Baboon Model of Escherichia coli Sepsis: Description of its Four Stages and the Role of Tumor Necrosis Factor, Tissue Factors, and the Protein C System in Septic Shock1

2015 ◽  
pp. 8-14 ◽  
Author(s):  
Fletcher B. Taylor ◽  
A. C. K. Chang ◽  
C. T. Esmon ◽  
L. B. Hinshaw
Keyword(s):  
Escherichia Coli ◽  
Tumor Necrosis Factor ◽  
Protein C ◽  
Tumor Necrosis ◽  
Baboon Model ◽  
Tissue Factors ◽  
Necrosis Factor

scholarly journals Regulation of interleukin 10 release by tumor necrosis factor in humans and chimpanzees.

1994 ◽  
Vol 180 (5) ◽  
pp. 1985-1988 ◽  
Author(s):  
T van der Poll ◽  
J Jansen ◽  
M Levi ◽  
H ten Cate ◽  
J W ten Cate ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Tumor Necrosis Factor ◽  
Intravenous Injection ◽  
Tumor Necrosis ◽  
Feedback Loop ◽  
Interleukin 10 ◽  
Healthy Men ◽  
Bolus Intravenous Injection ◽  
Necrosis Factor

Interleukin 10 (IL-10) has been shown to inhibit endotoxin-induced tumor necrosis factor (TNF) production. To assess the role of TNF in the induction of IL-10 in endotoxemia, four healthy men were studied after a bolus intravenous injection of recombinant human TNF (50 micrograms/m2). In addition, 13 healthy chimpanzees were investigated after a bolus intravenous injection of Escherichia coli endotoxin (4 ng/kg), 6 animals received endotoxin only, 4 animals received a simultaneous intravenous injection of a monoclonal anti-TNF antibody, whereas 3 chimpanzees were treated with an anti-TNF F(ab')2 fragment 30 min after the administration of endotoxin. TNF induced a modest rise in IL-10 concentrations peaking after 45 min (47 +/- 32 pg/ml; p < 0.05). IL-10 peaked 2 h after injection of endotoxin (202 +/- 61 pg/ml; p < 0.005). In both anti-TNF-treated groups, the early endotoxin-induced TNF activity was completely neutralized. Simultaneous anti-TNF treatment attenuated endotoxin-induced IL-10 release (73 +/- 13 pg/ml; p < 0.01 versus endotoxin alone), whereas postponed anti-TNF treatment did not significantly affect this response (p = 0.21). These results indicate that TNF, in part, mediates the induction of IL-10 in endotoxemia, resulting in an autoregulatory feedback loop.

Role of Tumor Necrosis Factor in Toluene Diisocyanate Asthma

2002 ◽  
Vol 27 (4) ◽  
pp. 396-405 ◽  
Author(s):  
Joanna M. Matheson ◽  
Ranulfo Lemus ◽  
Robert W. Lange ◽  
Meryl H. Karol ◽  
Michael I. Luster
Keyword(s):  
Tumor Necrosis Factor ◽  
Tumor Necrosis ◽  
Toluene Diisocyanate ◽  
Necrosis Factor
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