Polyaspartic Acid Protects against Gentamicin-Induced Toxicity: Mechanism of Action1

2015 ◽  
pp. 175-182
Author(s):  
George J. Kaloyanides ◽  
Leslie S. Ramsammy
Keyword(s):  
Polyaspartic Acid ◽  
Toxicity Mechanism

Antimicrobial activity of propolis from Beira Alta (Portugal) and analysis of the toxicity mechanism in fungi

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
RA Marques ◽  
F Baltazar ◽  
A Cunha ◽  
R Oliveira ◽  
CA Aguiar
Keyword(s):  
Antimicrobial Activity ◽  
Toxicity Mechanism

Research on cadmium toxicity mechanism during maize germination

2013 ◽  
Vol 21 (3) ◽  
pp. 356
Author(s):  
HongBao XUE ◽  
Hui ZHANG ◽  
LiLi LIANG ◽  
YanNa JIAO ◽  
Hui LI
Keyword(s):  
Cadmium Toxicity ◽  
Toxicity Mechanism

scholarly journals Effect of polyaspartic acid on pharmacokinetics of gentamicin after single intravenous dose in the dog.

1996 ◽  
Vol 40 (5) ◽  
pp. 1237-1241 ◽  
Author(s):  
T Whittem ◽  
K Parton ◽  
K Turner
Keyword(s):  
Aspartic Acid ◽  
Elimination Rate ◽  
Volume Of Distribution ◽  
Intravenous Dose ◽  
Pharmacokinetic Parameters ◽  
Therapeutic Drug ◽  
Peripheral Compartment ◽  
Single Intravenous Dose ◽  
Polyaspartic Acid ◽  
Peripheral Tissues

The effects of poly-L-aspartic acid on the pharmacokinetics of gentamicin were examined by using a randomized crossover trial design with the dog. When analyzed according to a three-compartment open model, poly-L-aspartic acid reduced some first-order rate equation constants (A3, lambda 1, and lambda 3), the deep peripheral compartment exit microconstant (k31), the elimination rate constant (k(el)), and the area under the concentration-time curve from 0 to 480 h (AUC0-480) (0.21-, 0.60-, 0.26-, 0.27-, 0.72-, and 0.76-fold, respectively; P < 0.05) but increased the volume of distribution at steady state (Vss), the volume of distribution calculated by the area method (V(area)), the apparent volume of the peripheral compartment (Vp), and all mean time parameters. These results suggested that poly-L-aspartic acid increased the distribution of gentamicin to or binding within the deep peripheral compartment and that poly-L-aspartic acid may have delayed gentamicin transit through the peripheral tissues. In contrast, poly-L-aspartic acid did not alter pharmacokinetic parameters relevant to the central or shallow peripheral compartments to a clinically significant extent. Although gentamicin's pharmacokinetic parameters of relevance to therapeutic drug monitoring were not directly altered, this study has provided pharmacokinetic evidence that poly-L-aspartic acid alters the peripheral distribution of gentamicin. This pharmacokinetic interaction occurred after a single intravenous dose of each drug. Therefore, this interaction should be investigated further, before polyaspartic acid can be considered for use as a clinical nephroprotectant.

scholarly journals Incorporation of alternative amino acids into cyanophycin by different cyanophycin synthetases heterologously expressed in Corynebacterium glutamicum

AMB Express ◽  
2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Ramona Wördemann ◽  
Lars Wiefel ◽  
Volker F. Wendisch ◽  
Alexander Steinbüchel
Keyword(s):  
Amino Acids ◽  
Dry Weight ◽  
Growth Conditions ◽  
Amino Acid Biosynthesis ◽  
Water Soluble ◽  
Lysine Content ◽  
Polyaspartic Acid ◽  
Acid Biosynthesis ◽  
Cyanophycin Synthetase ◽  
Potential Precursor

