Role of Immunological Tests in Diagnosis of Bacterial Meningitis

2015 ◽  
pp. 68-78 ◽  
Author(s):  
R. Ringelmann ◽  
B. Heym ◽  
E. Kniehl
Keyword(s):  
Bacterial Meningitis ◽  
Immunological Tests

scholarly journals Iatrogenic bacterial meningitis: an unmasked threat

CJEM ◽  
2012 ◽  
Vol 14 (04) ◽  
pp. 263-266 ◽  
Author(s):  
Robert Barnwell ◽  
Vincent Ball
Keyword(s):  
Emergency Department ◽  
Bacterial Meningitis ◽  
Spinal Anesthesia ◽  
Lumbar Puncture ◽  
Epidural Anesthesia ◽  
Emergency Physician ◽  
Rapid Diagnosis ◽  
Treatment And Prevention ◽  
Sterile Technique

ABSTRACT Iatrogenic bacterial meningitis (IBM) is a rare but serious complication of neuraxial procedures, such as spinal and epidural anesthesia or lumbar puncture. We report a case of a 46-year-old female who presented to the emergency department with bacterial meningitis after spinal anesthesia. We reviewthe existing literature outlining the pathogenesis, vector hypothesis, diagnosis, treatment, and prevention as they relate to IBM. We highlight the role of the emergency physician in the rapid diagnosis of this disease, and underscore the need for sterile technique when performing lumbar punctures.

scholarly journals Clinical Prognosis in Neonatal Bacterial Meningitis: The Role of Cerebrospinal Fluid Protein

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0141620 ◽  
Author(s):  
Jintong Tan ◽  
Juan Kan ◽  
Gang Qiu ◽  
Dongying Zhao ◽  
Fang Ren ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Bacterial Meningitis ◽  
Clinical Prognosis ◽  
Cerebrospinal Fluid Protein

A enfermagem militar no enfrentamento à COVID-19 em comunidades indígenas

2021 ◽  
Vol 11 (34) ◽  
pp. 318-323
Author(s):  
Jessica Bernardes Almeida Borges da Silva dos Reis ◽  
Camila Bento Silva ◽  
Bianca Rafaela Correia ◽  
Vanessa De Almeida Ferreira Corrêa ◽  
Renata Flavia Abreu da Silva
Keyword(s):  
Health Care ◽  
Indigenous Health ◽  
Armed Forces ◽  
Military Nurses ◽  
Professional Performance ◽  
Immunological Tests ◽  
The World ◽  
Host Health ◽  
Military Nursing

Descrever a experiência de enfermeiras militares na Operação Xavante no enfrentamento ao novo Coronavírus. Trata-se de um relato de experiência sobre a atuação de enfermeiras militares na Operação Xavante. Como parte de uma equipe multidisciplinar, a enfermagem militar na Operação Xavante foi primordial em várias frentes de atuação, as quais permitiram, dentro do contexto proposto, o adequado cumprimento da missão e o sucesso das ações de saúde planejadas, destacando-se nos seguintes aspectos: recepção e triagem; acolhimento; educação em saúde e realização de testes imunológicos para a COVID-19. Enfatiza-se que estas ações fazem parte da atuação profissional das enfermeiras integrantes das Forças Armadas, atuando em diferentes situações e contextos, possibilitando reafirmar as práticas de enfermagem na atenção à saúde indígena, em meio a um momento de extremo desafio vivenciado pela população mundial.Descritores: Enfermagem Militar, Infecções por Coronavirus, Saúde de Populações Indígenas, Grupos Populacionais. Military nursing in the fight against COVID-19 in indigenous communitiesAbstract: To describe the experience of military nurses in Operation Xavante in coping to the new Coronavirus. This is an experience report on the role of military nurses in Operation Xavante. As part of a multidisciplinary team, military nursing in Operation Xavante was primordial on several fronts of action, which allowed, within the proposed context, the proper fulfillment of the mission and the success of the planned health actions, standing out in the following aspects: reception and screening; host; health education and immunological tests for COVID-19. It ends by emphasizing that these actions are part of the professional performance of nurses who are members of the Armed Forces, working in different situations and contexts, making it possible to reaffirm nursing practices in indigenous health care, amid a moment of extreme challenge experienced by the world population.Descriptors: Military Nursing, Coronavirus Infections, Health of Indigenous People, Population Groups. La enfermería militar en la lucha contra el COVID-19 en comunidades indígenasResumen: Describir la experiencia de las enfermeras militares en la Operación Xavante frente al nuevo Coronavirus. Este es un informe de experiencia sobre el papel de las enfermeras militares en la Operación Xavante. Como parte de un equipo multidisciplinario, la enfermería militar en la Operación Xavante fue primordial en varios frentes de acción, lo que permitió, dentro del contexto propuesto, el adecuado cumplimiento de la misión y el éxito de las acciones de salud planificadas, destacándose en los siguientes aspectos: recepción y selección; acogida; educación en salud y realización de pruebas inmunológicas para COVID-19. Finalizase enfatizando que estas acciones son parte del desempeño profesional de las enfermeras integrantes de las Fuerzas Armadas, actuando en diferentes situaciones y contextos, posibilitando reafirmar las prácticas de enfermería en la atención a la salud indígena, en un momento de desafío extremo que vive la población mundial.Descriptores: Enfermería Militar, Infecciones por Coronavirus, Salud de Poblaciones Indígenas, Grupos Poblacionales.

