Human Transferrin: Expression of Chimeric Genes in Transgenic Mice

2015 ◽  
pp. 104-108 ◽  
Author(s):  
Gwendolyn S. Adrian ◽  
Damon C. Herbert ◽  
LeAnn K. Robinson ◽  
Erle K. Adrian ◽  
Christi A. Walter ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Chimeric Genes ◽  
Human Transferrin

scholarly journals Human transferrin. Expression and iron modulation of chimeric genes in transgenic mice.

1990 ◽  
Vol 265 (22) ◽  
pp. 13344-13350
Author(s):  
G S Adrian ◽  
B H Bowman ◽  
D C Herbert ◽  
F J Weaker ◽  
E K Adrian ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Chimeric Genes ◽  
Human Transferrin

Tissue-specific and developmental regulation of rod opsin chimeric genes in transgenic mice

Neuron ◽  
1991 ◽  
Vol 6 (2) ◽  
pp. 201-210 ◽  
Author(s):  
Janis Lem ◽  
Meredithe L. Applebury ◽  
Jeffrey D. Falk ◽  
John G. Flannery ◽  
Melvin I. Simon
Keyword(s):  
Transgenic Mice ◽  
Developmental Regulation ◽  
Tissue Specific ◽  
Chimeric Genes

Neuronal Expression of chimeric genes in transgenic mice

Neuron ◽  
1988 ◽  
Vol 1 (4) ◽  
pp. 311-320 ◽  
Author(s):  
Andrew F. Russo ◽  
E. Bryan Crenshaw ◽  
Sergio A. Lira ◽  
Donna M. Simmons ◽  
Larry W. Swanson ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Chimeric Genes ◽  
Neuronal Expression

Expression of Chimeric Human Transferrin-Chloramphenicol Acetyltransferase Genes in Liver and Brain of Transgenic Mice during Development

1993 ◽  
Vol 155 (2) ◽  
pp. 452-458 ◽  
Author(s):  
Yan Lu ◽  
Laura A. Cox ◽  
Damon C. Herbert ◽  
Frank J. Weaker ◽  
Christi A. Walter ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Chloramphenicol Acetyltransferase ◽  
Human Transferrin

scholarly journals Experimental Meningococcal Sepsis in Congenic Transgenic Mice Expressing Human Transferrin

PLoS ONE ◽  
2011 ◽  
Vol 6 (7) ◽  
pp. e22210 ◽  
Author(s):  
Marek Szatanik ◽  
Eva Hong ◽  
Corinne Ruckly ◽  
Morgan Ledroit ◽  
Dario Giorgini ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Meningococcal Sepsis ◽  
Human Transferrin

scholarly journals Evidence for Multi-Organ Infection During Experimental Meningococcal Sepsis due to ST-11 Isolates in Human Transferrin-Transgenic Mice

2020 ◽  
Vol 8 (10) ◽  
pp. 1456
Author(s):  
Michael Levy ◽  
Myriam Aouiti Trabelsi ◽  
Muhamed-Kheir Taha
Keyword(s):  
Transgenic Mice ◽  
Organ Failure ◽  
Meningococcal Disease ◽  
Dynamic Imaging ◽  
Factor H ◽  
Invasive Meningococcal Disease ◽  
Human Transferrin ◽  
Multi Organ Failure ◽  
Invasive Infections ◽  
Organ Infection

The description of invasive meningococcal disease that is provoked by Neisseria meningitidis (Nm) is frequently restricted to meningitis. However, a wide panel of clinical presentations can be encountered including severe forms with intense inflammatory reaction leading to multi-organ failure. Several human factors are involved in the development of invasive infections such as transferrin, factor H or CEACAM1. In this study, we used an experimental meningococcal infection in transgenic mice expressing the human transferrin to show multi-organ infection. Mice were infected by an intraperitoneal injection of bacterial suspension (1.5 × 107 colony-forming unit/mouse) of a bioluminescent serogroup C strain belonging to the clonal complex ST-11. Dynamic imaging and histological analysis were performed. The results showed invasion of tissues by Nm with bacteria observed, outside blood vessels, in the kidneys, the heart and the brain as well as skin involvement. These data further support the systemic aspect of invasive meningococcal disease with involvement of several organs including skin as in humans. Thus, our model can be used to study severe forms of meningococcal invasive infections with multi-organ failure.

Expression of human transferrin can be regulated effectively by rabbit transferrin regulatory elements in transgenic mice

2014 ◽  
Vol 36 (6) ◽  
pp. 1209-1216 ◽  
Author(s):  
Jingbin Yan ◽  
Xiuli Gong ◽  
Shubiao Pan ◽  
Xinbing Guo ◽  
Zhaorui Ren ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Regulatory Elements ◽  
Human Transferrin
Sign in / Sign up

Export Citation Format

Share Document