Paediatric Oncology: The Optimal Model for Evaluating Radiation-Chemotherapy Interactions

2015 ◽  
pp. 162-171
Author(s):  
C. J. H. Fryer
Keyword(s):  
Paediatric Oncology ◽  
Optimal Model

Dental Development in Children After Chemotherapy

2017 ◽  
Vol 68 (6) ◽  
pp. 1397-1400
Author(s):  
Cristina Bica ◽  
Mihaela Chincesan ◽  
Daniela Esian ◽  
Krisztina Martha ◽  
Valentin Ion ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Tooth Development ◽  
Lymphoblastic Leukemia ◽  
Treatment Method ◽  
Paediatric Oncology ◽  
Structural Defects ◽  
Dental Development ◽  
Cytostatic Agents ◽  
Dental Abnormalities ◽  
Tooth Buds

Chemotherapy, as a treatment method in paediatric oncology, coincides with the physiological process of tooth development. The interference between cytostatic agents and the cycle of the cells with specialised functions in the formation and mineralisation of dental structures leads to the appearance of abnormalities in the development of the tooth buds, structural defects and disorderly eruption. We have looked into the distribution of developmental tooth disorders in a group of children suffering from malignant ailments. The study reveals a high occurrence of microdontia and agenesis of premolars among children diagnosed with high-risk acute lymphoblastic leukemia at the age between 1 and 6, as well as tooth eruption disturbances in 70% of the children. The nature and the severity of dental abnormalities depend on the type of cytostatic medication, the dosage and the frequency of therapeutic cycles, the age of the child at the beginning of the oncological therapy, as well as on the stage of the odontogenesis.

scholarly journals An Optimal Model to Meet the Hourly Peak Demands of a Specific Region With Solar, Wind, and Grid Supplies

IEEE Access ◽  
2020 ◽  
Vol 8 ◽  
pp. 13179-13194
Author(s):  
B. Priyadharshini ◽  
Velappa Ganapathy ◽  
Priyanka Sudhakara
Keyword(s):  
Solar Wind ◽  
Specific Region ◽  
Optimal Model

Optimal model-free fuzzy logic control for autonomous unmanned aerial vehicle

2021 ◽  
pp. 095441002110253
Author(s):  
Hossam E Glida ◽  
Latifa Abdou ◽  
Abdelghani Chelihi ◽  
Chouki Sentouh ◽  
Gabriele Perozzi
Keyword(s):  
Fuzzy Logic ◽  
Unmanned Aerial Vehicle ◽  
Fuzzy Logic Control ◽  
Estimation Error ◽  
Design Parameters ◽  
Multiple Model ◽  
Optimal Model ◽  
Model Free ◽  
Logic Control ◽  
Aerial Vehicle

This article deals with the issue of designing a flight tracking controller for an unmanned aerial vehicle type of quadrotor based on an optimal model-free fuzzy logic control approach. The main design objective is to perform an automatic flight trajectory tracking under multiple model uncertainties related to the knowledge of the nonlinear dynamics of the system. The optimal control is also addressed taking into consideration unknown external disturbances. To achieve this goal, we propose a new optimal model-free fuzzy logic–based decentralized control strategy where the influence of the interconnection term between the subsystems is minimized. A model-free controller is firstly designed to achieve the convergence of the tracking error. For this purpose, an adaptive estimator is proposed to ensure the approximation of the nonlinear dynamic functions of the quadrotor. The fuzzy logic compensator is then introduced to deal with the estimation error. Moreover, the optimization problem to select the optimal design parameters of the proposed controller is solved using the bat algorithm. Finally, a numerical validation based on the Parrot drone platform is conducted to demonstrate the effectiveness of the proposed control method with various flying scenarios.

scholarly journals Solitary tibial lesion as the initial presentation of Langerhans cell histiocytosis: report of two cases and literature review

2021 ◽  
Vol 49 (1) ◽  
pp. 030006052098282
Author(s):  
Chih-Yang Lin ◽  
Chia-Che Lee ◽  
Kuan-Wen Wu ◽  
Chang-Tsu Yuan ◽  
Ken-Nan Kuo ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Langerhans Cell Histiocytosis ◽  
Paediatric Oncology ◽  
Bone Diseases ◽  
Langerhans Cell ◽  
Oncology Group ◽  
Preventive Chemotherapy ◽  
System Risk ◽  
Risk Patients

The various presentations of osseous Langerhans cell histiocytosis (LCH) make it difficult to distinguish from other bone diseases. In addition, there is no universally accepted protocol for managing osseous LCH for single non-central nervous system-risk lesions. Here, the rare cases of two paediatric patients, aged 1 and 2 years, who presented with a solitary tibial lesion at time of LCH diagnosis, are reported. One patient progressed to multiple lesions after curettage of the original lesion. Subsequently, both patients received preventive chemotherapy using the Taiwan Paediatric Oncology Group (TPOG) revised protocol for treating low risk patients with LCH, namely, TPOG LCH2002-LR. After receiving this treatment, which included a schedule of prednisolone and vincristine for 6 weeks, followed by prednisolone, vincristine and 6-mercaptopurine for a further 48 weeks, both patients are free from recurrence or progression.

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