Renal Metabolism of C Peptide in Patients with Early Insulin-Dependent Diabetes mellitus

2015 ◽  
pp. 145-147
Author(s):  
I. Zavaroni ◽  
C. Robaudo ◽  
L. Gnudi ◽  
S. Saffioti ◽  
R. Lugari ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Renal Metabolism ◽  
C Peptide ◽  
Insulin Dependent

Renal Metabolism of C-Peptide in Patients with Early Insulin-Dependent Diabetes mellitus

Nephron ◽  
1996 ◽  
Vol 72 (3) ◽  
pp. 395-401 ◽  
Author(s):  
Cristina Robaudo ◽  
Ivana Zavaroni ◽  
Giacomo Garibotto ◽  
Giacomo Deferrari
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
Renal Metabolism ◽  
C Peptide ◽  
Insulin Dependent

scholarly journals High 24-Hour Urinary C-Peptide Excretion in Non-Insulin Dependent Diabetes Mellitus

1986 ◽  
Vol 1 (2) ◽  
pp. 172-178
Author(s):  
Young Hwan Chung ◽  
Kyong Soo Park ◽  
Ki Up Lee ◽  
Seong Yeon Kim ◽  
Hong Kyu Lee ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
C Peptide ◽  
Insulin Dependent

scholarly journals Efficacy and Safety of Allogenic Canine Adipose Tissue-derived Mesenchymal Stem Cell Therapy for Insulin Dependent Diabetes Mellitus in Dogs: A pilot study

2019 ◽  
Author(s):  
Sung-Yong Rhew ◽  
Woo-Jin Song ◽  
Qiang Li ◽  
Ju-Hyun An ◽  
Hyung-Kyu Chae ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Adipose Tissue ◽  
Stem Cell ◽  
Pilot Study ◽  
Diabetic Complications ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
C Peptide ◽  
Insulin Dependent

Abstract Background Since mesenchymal stem cells (MSCs) possess regenerative and immunomodulatory properties, and are capable of controlling the immune dysregulation that leads to β-cell destruction, stem cell transplantation could be used in the management of insulin-dependent diabetes mellitus (IDDM). In this pilot study, we assessed whether canine adipose tissue-derived MSC (cAT-MSC) therapy could be an option for treatment of canine diabetes mellitus. Results With the written informed consent of the owners, allogenic cAT-MSCs were infused intravenously in IDDM dogs. C-peptide was elevated by about 5–15% in 3 of 4 cases, and hyperlipidemia was resolved in 2 of 4 cases. Additionally, fructosamine and Hb/A1c levels were improved in 2 of 4 cases. Conclusions Considering that C-peptide secretion capacity and lipid metabolism are related to diabetic complications, these results suggest that cAT-MSC therapy in diabetic dogs might help to improve the insulin secretory capacity of dogs with IDDM and prevent diabetic complications.

Recovery from Decompensated Non-insulin-dependent Diabetes Mellitus: Studies of C-Peptide Secretion

Diabetes Care ◽  
1981 ◽  
Vol 4 (3) ◽  
pp. 354-359 ◽  
Author(s):  
M. Rendell ◽  
J. Zarriello ◽  
H. M. Drew ◽  
B. Dranbauer ◽  
G. Wilson ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
C Peptide ◽  
Insulin Dependent ◽  
Peptide Secretion

Mode of action of chloroquine in patients with non-insulin-dependent diabetes mellitus

1991 ◽  
Vol 260 (6) ◽  
pp. E897-E904 ◽  
Author(s):  
J. K. Powrie ◽  
G. D. Smith ◽  
F. Shojaee-Moradie ◽  
P. H. Sonksen ◽  
R. H. Jones
Keyword(s):  
Diabetes Mellitus ◽  
Feedback Inhibition ◽  
Controlled Trial ◽  
Insulin Dependent Diabetes Mellitus ◽  
Insulin Dependent Diabetes ◽  
Dependent Diabetes Mellitus ◽  
High Dose ◽  
Metabolic Clearance ◽  
C Peptide ◽  
Insulin Dependent

Clinical studies have demonstrated that chloroquine and hydroxychloroquine improve glucose metabolism in patients with insulin-resistant diabetes mellitus. The mechanism of action has not been determined. We undertook a randomized double-blind placebo-controlled trial of 3 days of oral chloroquine phosphate, 250 mg four times daily, in 20 patients with non-insulin-dependent diabetes mellitus controlled by diet. Rates of glucose appearance (Ra) and disappearance (Rd) were evaluated by infusion of stable isotopically labeled D-glucose ([6,6-2H2]glucose) during hyperinsulinemic euglycemic clamps before and after treatment with chloroquine or placebo. Chloroquine significantly improved fasting plasma glucose from 199.8 +/- 8.6 to 165.6 +/- 7.6 mg/dl (P less than 0.01). Total exogenous glucose infusion required to maintain euglycemia significantly increased (1,792.6-2,040.1 mg.kg-1.330 min-1, P less than 0.05) due to an increase in Rd (2,348.0-2,618.9 mg.kg-1.330 min-1, P less than 0.01) without change in Ra. Metabolic clearance rate of insulin decreased by 39% from 14.4 +/- 1.3 to 11.0 +/- 0.6 ml.kg-1.min-1 (P less than 0.01) at plasma insulin levels of 150-200 mU/l but not at levels of 2,000-3,000 mU/l. In addition, chloroquine increased fasting C-peptide secretion by 17% and reduced feedback inhibition of C-peptide by 9.1 and 10.6% during low- and high-dose insulin infusions, respectively.

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