HIV Infection of Mononuclear Phagocytes: Role of Antibody-Mediated Virus Binding to Fc-? Receptors1

2015 ◽  
pp. 177-183
Author(s):  
J. C. Gluckman ◽  
T. Jouault ◽  
F. Chapuis ◽  
R. Olivier ◽  
E. Bahraoui ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Mononuclear Phagocytes ◽  
Virus Binding

Health and social problems associated with HIV infection and AIDS in the professional activity of specialists with secondary medical education

2020 ◽  
pp. 5-13
Author(s):  
L. Guseva
Keyword(s):  
Medical Education ◽  
Hiv Infection ◽  
Clinical Signs ◽  
Modern Society ◽  
Progressive Increase ◽  
Professional Activity ◽  
Infected People ◽  
Immunodeficiency Virus ◽  
Epidemiological Characteristics

The article considers urgent problem of modern society – progressive increase in the number of people infected with the human immunodeficiency virus (HIV). Epidemiological characteristics of the pathogen are given, clinical signs of the disease and a modern strategy aimed at reducing the number of infected people are presented. The role of specialists with secondary medical education in the implementation of the Strategy aimed at combating the spread of HIV infection epidemic in the Russian Federation is emphasized.

scholarly journals Deconvolution of monocyte responses in inflammatory bowel disease reveals an IL-1 cytokine network that regulates IL-23 in genetic and acquired IL-10 resistance

Gut ◽  
2020 ◽  
pp. gutjnl-2020-321731
Author(s):  
Dominik Aschenbrenner ◽  
Maria Quaranta ◽  
Soumya Banerjee ◽  
Nicholas Ilott ◽  
Joanneke Jansen ◽  
...  
Keyword(s):  
Mononuclear Cells ◽  
Personalised Medicine ◽  
Mononuclear Phagocytes ◽  
Cytokine Network ◽  
Peripheral Blood Mononuclear ◽  
Transcriptional Signature ◽  
Inflammatory Monocytes ◽  
Transcriptomic Signature ◽  
Inflammatory Bowel

ObjectiveDysregulated immune responses are the cause of IBDs. Studies in mice and humans suggest a central role of interleukin (IL)-23-producing mononuclear phagocytes in disease pathogenesis. Mechanistic insights into the regulation of IL-23 are prerequisite for selective IL-23 targeting therapies as part of personalised medicine.DesignWe performed transcriptomic analysis to investigate IL-23 expression in human mononuclear phagocytes and peripheral blood mononuclear cells. We investigated the regulation of IL-23 expression and used single-cell RNA sequencing to derive a transcriptomic signature of hyperinflammatory monocytes. Using gene network correlation analysis, we deconvolved this signature into components associated with homeostasis and inflammation in patient biopsy samples.ResultsWe characterised monocyte subsets of healthy individuals and patients with IBD that express IL-23. We identified autosensing and paracrine sensing of IL-1α/IL-1β and IL-10 as key cytokines that control IL-23-producing monocytes. Whereas Mendelian genetic defects in IL-10 receptor signalling induced IL-23 secretion after lipopolysaccharide stimulation, whole bacteria exposure induced IL-23 production in controls via acquired IL-10 signalling resistance. We found a transcriptional signature of IL-23-producing inflammatory monocytes that predicted both disease and resistance to antitumour necrosis factor (TNF) therapy and differentiated that from an IL-23-associated lymphocyte differentiation signature that was present in homeostasis and in disease.ConclusionOur work identifies IL-10 and IL-1 as critical regulators of monocyte IL-23 production. We differentiate homeostatic IL-23 production from hyperinflammation-associated IL-23 production in patients with severe ulcerating active Crohn’s disease and anti-TNF treatment non-responsiveness. Altogether, we identify subgroups of patients with IBD that might benefit from IL-23p19 and/or IL-1α/IL-1β-targeting therapies upstream of IL-23.

scholarly journals Role of PD-1 co-inhibitory pathway in HIV infection and potential therapeutic options

Retrovirology ◽  
2015 ◽  
Vol 12 (1) ◽  
Author(s):  
Vijayakumar Velu ◽  
Ravi Dyavar Shetty ◽  
Marie Larsson ◽  
Esaki M Shankar
Keyword(s):  
Hiv Infection ◽  
Therapeutic Options ◽  
Inhibitory Pathway

scholarly journals ROLE OF AYURVEDIC DRUGS IN TREATMENT OF HIV INFECTION

1998 ◽  
Vol 54 (4) ◽  
pp. 374
Author(s):  
SK SAYAL ◽  
S BANERJEE ◽  
AL DAS ◽  
CM GUPTA ◽  
VV DOIPHADE ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Ayurvedic Drugs

The role of mononuclear phagocytes in HTLV-III/LAV infection

Science ◽  
1986 ◽  
Vol 233 (4760) ◽  
pp. 215-219 ◽  
Author(s):  
S Gartner ◽  
P Markovits ◽  
D. Markovitz ◽  
M. Kaplan ◽  
R. Gallo ◽  
...  
Keyword(s):  
Mononuclear Phagocytes

The Role of the Framingham Risk Score to Predict the Presence of Subclinical Coronary Atherosclerosis in Patients with HIV Infection

2009 ◽  
Vol 52 (2) ◽  
pp. 303-304 ◽  
Author(s):  
Rosario Rossi ◽  
Annachiara Nuzzo ◽  
Giovanni Guaraldi ◽  
Gabriella Orlando ◽  
Nicola Squillace ◽  
...  
Keyword(s):  
Hiv Infection ◽  
Risk Score ◽  
Coronary Atherosclerosis ◽  
Framingham Risk Score ◽  
Framingham Risk
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