Ambulatory Monitoring of Left Ventricular Function: A New Modality for Assessing Silent Myocardial Ischemia

2015 ◽  
pp. 105-116 ◽  
Author(s):  
Barry L. Zaret ◽  
David S. Kayden
Keyword(s):  
Myocardial Ischemia ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Ambulatory Monitoring ◽  
Left Ventricular ◽  
Silent Myocardial Ischemia

scholarly journals Relation between left ventricular function at rest and with exercise and silent myocardial ischemia

1992 ◽  
Vol 19 (5) ◽  
pp. 962-967 ◽  
Author(s):  
Arshed A. Quyyumi ◽  
Julio A. Panza ◽  
Jean G. Diodati ◽  
Vasken Dilsizian ◽  
Timothy S. Callahan ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Left Ventricular ◽  
Silent Myocardial Ischemia

scholarly journals Angiogenic potential of perivascularly delivered aFGF in a porcine model of chronic myocardial ischemia

1998 ◽  
Vol 274 (3) ◽  
pp. H930-H936 ◽  
Author(s):  
John J. Lopez ◽  
Elazer R. Edelman ◽  
Alon Stamler ◽  
Mark G. Hibberd ◽  
Pottumarthi Prasad ◽  
...  
Keyword(s):  
Growth Factors ◽  
Myocardial Ischemia ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Coronary Flow ◽  
Genetically Modified ◽  
Left Ventricular ◽  
Heparin Binding ◽  
Regional Left Ventricular Function ◽  
Chronic Myocardial Ischemia

A number of heparin-binding growth factors, including basic (bFGF) and acidic (aFGF) fibroblast growth factors have been shown to promote angiogenesis in vivo. In this study, we employed a sustained-release polymer extravascular delivery system to evaluate the angiogenic efficacy of a novel form of genetically modified aFGF in the setting of chronic myocardial ischemia. Fifteen Yorkshire pigs subjected to Ameroid occluder placement on the left circumflex (LCX) artery were treated with perivascularly administered aFGF in ethylene vinyl acetate (EVAc) polymer (10 μg, n = 7) or EVAc alone (controls, n = 8). Seven to nine weeks later, after coronary angiography to document Ameroid-induced coronary occlusion, all animals underwent studies of coronary flow and global and regional left ventricular function. Microsphere-determined coronary flow in the Ameroid-compromised territory was significantly increased in aFGF-treated compared with control animals, and this improvement in perfusion was maintained during ventricular pacing. Left ventricular function studies demonstrated improved global and regional function in aFGF-treated animals. We conclude that local perivascular delivery of genetically modified aFGF results in significant improvement in myocardial flow and regional and global left ventricular function.

Demonstration of myocardial ischemia and serial assessment of left ventricular function in cardiac amyloidosis.

1987 ◽  
Vol 51 (2) ◽  
pp. 144-152 ◽  
Author(s):  
TETSU YAMAKADO ◽  
TAKESHI NAKANO ◽  
SATORU KAWAHIRA ◽  
HIROFUMI FUJIOKA ◽  
HIDEO NISHIKAWA ◽  
...  
Keyword(s):  
Myocardial Ischemia ◽  
Left Ventricular Function ◽  
Ventricular Function ◽  
Cardiac Amyloidosis ◽  
Left Ventricular
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