Renal Failure ◽  
Clinical Use

Bcl-2 genes and growth factors in the pathology of ischaemic acute renal failure

1999 ◽  
Vol 77 (3) ◽  
pp. 279-286 ◽  
Author(s):  
G Gobé ◽  
X-J Zhang ◽  
L Cuttle ◽  
B Pat ◽  
D Willgoss ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Growth Factors

Acute renal failure. III. The role of growth factors in the process of renal regeneration and repair

2000 ◽  
Vol 279 (1) ◽  
pp. F3-F11 ◽  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Growth Factors ◽  
Experimental Models ◽  
Future Research ◽  
Expression Of Genes ◽  
Genes Encoding ◽  
Renal Regeneration ◽  
General Studies

This review, which is the final installment in a series devoted to controversial issues in acute renal failure (ARF) (3, 47), will examine available information regarding the role of growth factors in ARF. In general, studies in this area have fallen into two broad categories: 1) those that have examined the renal expression of genes encoding growth factors or transcriptional factors associated with the growth response that is induced after ARF, and 2) those that have examined the efficacy of exogenously administered growth factors in accelerating recovery of renal function in experimental models of ARF. Despite the vast amount of information that has accumulated in these two areas of investigation, our understanding of the mechanisms involved in the process of regeneration and repair after ARF, and the role of growth factors in this response, remains rudimentary. This overview, contributed to by a number of experts in the field, is designed to summarize present knowledge and to highlight potentially fertile areas for future research in this area.

scholarly journals Relationship between Expression of Bcl-2 Genes and Growth Factors in Ischemic Acute Renal Failure in the Rat

2000 ◽  
Vol 11 (3) ◽  
pp. 454-467
Author(s):  
GLENDA GOBÉ ◽  
XIAO-JU ZHANG ◽  
DESLEY A. WILLGOSS ◽  
ESTELLE SCHOCH ◽  
NICOLE A. HOGG ◽  
...  
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Growth Factors ◽  
Growth Factor ◽  
Distal Tubule ◽  
Proximal Tubules ◽  
Moderate Increase ◽  
Paracrine Action ◽  
Distal Tubules ◽  
Low Expression

Abstract. The promotion of cell survival and regeneration in acute renal failure (ARF) is important for restitution of renal function. This study analyzes the temporal and spatial relationship between expression of pro- and anti-apoptotic members of the Bcl-2 gene family (Bcl-2, Bcl-XL, Bax) and epidermal growth factor (EGF), insulin-like growth factor-1 (IGF-1), and transforming growth factor-β (TGF-β), growth factors that are thought to be reparative in ARF. A rat model of ischemic ARF involving 30 min of bilateral renal artery occlusion followed by reperfusion for 0 to 14 d was used. Apoptosis and mitosis were quantified and qualitative assessment was made of other cellular damage including necrosis and loss of cellular adhesion. Locality and level of expression of the Bcl-2 and growth factor proteins were determined using immunohistochemistry. Apoptosis peaked between 4 and 14 d postischemia in both proximal and distal tubules. Mitosis peaked at 2 d in proximal tubules and 4 to 14 in the distal tubules. A spatio-temporal relationship was observed between anti-apoptotic Bcl-2 gene family members and growth factors after ischemia-reperfusion. In control kidneys, expression of Bcl-2, Bcl-XL was low in epithelium of distal tubules, Bax had low-to-moderate expression in the proximal tubule and had low expression in the distal tubule, EGF and IGF-1 had low-to-moderate expression in the distal tubule, and TGF-β had low expression in the proximal tubule. In contrast, within 24 h of reperfusion, distal tubules showed a marked increase in expression of Bcl-2 and a moderate increase in Bcl-XL and Bax. Proximal tubules showed a marked increase in Bax expression and a moderate increase in Bcl-XL. Twenty-four hours after expression of the Bcl-2 proteins was increased, IGF-1 and EGF protein levels were increased in the distal tubule, similar to the Bcl-2 anti-apoptotic proteins, and were also detected in the adjacent proximal tubules, suggestive of paracrine action in these tubules. TGF-β expression was moderately increased in regenerating proximal tubules, but no relationship was seen with the pattern of expression of the Bcl-2 genes. An explanation of these results is that the distal tubule is adaptively resistant to ischemic injury via promotion of survival by anti-apoptotic Bcl-2 genes, and its survival allows expression of growth factors critical not only to the maintenance and regeneration of its own cell population (autocrine action), but also to the adjacent ischemia-sensitive proximal tubular cells (paracrine action).

Role of growth factors in acute renal failure

1997 ◽  
Vol 12 (8) ◽  
pp. 1560-1563 ◽  
Author(s):  
S. Wang ◽  
R. Hirschberg
Keyword(s):  
Renal Failure ◽  
Acute Renal Failure ◽  
Growth Factors
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