AbstractCyanophycin (multi-l-arginyl-poly-l-aspartic acid; also known as cyanophycin grana peptide [CGP]) is a biopolymer that could be used in various fields, for example, as a potential precursor for the synthesis of polyaspartic acid or for the production of CGP-derived dipeptides. To extend the applications of this polymer, it is therefore of interest to synthesize CGP with different compositions. A recent re-evaluation of the CGP synthesis in C. glutamicum has shown that C. glutamicum is a potentially interesting microorganism for CGP synthesis with a high content of alternative amino acids. This study shows that the amount of alternative amino acids can be increased by using mutants of C. glutamicum with altered amino acid biosynthesis. With the DM1729 mutant, the lysine content in the polymer could be increased up to 33.5 mol%. Furthermore, an ornithine content of up to 12.6 mol% was achieved with ORN2(Pgdh4). How much water-soluble or insoluble CGP is synthesized is strongly related to the used cyanophycin synthetase. CphADh synthesizes soluble CGP exclusively. However, soluble CGP could also be isolated from cells expressing CphA6308Δ1 or CphA6308Δ1_C595S in addition to insoluble CGP in all examined strains. The point mutation in CphA6308Δ1_C595S partially resulted in a higher lysine content. In addition, the CGP content could be increased to 36% of the cell dry weight under optimizing growth conditions in C. glutamicum ATCC13032. All known alternative major amino acids for CGP synthesis (lysine, ornithine, citrulline, and glutamic acid) could be incorporated into CGP in C. glutamicum.

PEROXIDASE-CATALYZED CROSSlINKING OF FUNCTIONALIZED POLYASPARTIC ACID POLYMERS

2002 ◽  
Vol 39 (10) ◽  
pp. 1151-1181 ◽  
Author(s):  
Susan Sofia ◽  
Amarjit Singh ◽  
David Kaplan
Keyword(s):  
Polyaspartic Acid

scholarly journals Insights into the toxicity mechanism of and cell response to the herbicide 2,4-D in plants

2012 ◽  
Vol 7 (3) ◽  
pp. 425-427 ◽  
Author(s):  
Diana M. Pazmiño ◽  
María C. Romero-Puertas ◽  
Luisa M. Sandalio
Keyword(s):  
Cell Response ◽  
Toxicity Mechanism

A novel polyaspartic acid derivative with multifunctional groups for scale inhibition application

2017 ◽  
Vol 39 (7) ◽  
pp. 843-850 ◽  
Author(s):  
Ying Zhang ◽  
Hongquan Yin ◽  
Qingshan Zhang ◽  
Yunzheng Li ◽  
Pengjun Yao ◽  
...  
Keyword(s):  
Acid Derivative ◽  
Polyaspartic Acid ◽  
Scale Inhibition

scholarly journals Pharmacologic limits of the protective effect of polyaspartic acid on experimental gentamicin nephrotoxicity.

1993 ◽  
Vol 37 (2) ◽  
pp. 347-348 ◽  
Author(s):  
S K Swan ◽  
D N Gilbert ◽  
S J Kohlhepp ◽  
P W Kohnen ◽  
W M Bennett
Keyword(s):  
Protective Effect ◽  
Polyaspartic Acid

Ammonia toxicity mechanism in fish: Studies on rainbow trout (Salmo gairdneri Rich.)

1981 ◽  
Vol 5 (3) ◽  
pp. 316-328 ◽  
Author(s):  
A. Arillo ◽  
C. Margiocco ◽  
F. Melodia ◽  
P. Mensi ◽  
G. Schenone
Keyword(s):  
Rainbow Trout ◽  
Ammonia Toxicity ◽  
Salmo Gairdneri ◽  
Toxicity Mechanism

Polyaspartic acid alleviates heavy metal toxicity in zebrafish (Danio rerio)

2017 ◽  
Vol 33 (7) ◽  
pp. 684-693 ◽  
Author(s):  
Tuo Liu ◽  
Ruilin Wang ◽  
Hui Cao ◽  
Aijun Lin
Keyword(s):  
Heavy Metal ◽  
Danio Rerio ◽  
Metal Toxicity ◽  
Heavy Metal Toxicity ◽  
Polyaspartic Acid
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