Structural and Functional Aspects of Plateletderived Growth Factor and its Receptors

1990 ◽  
pp. 115-124
Author(s):  
C.-H. Heldin ◽  
B. Westermark
Keyword(s):  
Growth Factor ◽  
Functional Aspects ◽  
Plateletderived Growth Factor

Structural and functional aspects of platelet-derived growth factor and its role in the pathogenesis of glioblastoma

1989 ◽  
Vol 10 (1) ◽  
pp. 27-36 ◽  
Author(s):  
Christer Betsholtz ◽  
Monica Nistér ◽  
Fredrik Rorsman ◽  
Carl-Henrik Heldin ◽  
Bengt Westermark
Keyword(s):  
Growth Factor ◽  
Platelet Derived Growth Factor ◽  
Functional Aspects

scholarly journals A Gain of Function Mutation in the Activation Loop of Plateletderived Growth Factor β-Receptor Deregulates Its Kinase Activity

2004 ◽  
Vol 279 (41) ◽  
pp. 42516-42527 ◽  
Author(s):  
Federica Chiara ◽  
Marie-José Goumans ◽  
Henrik Forsberg ◽  
Aive Ahgrén ◽  
Andrea Rasola ◽  
...  
Keyword(s):  
Growth Factor ◽  
Kinase Activity ◽  
Activation Loop ◽  
Gain Of Function ◽  
Β Receptor ◽  
Plateletderived Growth Factor

Effects of EGF, FGF, and PDGF on Canine Chondrocytes in Three-Dimensional Culture

1997 ◽  
Vol 10 (04) ◽  
pp. 210-213 ◽  
Author(s):  
J. M. Kreeger ◽  
J. T. Payne ◽  
J. L. Tomlinson ◽  
J. L. Cook
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Cell Morphology ◽  
Articular Chondrocytes ◽  
Three Dimensional ◽  
Promote Cell Proliferation ◽  
Cell Counts ◽  
Epidermal Growth ◽  
Matrix Production ◽  
Plateletderived Growth Factor

SummaryThree-dimensional (3-D) culture of chondrocytes has been shown to promote cell proliferation, differentiation, and production of matrix while providing for cell morphology and matrix characteristics that resemble normal articular cartilage (1-3). In a recently published study, enhanced glycosaminoglycan (GAG) production was demonstrated in canine chondrocytes in 3-D culture on cancellous bone substrate (3). The effects of growth factors known to be present in cryopreserved bone were suggested to be responsible. Various growth factors including epidermal growth factor (EGF), fibroblast growth factor (FGF), and plateletderived growth factor (PDGF) have been shown to enhance chondrocyte DNA production, mitotic activity, and matrix production (5-10). The objective of the study reported here was to evaluate the effects of one concentration of EGF, FGF, and PDGF on canine chondrocyte proliferation and production of normal matrix constituents in 3-D culture.Canine articular chondrocytes were cultured in three-dimensional medium for 25 days. EGF, FGF, and PDGF were added to the culture medium. Chondrocytes in 3-D culture maintained viability and differentiation. Cell morphology and matrix production resembled that of intact hyaline cartilage. Significant differences with respect to cell counts, glycosaminoglycan concentration, or collagen type II immuno-reactivity as the result of added growth factors were not found.

scholarly journals Structural and functional aspects of platelet-derived growth factor

1988 ◽  
Vol 57 (6) ◽  
pp. 591-593 ◽  
Author(s):  
C-H Heldin ◽  
A Hammacher ◽  
M Nistér ◽  
B Westermark
Keyword(s):  
Growth Factor ◽  
Platelet Derived Growth Factor ◽  
Functional Aspects
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