The Measurement of Intrarenal Plasma Flow Distribution in Essential Hypertension

2015 ◽  
pp. 186-189
Author(s):  
K. E. Britton ◽  
A. M. Al-Nahhas ◽  
C. C. Nimmon ◽  
M. J. Carroll ◽  
F. Fiore ◽  
...  
Keyword(s):  
Essential Hypertension ◽  
Plasma Flow ◽  
Flow Distribution

Haemodynamic and Endocrine Responses of the Kidney to Frusemide in Mild Essential Hypertension

1985 ◽  
Vol 68 (2) ◽  
pp. 159-164 ◽  
Author(s):  
I. G. Mackay ◽  
K. Nath ◽  
A. D. Cumming ◽  
A. L. Muir ◽  
M. L. Watson
Keyword(s):  
Glomerular Filtration Rate ◽  
Essential Hypertension ◽  
Plasma Renin Activity ◽  
Plasma Flow ◽  
Filtration Rate ◽  
Renal Plasma Flow ◽  
Plasma Renin ◽  
Normal Subjects ◽  
Underlying Factor ◽  
Induced Changes

1. Prostaglandin-dependent, frusemide-induced changes in renal plasma flow, glomerular filtration rate and plasma renin activity were measured in 14 patients with mild essential hypertension. 2. The renal haemodynamic responses to frusemide were the same as in 10 normal subjects. 3. Frusemide-induced changes in urinary PGE and kallikrein excretion were also the same as in normal subjects. 4. Impaired renal release of vasodilator prostaglandins in essential hypertension is likely to be secondary to the hypertension rather than an underlying factor in its development.

Altered renal response to enhanced endogenous 5-hydroxytryptamine after tryptophan administration in essential hypertension

1992 ◽  
Vol 82 (5) ◽  
pp. 551-557 ◽  
Author(s):  
Fumihiro Tomoda ◽  
Masanobu Takata ◽  
Shinya Oh-Hashi ◽  
Hitoshi Ueno ◽  
Kotaro Yasumoto ◽  
...  
Keyword(s):  
Glomerular Filtration Rate ◽  
Essential Hypertension ◽  
Urinary Excretion ◽  
Glomerular Filtration ◽  
Plasma Flow ◽  
Filtration Rate ◽  
Renal Plasma Flow ◽  
Renal Response ◽  
Hypertensive Group ◽  
Normotensive Subjects

1. To examine the pathophysiological significance of 5-hydroxytryptamine (serotonin) in essential hypertension, we compared the renal response to intrarenally formed 5-hydroxytryptamine by oral dosing with its precursor, L-tryptophan (2 g), in nine patients with essential hypertension and in six subjects with normotension. 2. Before tryptophan administration, urinary excretion of 5-hydroxytryptamine was significantly higher in the hypertensive group than in the normotensive group (66 ± 8 versus 36 ± 6 ng/min, P < 0.05), whereas renal plasma flow and glomerular filtration rate did not differ between the two groups. After dosing with tryptophan, urinary excretion of 5-hydroxytryptamine significantly increased to the same plateau level in both groups (366 ± 55 ng/min in the hypertensive group and 365 ± 64 ng/min in the normotensive group). Significant and equivalent decreases in renal plasma flow were observed in the early phase after tryptophan administration in both groups (−8.5 ± 3.4% in the hypertensive group and −8.2 ± 1.7% in the normotensive group). Thereafter, renal plasma flow increased to above the baseline value in normotensive subjects, whereas this late vasodilatation was absent in the hypertensive group. Glomerular filtration rate significantly decreased at the time of the fall in renal plasma flow in the normotensive group (106.8 ± 7.8 to 92.7 ± 8.5 ml min−1 1.73 m−2, P < 0.05), whereas it remained unchanged in the hypertensive group (108.2 ± 6.2 to 110.4 ± 6.3 ml min−1 1.73 m−2, not significant). Consequently, the filtration fraction did not change in normotensive subjects (0.21 ± 0.01 versus 0.19 ± 0.01, not significant), but it increased significantly in the hypertensive group (0.22 ± 0.01 versus 0.26 ± 0.02, P < 0.05). A similar sustained antidiuresis was also observed after tryptophan administration in both groups. In addition, the above-described renal functional changes were not accompanied by any significant changes in systemic blood pressure, the renin-angiotensin-aldosterone system, adrenergic activity or plasma 5-hydroxytryptamine concentration in either group. 3. Our data show that in essential hypertension there is a baseline overproduction of renal 5-hydroxytryptamine, which may contribute to a reduction in renal excretory capability. The altered renal response to tryptophan found in essential hypertension may be partly related to the exaggerated efferent arteriolar constriction induced by endogenously formed 5-hydroxytryptamine.

Plasma Prostaglandins PGE2 and PGF2α, Total Effective Vascular Compliance and Renal Plasma Flow in Essential Hypertension

Nephron ◽  
1982 ◽  
Vol 32 (2) ◽  
pp. 118-124 ◽  
Author(s):  
G.M. London ◽  
A. Hornych ◽  
M.E. Safar ◽  
J.A. Levenson ◽  
A.C. Simon
Keyword(s):  
Essential Hypertension ◽  
Plasma Flow ◽  
Renal Plasma Flow ◽  
Vascular Compliance ◽  
Effective Vascular Compliance

Intrarenal plasma flow distribution during micropuncture in the dog

1972 ◽  
Vol 222 (3) ◽  
pp. 649-652 ◽  
Author(s):  
JD Wallin ◽  
AH Israelit ◽  
Rector FC ◽  
DW Seldin
Keyword(s):  
Plasma Flow ◽  
Flow Distribution
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