Accessory Cells in Normal Human Thymus and in Thymoma: Distribution, Immunophenotype, and Cytokine Content

2015 ◽  
pp. 171-183
Author(s):  
Luigi P. Ruco ◽  
Alberto Pisacane ◽  
Donatella Pomponi ◽  
Antonella Stoppacciaro ◽  
Carlo D. Baroni
Keyword(s):  
Human Thymus ◽  
Accessory Cells ◽  
Normal Human

scholarly journals Age-related decrease of somatostatin receptor number in the normal human thymus

2000 ◽  
Vol 279 (4) ◽  
pp. E791-E798 ◽  
Author(s):  
Diego Ferone ◽  
Rosario Pivonello ◽  
P. Martin Van Hagen ◽  
Marlijn Waaijers ◽  
Joke Zuijderwijk ◽  
...  
Keyword(s):  
Structural Changes ◽  
Somatostatin Receptor ◽  
Thymic Epithelial Cells ◽  
Thymic Involution ◽  
Human Thymus ◽  
Age Related ◽  
Tissue Homogenates ◽  
Normal Human ◽  
Receptor Number ◽  
Age Range

The thymus exhibits a pattern of aging oriented toward a physiological involution. The structural changes start with a steady decrease of thymocytes, whereas no major variations occur in the number of thymic epithelial cells (TEC). The data concerning the role of hormones and neuropeptides in thymic involution are equivocal. We recently demonstrated the presence of somatostatin (SS) and three different SS receptor (SSR) subtypes in the human thymus. TEC selectively expressed SSR subtype 1 (sst1) and sst2a. In the present study we investigated whether SSR number is age related in the thymus. Binding of the sst2-preferring ligand125I-Tyr3-octreotide was evaluated in a large series of normal human thymuses of different age by SSR autoradiography and ligand binding on tissue homogenates. The score at autoradiography and the number of SSR at membrane homogenate binding (Bmax) were inversely correlated with the thymus age ( r = −0.84, P < 0.001; r = −0.82, P < 0.001, respectively). The autoradiographic score was positively correlated with the Bmaxvalues ( r = 0.74, P < 0.001). Because the TEC number in the age range considered remains unchanged, the decrease of octreotide binding sites might be due to a reduction of sst2areceptor number on TEC. The age-related expression of a receptor involved mainly in controlling secretive processes is in line with the evidence that the major changes occurring in TEC with aging are related to their capabilities in producing thymic hormones. In conclusion, SS and SSR might play a role in the involution of the human thymus. These findings underline the links between the neuroendocrine and immune systems and support the concept that neuropeptides participate in development of cellular immunity in humans.

Cytokeratin expression in normal human thymus at different ages

1997 ◽  
Vol 47 (12) ◽  
pp. 842-847 ◽  
Author(s):  
Atsuko Masunaga ◽  
Isamu Sugawara ◽  
Hisayoshi Nakamura ◽  
Tsuyoshi Yoshitake ◽  
Shinji Itoyama
Keyword(s):  
Human Thymus ◽  
Cytokeratin Expression ◽  
Different Ages ◽  
Normal Human

Lymphocyte-rich Hassall bodies in the normal human thymus

2005 ◽  
Vol 187 (2) ◽  
pp. 175-177 ◽  
Author(s):  
Marius Raica ◽  
Anca Maria Cimpean ◽  
Svetlana Encica ◽  
Andrei Motoc
Keyword(s):  
Human Thymus ◽  
Normal Human

The ultrastructure of the normal human thymus: A study of 36 cases

1978 ◽  
Vol 190 (3) ◽  
pp. 755-781 ◽  
Author(s):  
Robert M. Bearman ◽  
Gerald D. Levine ◽  
Klaus G. Bensch
Keyword(s):  
Human Thymus ◽  
Normal Human

Structural heterogeneity and immunohistochemical profile of Hassall corpuscles in normal human thymus

2006 ◽  
Vol 188 (4) ◽  
pp. 345-352 ◽  
Author(s):  
Marius Raica ◽  
Svetlana Encică ◽  
Andrei Motoc ◽  
Anca Maria Cîmpean ◽  
Traian Scridon ◽  
...  
Keyword(s):  
Structural Heterogeneity ◽  
Human Thymus ◽  
Normal Human ◽  
Immunohistochemical Profile

scholarly journals Comparative Response of Normal Human Thymus and Lymph Node Cells to Phytohemagglutinin in Culture

Blood ◽  
1967 ◽  
Vol 29 (4) ◽  
pp. 594-607 ◽  
Author(s):  
ALAN WINKELSTEIN ◽  
CHARLES G. CRADDOCK
Keyword(s):  
Lymph Node ◽  
Proliferative Activity ◽  
Peripheral Blood Lymphocytes ◽  
Lymphoid Cells ◽  
Blood Lymphocytes ◽  
Human Thymus ◽  
Spontaneous Proliferation ◽  
Comparative Response ◽  
Lymph Node Cells ◽  
Normal Human

Abstract Human thymocytes, in short-term tissue culture, show a proliferative activity distinct from that observed by either lymph node or blood lymphocytes. As expected, the behavior of lymph node lymphocytes in culture is very similar to that of peripheral blood lymphocytes. The only difference between these 2 groups of cells was the finding of spontaneous proliferation by normal lymph node cells after 3 days in culture without phytohemagglutinin (PHA). Whereas blood and lymph node lymphocytes show a negligible uptake of H3T in the basal state, approximately 10 per cent of thymus cells incorporate H3T, indicating significant autonomous proliferation. This is unaffected by PHA and is unassociated with globulin synthesis as judged by immunofluorescent technics. After 3 days in culture, there are significantly more transformed cells and more cells which incorporate H3T into DNA in thymus cell cultures containing PHA than in the control cultures. However, the labeling index of stimulated thymus cultures is less than either the basal rate of proliferation of thymocytes or 3-day cultures of PHA stimulated blood and lymph node lymphocytes. These observations suggest that the normal human thymus contains at least two populations of lymphoid cells: a major component which shows autonomous and unsustained proliferative activity and does not respond to PHA, and a second and probably minor cellular component which transforms and proliferates in response to PHA.

Immunohistochemical characterization of nurse cells in normal human thymus

1991 ◽  
Vol 96 (6) ◽  
pp. 499-503 ◽  
Author(s):  
B. Dipasquale ◽  
G. Tridente
Keyword(s):  
Nurse Cells ◽  
Human Thymus ◽  
Normal Human
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