Growth Stimulation by Cell to Cell Contact and Growth Suppression: Two Aspects of the Biology of Transforming Growth Factors

2015 ◽  
pp. 122-142
Author(s):  
Joan Massagu� ◽  
Atanasio Pandiella ◽  
Marikki Laiho
Keyword(s):  
Growth Factors ◽  
Growth Stimulation ◽  
Growth Suppression ◽  
Cell Contact ◽  
Transforming Growth Factors

Growth factors and the primary cilium in BALB/c 3T3 cells

1987 ◽  
Vol 45 ◽  
pp. 830-831
Author(s):  
R. W. Tucker ◽  
N. S. More ◽  
S. Jayaraman
Keyword(s):  
Growth Factors ◽  
Primary Cilium ◽  
Cultured Cells ◽  
Morphological Changes ◽  
Calcium Ionophore ◽  
Growth Stimulation ◽  
Calcium Ionophore A23187 ◽  
Ionophore A23187 ◽  
3T3 Cells ◽  
Microtubule Depolymerization

The mechanisms by which polypeptide growth factors Induce DNA synthesis in cultured cells is not understood, but morphological changes Induced by growth factors have been used as clues to Intracellular messengers responsible for growth stimulation. One such morphological change has been the transient disappearance of the primary cilium, a “9 + 0” cilium formed by the perinuclear centriole in interphase cells. Since calcium ionophore A23187 also produced both mitogenesis and ciliary changes, microtubule depolymerization might explain ciliary disappearance monitored by indirect immunofluorescence with anti-tubulin antibody. However, complete resorption and subsequent reformation of the primary cilium occurs at mitosis, and might also account for ciliary disappearance induced by growth factors. To settle this issue, we investigated the ultrastructure of the primary cilium using serial thin-section electron microscopy of quiescent BALB/c 3T3 cells before and after stimulation with serum.

scholarly journals Regulation of c-myc transcription and mRNA abundance by serum growth factors and cell contact.

1986 ◽  
Vol 261 (20) ◽  
pp. 9161-9166 ◽  
Author(s):  
M Dean ◽  
R A Levine ◽  
W Ran ◽  
M S Kindy ◽  
G E Sonenshein ◽  
...  
Keyword(s):  
Growth Factors ◽  
Mrna Abundance ◽  
Cell Contact

scholarly journals Expression of transforming growth factors beta-1, beta 2 and beta 3 in human bladder carcinomas

1997 ◽  
Vol 75 (12) ◽  
pp. 1753-1760 ◽  
Author(s):  
IE Eder ◽  
A Stenzl ◽  
A Hobisch ◽  
MV Cronauer ◽  
G Bartsch ◽  
...  
Keyword(s):  
Growth Factors ◽  
Transforming Growth Factors ◽  
Human Bladder ◽  
Beta 2 ◽  
Bladder Carcinomas

The Role of Transforming Growth Factors–Beta in Cutaneous Scarring

2000 ◽  
pp. 213-226 ◽  
Author(s):  
Mamta Shah ◽  
Patricia Rorison ◽  
Mark Ferguson
Keyword(s):  
Growth Factors ◽  
Transforming Growth Factors

scholarly journals PHYSICAL EXERCISE IN THE PROMOTION OF GENE THERAPY AUXILIARY EFFECT

2021 ◽  
Vol 27 (8) ◽  
pp. 779-782
Author(s):  
Wei Shen ◽  
Xiaojun Liang
Keyword(s):  
Gene Therapy ◽  
Growth Factors ◽  
Growth Factor ◽  
Physical Exercise ◽  
Fracture Healing ◽  
Bone Morphogenetic Protein ◽  
Bone Growth ◽  
Transforming Growth Factor ◽  
Transforming Growth Factors ◽  
Morphogenetic Protein

ABSTRACT Introduction: In recent years, genetic engineering has made outstanding contributions to sports, and it has played a huge role in promoting the development of sports-related fields. Objective: We analyze the tissue source of bone growth and healing by studying the role of bone morphogenetic protein and transforming growth factors in fracture injuries caused by sports. Methods: We established a human fracture model to express the shape and content of bone morphogenetic protein and transforming growth factor during fracture healing. Results: In the fracture healing stage caused by different sports, the expression levels of the two genes are different. Bone morphogenetic protein has a high content in the osteogenesis stage of the membrane, while transforming growth factor is high in the cartilage ossification stage. Conclusion: Gene therapy for fractures caused by physical exercise has certain advantages. Osteoblasts and chondrocytes are involved in the synthesis of transforming growth factors. Level of evidence II; Therapeutic studies - investigation of treatment results.

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