Lack of Correlation Between TNF-Inhibition of PMN Migration and Enhanced PMN Oxidative Activity and Adherence : Implications for Mechanisms of Pentoxifylline Action

2015 ◽  
pp. 1-8 ◽  
Author(s):  
Gail W. Sullivan ◽  
Holliday T. Carper ◽  
John B. Hylton ◽  
William J. Novick ◽  
Gerald L. Mandell
Keyword(s):  
Oxidative Activity ◽  
Tnf Inhibition

Detection of Protein Oxidative Activity Using Reduced RNase A

BIO-PROTOCOL ◽  
2016 ◽  
Vol 6 (6) ◽  
Author(s):  
Magdalena Grzeszczuk ◽  
Katarzyna Bocian-Ostrzycka ◽  
Anna Lasica ◽  
E. Jagusztyn-Krynicka
Keyword(s):  
Rnase A ◽  
Oxidative Activity

Asymmetric synthesis of d-glyceric acid by an alditol oxidase and directed evolution for enhanced oxidative activity towards glycerol

2012 ◽  
Vol 96 (5) ◽  
pp. 1243-1252 ◽  
Author(s):  
Sandra Gerstenbruch ◽  
Hauke Wulf ◽  
Nina Mußmann ◽  
Timothy O’Connell ◽  
Karl-Heinz Maurer ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Directed Evolution ◽  
Oxidative Activity ◽  
Glyceric Acid

scholarly journals Melatonin Successfully Rescues the Hippocampal Molecular Machinery and Enhances Anti-oxidative Activity Following Early-Life Sleep Deprivation Injury

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 774
Author(s):  
Hung-Ming Chang ◽  
Hsing-Chun Lin ◽  
Hsin-Lin Cheng ◽  
Chih-Kai Liao ◽  
To-Jung Tseng ◽  
...  
Keyword(s):  
Sleep Deprivation ◽  
Early Life ◽  
Cognitive Activity ◽  
Oxidative Activity ◽  
Protective Effects ◽  
Long Term Effects ◽  
Ionic Distribution ◽  
Melatonin Administration ◽  
Molecular Machinery ◽  
Underlying Mechanisms

Early-life sleep deprivation (ESD) is a serious condition with severe cognitive sequelae. Considering hippocampus plays an essential role in cognitive regulation, the present study aims to determine whether melatonin, a neuroendocrine beard with significant anti-oxidative activity, would greatly depress the hippocampal oxidative stress, improves the molecular machinery, and consequently exerts the neuro-protective effects following ESD. Male weanling Wistar rats (postnatal day 21) were subjected to ESD for three weeks. During this period, the animals were administered normal saline or melatonin (10 mg/kg) via intraperitoneal injection between 09:00 and 09:30 daily. After three cycles of ESD, the animals were kept under normal sleep/wake cycle until they reached adulthood and were sacrificed. The results indicated that ESD causes long-term effects, such as impairment of ionic distribution, interruption of the expressions of neurotransmitters and receptors, decreases in the levels of several antioxidant enzymes, and impairment of several signaling pathways, which contribute to neuronal death in hippocampal regions. Melatonin administration during ESD prevented these effects. Quantitative evaluation of cells also revealed a higher number of neurons in the melatonin-treated animals when compared with the saline-treated animals. As the hippocampus is critical to cognitive activity, preserving or even improving the hippocampal molecular machinery by melatonin during ESD not only helps us to better understand the underlying mechanisms of ESD-induced neuronal dysfunction, but also the therapeutic use of melatonin to counteract ESD-induced neuronal deficiency.

Oxidative activity of primaquine metabolites on rat erythrocytes IN vitro and in vivo

1994 ◽  
Vol 47 (2) ◽  
pp. 309-316 ◽  
Author(s):  
Jeannette Vásquez-Vivar ◽  
Ohara Augusto
Keyword(s):  
Oxidative Activity ◽  
Rat Erythrocytes

Unravelling the pharmacogenomics of TNF inhibition

2018 ◽  
Vol 14 (12) ◽  
pp. 689-690
Author(s):  
Marieke J. H. Coenen
Keyword(s):  
Tnf Inhibition

scholarly journals Procyanidin A2, a polyphenolic compound, exerts anti-inflammatory and anti-oxidative activity in lipopolysaccharide-stimulated RAW264.7 cells

PLoS ONE ◽  
2020 ◽  
Vol 15 (8) ◽  
pp. e0237017
Author(s):  
Qin-Qin Wang ◽  
Hongwei Gao ◽  
Renyikun Yuan ◽  
Shan Han ◽  
Xin-Xing Li ◽  
...  
Keyword(s):  
Oxidative Activity ◽  
Raw264.7 Cells ◽  
Polyphenolic Compound ◽  
Anti Inflammatory

scholarly journals Sulodexide Protects Renal Tubular Epithelial Cells from Oxidative Stress-Induced Injury via Upregulating Klotho Expression at an Early Stage of Diabetic Kidney Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Yu Ning Liu ◽  
Jingwei Zhou ◽  
Tingting Li ◽  
Jing Wu ◽  
Shu Hua Xie ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Kidney Disease ◽  
Epithelial Cells ◽  
Diabetic Kidney Disease ◽  
Early Stage ◽  
Collaborative Study ◽  
Oxidative Activity ◽  
Dependent Manner ◽  
Diabetic Kidney ◽  
Collaborative Study Group

The hypoalbuminuric effect of sulodexide (SDX) on diabetic kidney disease (DKD) was suggested by some clinical trials but was denied by the Collaborative Study Group. In this study, the diabetic rats were treated with SDX either from week 0 to 24 or from week 13 to 24. We found that 24-week treatment significantly decreased the urinary protein and HAVCR1 excretion, inhibited the interstitial expansion, and downregulated the renal cell apoptosis and interstitial fibrosis. Renoprotection was also associated with a reduction in renocortical/urinary oxidative activity and the normalization of renal klotho expression. However, all of these actions were not observed when SDX was administered only at the late stage of diabetic nephropathy (from week 13 to 24). In vitro, advanced glycation end products (AGEs) dose-dependently enhanced the oxidative activity but lowered the klotho expression in cultured proximal tubule epithelial cells (PTECs). Also, H2O2 could downregulate the expression of klotho in a dose-dependent manner. However, overexpression of klotho reduced the HAVCR1 production and the cellular apoptosis level induced by AGEs or H2O2. Our study suggests that SDX may prevent the progression of DKD at the early stage by upregulating renal klotho expression, which inhibits the tubulointerstitial injury induced by oxidative stress.

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