Enhancement of Nonspecific Resistance against Microbial Infections with Special Reference to Pseudomonas aeruginosa Infection by Chemically Synthesized Lipid A-Subunit Analogs

2015 ◽  
pp. 203-208 ◽  
Author(s):  
M. Matsuura ◽  
J. Y. Homma
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Special Reference ◽  
Lipid A ◽  
Nonspecific Resistance ◽  
Microbial Infections ◽  
A Subunit ◽  
Pseudomonas Aeruginosa Infection

Enhancement of nonspecific resistance to microbial infections of synthetic lipid a-subunit analogues of GLA-27 modified at the C1 position of the glucosamine backbone

1990 ◽  
Vol 12 (6) ◽  
pp. 599-603 ◽  
Author(s):  
Mitsunobu Nakatsuka ◽  
Satoru Ikeda ◽  
Yoshio Kumazawa ◽  
Motohiro Matsuura ◽  
Chiaki Nishimura ◽  
...  
Keyword(s):  
Lipid A ◽  
Nonspecific Resistance ◽  
Microbial Infections ◽  
A Subunit

Enhancement of nonspecific resistance to viral infection by chemically synthesized lipid A-subunit analogs with different backbone structures and acyl groups

1988 ◽  
Vol 10 (4-5) ◽  
pp. 167-178 ◽  
Author(s):  
Satoru Ikeda ◽  
Yoshio Kumazawa ◽  
Chiaki Nishimura ◽  
Mitsunobu Nakatsuka ◽  
J.Yuzuru Homma ◽  
...  
Keyword(s):  
Viral Infection ◽  
Lipid A ◽  
Nonspecific Resistance ◽  
A Subunit ◽  
Resistance To Viral Infection

The effect of the antiinflammatory IL-1R antagonist anakinra in mice with CF-like lung disease and Pseudomonas aeruginosa infection

Pneumologie ◽  
2016 ◽  
Vol 70 (07) ◽  
Author(s):  
A Schütte ◽  
Z Zhou-Suckow ◽  
J Schatterny ◽  
S Schmidt ◽  
S Hassel ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Lung Disease ◽  
Pseudomonas Aeruginosa Infection

scholarly journals Epidemiology of first/new Pseudomonas aeruginosa infection in cystic fibrosis patients

2010 ◽  
Vol 9 ◽  
pp. S29 ◽  
Author(s):  
L. Zavataro ◽  
G. Taccetti ◽  
L. Cariani ◽  
N. Ravenni ◽  
G. Braccini ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Pseudomonas Aeruginosa ◽  
Pseudomonas Aeruginosa Infection

scholarly journals Rapid evolution and host immunity drive the rise and fall of carbapenem resistance during an acute Pseudomonas aeruginosa infection

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Rachel Wheatley ◽  
Julio Diaz Caballero ◽  
Natalia Kapel ◽  
Fien H. R. de Winter ◽  
Pramod Jangir ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Efflux Pump ◽  
Rapid Evolution ◽  
Carbapenem Resistance ◽  
Host Immunity ◽  
High Definition ◽  
Loss Of Resistance ◽  
Pseudomonas Aeruginosa Infection ◽  
Second Wave

AbstractIt is well established that antibiotic treatment selects for resistance, but the dynamics of this process during infections are poorly understood. Here we map the responses of Pseudomonas aeruginosa to treatment in high definition during a lung infection of a single ICU patient. Host immunity and antibiotic therapy with meropenem suppressed P. aeruginosa, but a second wave of infection emerged due to the growth of oprD and wbpM meropenem resistant mutants that evolved in situ. Selection then led to a loss of resistance by decreasing the prevalence of low fitness oprD mutants, increasing the frequency of high fitness mutants lacking the MexAB-OprM efflux pump, and decreasing the copy number of a multidrug resistance plasmid. Ultimately, host immunity suppressed wbpM mutants with high meropenem resistance and fitness. Our study highlights how natural selection and host immunity interact to drive both the rapid rise, and fall, of resistance during infection.

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