Tumor Cell Subpopulation Interactions Mediated by Transforming Growth Factor � May Contribute to Clonal Dominance of Metastatically Competent Cells in Primary Tumors

2015 ◽  
pp. 100-113
Author(s):  
R. S. Kerbel ◽  
D. Theodorescu
Keyword(s):  
Growth Factor ◽  
Tumor Cell ◽  
Transforming Growth Factor ◽  
Cell Subpopulation ◽  
Primary Tumors ◽  
Competent Cells

Intestinal transformation results in transforming growth factor-beta-dependent alteration in tumor cell-cell matrix interactions

Surgery ◽  
2003 ◽  
Vol 133 (5) ◽  
pp. 568-579 ◽  
Author(s):  
David H. Berger ◽  
Christine A. O'Mahony ◽  
Hongmiao Sheng ◽  
Jinyi Shao ◽  
Daniel Albo ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tumor Cell ◽  
Transforming Growth Factor Beta ◽  
Transforming Growth Factor ◽  
Cell Matrix ◽  
Matrix Interactions ◽  
Growth Factor Beta ◽  
Cell Matrix Interactions ◽  
Cell Cell

scholarly journals Thrombopoietin Receptor Levels in Tumor Cell Lines and Primary Tumors

2010 ◽  
Vol 2010 ◽  
pp. 1-8 ◽  
Author(s):  
Connie L. Erickson-Miller ◽  
Antony Chadderton ◽  
Anna Gibbard ◽  
Jennifer Kirchner ◽  
Kodandaram Pillarisetti ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tumor Cell ◽  
Cell Lines ◽  
Hematologic Malignancies ◽  
Erythropoietin Receptor ◽  
Tumor Cell Lines ◽  
Hepatitis C Infection ◽  
Primary Tumors ◽  
Normal Tissues ◽  
Proliferation And Differentiation

Thrombopoietin (TPO) receptor agonists represent a new approach for the treatment of thrombocytopenia, which may develop as a consequence of immune thrombocytopenia, chemotherapy treatment, chronic hepatitis C infection, or myelodysplastic syndromes. There are concerns that use of certain growth factors can hasten disease progression in some types of hematologic malignancies and solid tumors. In this study, expression ofMPL(TPO-R) mRNA was examined in tumor cell lines, patient tumor samples (renal cell carcinoma, prostatic carcinoma, soft tissue and bony/cartilage sarcoma, colon cancer, and lymphoma), and normal tissues using microarray analysis and qRT-PCR.MPLmRNA is expressed at very low or undetectable levels compared with erythropoietin receptor (EPOR), human epidermal growth factor (ERBB2; HER2), and insulin-like growth factor-1 receptor (IGF1R) in these patient samples. These data suggest TPO-R agonists will likely preferentially stimulate proliferation and differentiation of cells of megakaryocytic lineage, potentially demonstrating their utility for correcting thrombocytopenia in clinical settings.

Bone-derived and recombinant transforming growth factor β′S are potent inhibitors of tumor cell growth

1987 ◽  
Vol 148 (2) ◽  
pp. 783-789 ◽  
Author(s):  
Jane E. Ranchalis ◽  
Larry Gentry ◽  
Yasushi Ogawa ◽  
Saeid M. Seyedin ◽  
John McPherson ◽  
...  
Keyword(s):  
Growth Factor ◽  
Cell Growth ◽  
Tumor Cell ◽  
Transforming Growth Factor ◽  
Transforming Growth Factor Β ◽  
Tumor Cell Growth

scholarly journals Transforming growth factor beta1 inhibits aldosterone and cortisol production in the human adrenocortical cell line NCI-H295R through inhibition of CYP11B1 and CYP11B2 expression

2003 ◽  
Vol 176 (1) ◽  
pp. 69-82 ◽  
Author(s):  
P Liakos ◽  
D Lenz ◽  
R Bernhardt ◽  
JJ Feige ◽  
G Defaye
Keyword(s):  
Angiotensin Ii ◽  
Growth Factor ◽  
Tumor Cell ◽  
Cell Line ◽  
Transforming Growth Factor ◽  
Tumor Cell Line ◽  
Mrna Levels ◽  
Adrenocortical Tumor ◽  
Adrenocortical Cell ◽  
Transforming Growth Factor Beta1

Transforming growth factor beta1 (TGFbeta1) has been shown to exert strong inhibitory effects on adrenocortical cell steroidogenesis. However, the molecular targets of TGFbeta1 in adrenocortical cells appear to differ between species. Here, we report the first characterization of the regulatory effects of TGFbeta1 on the steroidogenic functions of the human adrenocortical tumor cell line NCI-H295R. After treatment with 2 ng/ml TGFbeta1 for 24 h, basal production of corticosterone, cortisol and androstenedione was dramatically decreased. When TGFbeta1 was added simultaneously with forskolin, the production of cortisol and 11-hydroxyandrostenedione was decreased by 85% whereas that of deoxycortisol was increased. When TGFbeta1 was added simultaneously with angiotensin II, aldosterone production was reduced by 80%. We observed that TGFbeta1 strongly inhibits forskolin-induced steroid 11beta-hydroxylase activity and CYP11B1 mRNA levels, as well as angiotensin II-induced aldosterone synthase activity and CYP11B2 mRNA levels. CYP11B1 and CYP11B2 gene products thus appear as the major steroidogenic enzymes down-regulated by TGFbeta1 in the human adrenocortical tumor cell line NCI-H295R.

Thrombospondin-1 and transforming growth factor-betal promote breast tumor cell invasion through up-regulation of the plasminogen/plasmin system

Surgery ◽  
1997 ◽  
Vol 122 (2) ◽  
pp. 493-500 ◽  
Author(s):  
Daniel Albo ◽  
David H Berger ◽  
Thomas N Wang ◽  
Xiaolong Hu ◽  
Vicki Rothman ◽  
...  
Keyword(s):  
Growth Factor ◽  
Tumor Cell ◽  
Cell Invasion ◽  
Breast Tumor ◽  
Transforming Growth Factor ◽  
Tumor Cell Invasion ◽  
Breast Tumor Cell ◽  
Thrombospondin 1
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