Chronic Hypoxia in the Rat: Changed Pulmonary Haemodynamics Caused by Inflation and Deflation and during Vasoconstriction by Hypoxia and Almitrine

This study addresses respiratory and motor impairments in an experimental reserpine-induced model of parkinsonism in rats. The role of chronic hypoxia due to diminished ventilation in the development and course of neurodegeneration is addressed. An attempt was made to distinguish between central and peripheral dopamine pathways in the mechanisms of neurodegeneration. A dissociation of putative mechanisms of respiratory and motor impairments is tackled as well. Although this purely experimental study cannot be directly extrapolated to human pathophysiology, the corollaries have been drawn concerning the potential repercussions of the respiratory and motor impairments for the physiotherapeutic procedures in the management of chronic neurodegeneration.

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Chronic Hypoxia as a Potential Factor in Human Life-threatening Diseases

International Journal of Pharmaceutical Sciences and Nanotechnology ◽

10.37285/ijpsn.2017.10.4.1 ◽

2017 ◽

Vol 10 (4) ◽

pp. 3759-3762

Author(s):

Sandhya MNVS ◽

Vanitha K ◽

Ramesh A

Keyword(s):

Chronic Hypoxia ◽

Atmospheric Oxygen ◽

Human Life ◽

The Body ◽

Cellular Damage ◽

Otto Warburg ◽

Regular Treatment ◽

Breathing Exercises ◽

Hypoxic Conditions ◽

Cancerous Cell

The review article focuses on the importance of adequate oxygen levels in the body as cure and therapy for many ailments. It is known that hypoxia is the cause for cellular damage and if it can be applied to major patho-physiology’s, it can be observed that slow and chronic hypoxic conditions are the cause for most of the diseases. On the contrary, providing each cell of the body with proper oxygen may be helpful in maintaining the immunity of the body and therefore treating many disease conditions. This theory, if tested may show positive results in heart related diseases, neuronal disorders, stresses, digestive disorders and the unresolved cancer too. Slow decrease in the levels of atmospheric oxygen could be a reason to induce chronic hypoxia. According to Dr. Otto Warburg, a Noble laurate, a normal cell when deprived of oxygen, may get converted to a cancerous cell, whereas a cancerous cell cannot survive in aerobic conditions. If this part of his research be concentrated on, there could be fruitful results in the treatment of cancer. To maintain adequate levels of oxygen in the body, simple yogic breathing practices are helpful. And to maintain the adequate atmospheric oxygen, trees and plants which cleanse the atmospheric air are useful. Clinical surveys on volunteers who have been practicing regular breathing exercises can prove the fact that proper and concentrated respiration could prevent many diseases. Thus, supplementing breathing exercises along with the regular treatment for cancer patients could be helpful in alleviating cancer and other diseases.

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PARP Inhibitor Protects Against Chronic Hypoxia/Reoxygenation-Induced Retinal Injury by Regulation of MAPKs, HIF1α, Nrf2, and NFκB

Investigative Opthalmology & Visual Science ◽

10.1167/iovs.18-25936 ◽

2019 ◽

Vol 60 (5) ◽

pp. 1478 ◽

Cited By ~ 12

Author(s):

Krisztina Kovacs ◽

Alexandra Vaczy ◽

Katalin Fekete ◽

Petra Kovari ◽

Tamas Atlasz ◽

...

Keyword(s):

Chronic Hypoxia ◽

Parp Inhibitor ◽

Retinal Injury ◽

Hypoxia Reoxygenation

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Effect of HIF1α on the TRPC6 channel of glomerular podocytes under chronic hypoxia

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2020.12.088 ◽

2021 ◽

Vol 541 ◽

pp. 1-7

Author(s):

Guangrong Hu ◽

Yonghan He ◽

Yaozong Li ◽

Xiao Hu ◽

Sida Liu ◽

...

Keyword(s):

Chronic Hypoxia ◽

Trpc6 Channel

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