Wegener�s Granulomatosis, Microscopic Polyarteritis and Pauciimmune Crescentic Necrotizing Glomerulonephritis

2015 ◽  
pp. 1-12 ◽  
Author(s):  
Eberhard Ritz ◽  
Konrad Andrassy ◽  
Sonja K�ster ◽  
R�diger Waldherr
Keyword(s):  
Necrotizing Glomerulonephritis ◽  
Microscopic Polyarteritis

scholarly journals Pauci-immune necrotizing glomerulonephritis in a patient with ankylosing spondylitis

Nefrología ◽  
2021 ◽  
Author(s):  
Beyhan Güvercin ◽  
Kubra Kaynar ◽  
Hasibe Bilge Gür ◽  
Sevdegül Mungan ◽  
Emre Selim ◽  
...  
Keyword(s):  
Ankylosing Spondylitis ◽  
Necrotizing Glomerulonephritis

MPO-ANCA necrotizing glomerulonephritis related to rheumatoid arthritis

1998 ◽  
Vol 32 (5) ◽  
pp. e6.1-e6.5 ◽  
Author(s):  
T Messiaen ◽  
P M'bappe ◽  
JJ Boffa ◽  
R Khayat ◽  
B Mougenot ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Necrotizing Glomerulonephritis

scholarly journals AN AUTOPSY CASE OF MICROSCOPIC POLYARTERITIS NODOSA

1980 ◽  
Vol 69 (6) ◽  
pp. 738-744
Author(s):  
Hidemitsu MATSUURA ◽  
Takayoshi TANABE ◽  
Hiroyuki OHMORI ◽  
Tsuneo NANBA ◽  
Katsuhiko KIMOTO ◽  
...  
Keyword(s):  
Polyarteritis Nodosa ◽  
Autopsy Case ◽  
Microscopic Polyarteritis

scholarly journals A case of microscopic polyarteritis associated with recurrent pulmonary hemorrhage.

1991 ◽  
Vol 38 (4) ◽  
pp. 389-395
Author(s):  
Ji Youn Bae ◽  
Sang Soon Lim ◽  
Yoon Suk Lee ◽  
Kwang Ho In ◽  
Se Hwa Yoo ◽  
...  
Keyword(s):  
Pulmonary Hemorrhage ◽  
Microscopic Polyarteritis

scholarly journals Severe course of quickly progressing glomerulonephritis in a patient with ANTSA-associated vasculitis: review and case report

2020 ◽  
Vol 7 (3) ◽  
pp. 55-62
Author(s):  
Iu. V. Lavrishcheva ◽  
Y. S. Kaledinova ◽  
A. A. Yakovenko ◽  
I. A. Artemev
Keyword(s):  
Granulomatosis With Polyangiitis ◽  
Rapidly Progressive Glomerulonephritis ◽  
Granulomatous Inflammation ◽  
Clinical Work ◽  
Chronic Hemodialysis ◽  
Complete Loss ◽  
Vascular Lesions ◽  
Upper Respiratory Tract ◽  
Delay In Diagnosis ◽  
Necrotizing Glomerulonephritis

Granulomatosis with polyangiitis is characterized by necrotizing granulomatous inflammation, vasculitis with vascular lesions of small and medium caliber and focal necrotizing glomerulonephritis. A frequent and one of the most formidable complications is kidney damage, which in a large number of cases leads to a complete loss of organ function and a switch to renal replacement therapy. Given the rare occurrence of this disease in the clinical work of practitioners, and their low awareness of this pathology, problems often arise with the diagnosis and treatment of patients with HPA. Due to the diversity and non-specific nature of the manifestations of the disease, a delay in diagnosis may occur. The presented case illustrates the manifestations of granulomatosis with polyangiitis in the form of severe damage to the upper respiratory tract and kidneys, the diagnosis of which was difficult due to the rarity of the disease and the multiple organ pathology. This article presents a clinical case of severe progression of rapidly progressive glomerulonephritis in a patient with ANCA-associated vasculitis, a brief review of the literature is given. Despite adequate therapy, the disease progressed mainly due to deterioration of renal function, which subsequently led to a complete loss of kidney function and the transition to treatment with chronic hemodialysis.

