Biochemical and Anatomic Evidence for Renal Tubule Hypermetabolism and Hypertrophy in Long-Standing Experimental Diabetes mellitus1

2015 ◽  
pp. 71-77
Author(s):  
Michael C. Chobanian ◽  
Timothy S. Kern
Keyword(s):  
Renal Tubule ◽  
Experimental Diabetes

A COMPARISON OF THE EFFECTS OF ADRENALECTOMY AND OF CHLOROTHIAZIDE IN EXPERIMENTAL DIABETES INSIPIDUS

1961 ◽  
Vol 22 (1) ◽  
pp. 77-86 ◽  
Author(s):  
G. C. KENNEDY ◽  
J. D. CRAWFORD
Keyword(s):  
Diabetes Insipidus ◽  
Distal Part ◽  
Renal Tubule ◽  
Experimental Diabetes ◽  
Free Water ◽  
Adrenal Steroids ◽  
Antidiuretic Effect ◽  
Site Of Action ◽  
A Site ◽  
Antidiuretic Action

SUMMARY Chlorothiazide and its analogues had a marked antidiuretic action in diabetes insipidus; the effect appeared to be independent of that of antidiuretic hormone. In a series of rats which had been treated with these saluretic drugs, subsequent adrenalectomy had a similar antidiuretic effect. Chlorothiazide produced little or no further antidiuresis in these adrenalectomized animals, but it prevented the restoration of polyuria which otherwise followed the administration of adrenal steroids. It is suggested that the distal part of the renal tubule where osmotically free water is released is a site of action common to chlorothiazide and corticoids.

Changes of neuromuscular transmission in smooth muscles of rats bladder with experimental diabetes

2014 ◽  
Vol 60 (2) ◽  
pp. 31-37
Author(s):  
IA Vladimirova ◽  
◽  
IB Filippov ◽  
ON Paduraru ◽  
ÉIa Shuba ◽  
...  
Keyword(s):  
Neuromuscular Transmission ◽  
Experimental Diabetes ◽  
Smooth Muscles
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