Methodology of Gastric pH-Metry

2015 ◽  
pp. 19-31 ◽  
Author(s):  
F. Pace ◽  
G. Bianchi Porro
Keyword(s):  
Gastric Ph ◽  
Ph Metry

Combined esophageal and gastric ph-metry in healthy volunteers influence of cable through les and effect of misoprostol

1989 ◽  
Vol 34 (1) ◽  
pp. 79-82 ◽  
Author(s):  
C. Emde ◽  
T. Cilluffo ◽  
P. Bauerfeind ◽  
A. L. Blum
Keyword(s):  
Healthy Volunteers ◽  
Gastric Ph ◽  
Ph Metry

24 hours gastric pH metry in patients with distal partial gastrectomy

2004 ◽  
Vol 42 (05) ◽  
Author(s):  
L Szalai ◽  
Z Gurzó ◽  
I Fazekas ◽  
G Gyimesi ◽  
S Ilyés ◽  
...  
Keyword(s):  
Partial Gastrectomy ◽  
Gastric Ph ◽  
Ph Metry ◽  
Distal Partial Gastrectomy

The Diagnostic Yield of Gastric pH-Metry During Ambulatory Gastro-Oesophageal Reflux Monitoring

2017 ◽  
Vol 152 (5) ◽  
pp. S657
Author(s):  
Joanne L. Ooi ◽  
Philip J. Woodland ◽  
Esteban Glasinovic ◽  
Justin Koh ◽  
Kornilia Nikaki ◽  
...  
Keyword(s):  
Diagnostic Yield ◽  
Gastric Ph ◽  
Oesophageal Reflux ◽  
Ph Metry

The role of pH-metry in the diagnosis of vaginal infections

GYNECOLOGY ◽  
2014 ◽  
Vol 16 (2) ◽  
pp. 9-13
Author(s):  
E.F. Kira ◽  
◽  
K.E. Semenova ◽  
A.M. Markarian ◽  
◽  
...  
Keyword(s):  
Vaginal Infections ◽  
Ph Metry

scholarly journals Amorphous Solid Dispersion Tablets Overcome Acalabrutinib pH Effect in Dogs

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 557
Author(s):  
Deanna M. Mudie ◽  
Aaron M. Stewart ◽  
Jesus A. Rosales ◽  
Nishant Biswas ◽  
Molly S. Adam ◽  
...  
Keyword(s):  
Solid Dispersion ◽  
Drug Exposure ◽  
Ph Effect ◽  
Hydroxypropyl Methylcellulose ◽  
Amorphous Solid ◽  
Gastric Ph ◽  
Patient Treatment ◽  
Oral Exposure ◽  
Amorphous Solid Dispersion ◽  
Plasma Drug

Calquence® (crystalline acalabrutinib), a commercially marketed tyrosine kinase inhibitor (TKI), exhibits significantly reduced oral exposure when taken with acid-reducing agents (ARAs) due to the low solubility of the weakly basic drug at elevated gastric pH. These drug–drug interactions (DDIs) negatively impact patient treatment and quality of life due to the strict dosing regimens required. In this study, reduced plasma drug exposure at high gastric pH was overcome using a spray-dried amorphous solid dispersion (ASD) comprising 50% acalabrutinib and 50% hydroxypropyl methylcellulose acetate succinate (HPMCAS, H grade) formulated as an immediate-release (IR) tablet. ASD tablets achieved similar area under the plasma drug concentration–time curve (AUC) at low and high gastric pH and outperformed Calquence capsules 2.4-fold at high gastric pH in beagle dogs. In vitro multicompartment dissolution testing conducted a priori to the in vivo study successfully predicted the improved formulation performance. In addition, ASD tablets were 60% smaller than Calquence capsules and demonstrated good laboratory-scale manufacturability, physical stability, and chemical stability. ASD dosage forms are attractive for improving patient compliance and the efficacy of acalabrutinib and other weakly basic drugs that have pH-dependent absorption.

P.1.170: BODY MASS INDEX AND GASTROESOPHAGEAL REFLUX ASSESSED BY PH-METRY

2011 ◽  
Vol 43 ◽  
pp. S204
Author(s):  
V. D'Onofrio ◽  
M. Bruno ◽  
N. Giardullo ◽  
R. Melina ◽  
R. D'Onofrio ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Gastroesophageal Reflux ◽  
Body Mass ◽  
Ph Metry
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