scholarly journals Cerebral Ischemia in Experimental Neonatal Bacterial Meningitis: Role of Endothelin-Mediated Increased Cerebrovascular Resistance

1999 ◽  
Vol 45 (4, Part 2 of 2) ◽  
pp. 274A-274A
Author(s):  
Jay H Tureen ◽  
Donna M Ferriero ◽  
Martin G Taeuber ◽  
Qingxiang Liu ◽  
Lucian Chow
Keyword(s):  
Cerebral Ischemia ◽  
Bacterial Meningitis ◽  
Cerebrovascular Resistance

scholarly journals The Potential Role of Matrix Metalloproteinases 8 and 9 and Myeloperoxidase in Predicting Outcomes of Bacterial Meningitis of Childhood

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Okko Savonius ◽  
Irmeli Roine ◽  
Saeed Alassiri ◽  
Taina Tervahartiala ◽  
Otto Helve ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Cerebrospinal Fluid ◽  
Matrix Metalloproteinases ◽  
Bacterial Meningitis ◽  
Confidence Interval ◽  
Potential Role ◽  
Tissue Inhibitor Of Metalloproteinase ◽  
Inflammatory Cascade ◽  
Disease Outcomes

Background. Matrix metalloproteinases (MMPs) and myeloperoxidase (MPO) contribute to the inflammatory cascade in the cerebrospinal fluid (CSF) during bacterial meningitis. We determined levels of MPO, MMP-8, MMP-9, and tissue inhibitor of metalloproteinase- (TIMP-) 1 in the CSF of children with bacterial meningitis and investigated how these inflammatory mediators relate to each other and to the disease outcomes. Methods. Clinical data and the diagnostic CSF samples from 245 children (median age eight months) with bacterial meningitis were obtained from a clinical trial in Latin America in 1996–2003. MMP-9 levels in the CSF were assessed by zymography, while MMP-8, MPO, and TIMP-1 concentrations were determined with immunofluorometric and enzyme-linked immunosorbent assays. Results. MPO correlated positively with MMP-8 (rho 0.496, P<0.001) and MMP-9 (rho 0.153, P=0.02) but negatively with TIMP-1 (rho -0.361, P<0.001). MMP-8 emerged as the best predictor of disease outcomes: a CSF MMP-8 concentration above the median increased the odds of death 4.9-fold (95% confidence interval 1.8–12.9). Conclusions. CSF MMP-8 presented as an attractive prognostic marker in children with bacterial meningitis.

scholarly journals Patterns of Local and Systemic Cytokines in Bacterial Meningitis and its Relation with Severity and Long-Term Sequelae

2015 ◽  
Vol 10 ◽  
pp. BMI.S35005 ◽  
Author(s):  
Federico Perdomo-Celis ◽  
Miguel A. Torres ◽  
Henry Ostos ◽  
Javier Gutierrez-Achury ◽  
Victor Molano ◽  
...  
Keyword(s):  
Bacterial Meningitis ◽  
Clinical Severity ◽  
Clinical Role ◽  
Strong Negative Correlation ◽  
Neurological Sequelae ◽  
Flow Cytometric ◽  
Factor Α ◽  
To Receive

Bacterial meningitis (BM) is a pyogenic infection present in the subarachnoid space, potentially fatal and frequently associated with neurological sequelae. During BM, cytokines (CTs) are locally produced. We sought to determine the CTs’ clinical role as disease severity predictors in adults, which is not completely clear. Using a bead-based flow cytometric assay, levels of six CTs were determined in cerebrospinal fluid (CSF) and plasma from 18 adult BM patients and 19 uninfected controls. Long-term neurological sequelae were evaluated using the Glasgow Outcome Scale (GOS). All evaluated CTs were higher in CSF than in plasma, and the levels of CSF interleukin (IL)-6, IL-8, IL-10, IL-1β, and tumor necrosis factor-α and plasma IL-10 and IL-12p70 were significantly higher in patients with severe sepsis than with sepsis, suggesting an association with clinical severity. There was a strong negative correlation between CSF IL-6 and plasma IL-12p70 with GOS score, supporting the possible role of these CTs in the development of neurological long-term sequelae. These findings could be helpful to identify candidates to receive neuroprotective treatments and early physiotherapy schemes.

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