Microscopic Polyarteritis

1992 ◽  
Vol 128 (9) ◽  
pp. 1223 ◽  
Author(s):  
Pamela Bostic Homas
Keyword(s):  
Microscopic Polyarteritis

scholarly journals MO038ANTIMYELOPEROXIDASE AND PROTEINASE 3 ANTIBODIES ARE A USEFUL MARKER AS NEPHRITIS FLARE PREDICTOR IN ANCA-ASSOCIATED VASCULITIS

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
Eva Rodriguez ◽  
Ana Belén Latze ◽  
Milagros Sierra ◽  
Ana María Romera ◽  
Diego Siedel ◽  
...  
Keyword(s):  
Roc Curve ◽  
Renal Involvement ◽  
Continuous Variable ◽  
Multiplex Assay ◽  
Anca Associated Vasculitis ◽  
Renal Flare ◽  
Necrotizing Glomerulonephritis ◽  
Renal Vasculitis ◽  
Renal Relapse ◽  
Antibody Levels

Abstract Background and Aims The diagnostic utility of ANCA antibodies in ANCA associated-vasculitis (AAV), antiproteinase 3 (PR3) and myeloperoxidase (MPO) testing is now undisputed, but the clinical utility of serial MPO/PR3 testing to predict relapses, remain controversial. The aim of this study was to analyze the relevance of serum MPO and PR3 antibody level assessment in the management of AAV. We sought to determine whether MPO and PR3 antibody levels correlated with renal disease activity, and whether an increase could predict a nephritis flare. Method Retrospective multicenter study including AAV-patients with renal involvement from 7 nephrology departments belonging to the Spanish Glomerular Study Group (GLOSEN). The main inclusion criteria were that MPO antibodies were detected by ELISA (Multiplex assay) and PR3 using chemioluminescence immunoassay. For statistical purpose a continuous variable were calculated, called delta MPO/PR3(ΔMPO y ΔPR3) that reflects change in antibodies levels 6 months before renal flare. Clinical data were recorded since complete remission of first nephritis diagnosis flare until second renal relapse. Results 113 AAV-patients with pauci-inmune necrotizing glomerulonephritis were included, 59 (52.2%) women, mean age (64.3±14.8 years), 85 patients (75.2%) MPO-AAV and 28 (24.8%) PR3-AAV, after a mean follow-up of 5±4.8 years, 54 renal relapses occurred in 40 (52,6%) MPO-AAV patients and in 14 (57.1%) PR3-AAVpatients. Serum MPO levels were significant higher in relapser-patients compared with non- relapser patients, 3±1.2 months before nephritis relapse [(n=32) 19.2±12.2 IA vs (n=38) 3.2±5.1 IA, p<0.001)]. Δ MPO levels were significant higher in relapse-patients compared with non-relapser patients [(n=32) 8.3±12 IA vs (n=38) 0.9±3.1.1 IA, p=0.001). The discrimination value of the MPO antibody levels 3 months before renal relapse were established by means of a ROC curve: AUC of 0.82 (95% CI 0.73 to 0.92; p<0.001) and the MPO cut-off value predicting renal relapse were established in 8.3 IA. The discrimination value of the ΔMPO were established by means of ROC curve: AUC of 0.76 (95% CI 0.63 to 0.88; p<0.001), ΔMPO cut-off value were established in an increase of MPO levels of 3.7 IA. Serum PR3 levels were significant higher in relapser-patients 2.8±1.4 months before relapse [(n=14) 58.6±6.6 IA vs (n=7) 2.0±0.6 IA, p<0.001)] and Δ PR3 levels were significant higher in relapse-patients compared with non-relapser patients [(n=14) 57.5±28.5 IA vs (n=7) 0.8±0.2. IA, p<0.001)]. The discrimination value of the PR3 3 months before flare and Δ PR3 antibody levels were established by means of ROC curve: AUC 1. Conclusion Our results show that MPO antibodies, measured by Multiplex assay, could be a useful predictor of glomerulonephritis flare in AAV-patients. MPO levels 3 months before renal flare seems a good marker confirmed by ROC curve results, MPO cut-off value with the best sensitivity and specificity in predicting renal relapse was established in 8.3 IA. Δ MPO levels show that increase in titers ≥ 3.7 IA 6 months before renal flare, predict nephritis relapse However, PR3 antibodies are not a useful predictor marker, rise in antibodies level indicate renal vasculitis activity.

The Spectrum of Diseases Associated With Necrotizing Glomerulonephritis and Its Prognosis

1985 ◽  
Vol 6 (6) ◽  
pp. 387-396 ◽  
Author(s):  
P.S. Parfrey ◽  
T.A. Hutchinson ◽  
S. Jothy ◽  
B.C. Cramer ◽  
J. Martin ◽  
...  
Keyword(s):  
Necrotizing Glomerulonephritis
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