Studies on Insulin Receptors of Brush-Border Membranes Isolated from Human Kidney Proximal Tubule

2015 ◽  
pp. 67-74
Author(s):  
J. E. Scherberich ◽  
S. Zeuzem ◽  
G. Wolf ◽  
W. Schoeppe
Keyword(s):  
Proximal Tubule ◽  
Brush Border ◽  
Insulin Receptors ◽  
Human Kidney ◽  
Kidney Proximal Tubule ◽  
Brush Border Membranes

scholarly journals A Multicompartment Human Kidney Proximal Tubule-on-a-Chip Replicates Cell Polarization–Dependent Cisplatin Toxicity

2020 ◽  
Vol 48 (12) ◽  
pp. 1303-1311
Author(s):  
Tom T.G. Nieskens ◽  
Mikael Persson ◽  
Edward J. Kelly ◽  
Anna-Karin Sjögren
Keyword(s):  
Proximal Tubule ◽  
Human Kidney ◽  
Cell Polarization ◽  
Kidney Proximal Tubule

scholarly journals Flow stimulates drug transport in a human kidney proximal tubule-on-a-chip independent of primary cilia

2020 ◽  
Vol 1864 (1) ◽  
pp. 129433 ◽  
Author(s):  
Jelle Vriend ◽  
Janny G.P. Peters ◽  
Tom T.G. Nieskens ◽  
Renata Škovroňová ◽  
Nina Blaimschein ◽  
...  
Keyword(s):  
Proximal Tubule ◽  
Drug Transport ◽  
Primary Cilia ◽  
Human Kidney ◽  
Kidney Proximal Tubule

scholarly journals Predicting tubular reabsorption with a human kidney proximal tubule tissue-on-a-chip and physiologically-based modeling

2020 ◽  
Vol 63 ◽  
pp. 104752 ◽  
Author(s):  
Courtney Sakolish ◽  
Zunwei Chen ◽  
Chimeddulam Dalaijamts ◽  
Kusumica Mitra ◽  
Yina Liu ◽  
...  
Keyword(s):  
Proximal Tubule ◽  
Human Kidney ◽  
Tubular Reabsorption ◽  
Kidney Proximal Tubule ◽  
Physiologically Based

Hormonal regulation of rat renal proximal tubule brush-border membrane ionic permeability

1992 ◽  
Vol 263 (1) ◽  
pp. F144-F151 ◽  
Author(s):  
M. S. Lipkowitz ◽  
R. D. London ◽  
J. C. Beck ◽  
R. G. Abramson
Keyword(s):  
Parathyroid Hormone ◽  
Proximal Tubule ◽  
Brush Border ◽  
Renal Proximal Tubule ◽  
Ionic Permeability ◽  
Brush Border Membranes ◽  
Rat Renal Proximal Tubule ◽  
Selective Increase ◽  
Gi Proteins ◽  
Cl Permeability

The effects on ionic permeability of toxins and hormones that activate or deactivate the guanine nucleotide regulatory (G) proteins that govern adenylate cyclase activity were examined in rat renal proximal tubule cell brush-border membranes. These studies demonstrate that activation of stimulatory G (Gs) proteins by cholera toxin or parathyroid hormone and deactivation of inhibitory (G (Gi) proteins by pertussis toxin result in a selective increase in Cl- permeability relative to that of K+ as determined with the potential-sensitive fluorescent probe 3,3'-dipropylthiadicarbocyanine iodide [diS-C3-(5)]. In contrast, activation of Gi by angiotensin II significantly decreases relative Cl- permeability. The selective increase in relative Cl- permeability induced by parathyroid hormone results in an inside-negative potential in membrane vesicles exposed to an inward NaCl gradient that is of sufficient magnitude to stimulate electrogenic, Na(+)-dependent glucose transport. These data suggest that the relative ionic permeabilities of brush-border membranes are tonically regulated by the opposing effects of hormones that act via Gs or Gi proteins. Changes in membrane potential resulting from this regulation may play an important role in modifying transport in the proximal tubule.

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