Renal Tubular Reabsorption of Calcium in Primary Hyperparathyroidism

2015 ◽  
pp. 63-67
Author(s):  
J. H. Kristiansen ◽  
J. Br�chner-Mortensen ◽  
K. O. Pedersen ◽  
S. Jensen ◽  
T. Glud
Keyword(s):  
Primary Hyperparathyroidism ◽  
Tubular Reabsorption ◽  
Renal Tubular Reabsorption ◽  
Renal Tubular

Renal tubular reabsorption of calcium and sodium in primary hyperparathyroidism

1990 ◽  
Vol 123 (2) ◽  
pp. 194-202 ◽  
Author(s):  
Jan H. Kristiansen ◽  
Jens Brøchner-Mortensen ◽  
Kaj O. Pedersen ◽  
Søren Jensen ◽  
Torben Glud
Keyword(s):  
Primary Hyperparathyroidism ◽  
Proximal Tubule ◽  
Distal Tubule ◽  
Tubular Reabsorption ◽  
Positive Linear Correlation ◽  
Calcium Reabsorption ◽  
Renal Tubular Reabsorption ◽  
The Absolute ◽  
Renal Tubular ◽  
Reabsorption Rate

Abstract. Nine patients with primary hyperparathyroidism were studied to investigate the renal tubular reabsorption of calcium and sodium. Fasting serum and urine samples were analysed, and the glomerular filtration rate and the renal plasma clearance of lithium were determined simultaneously. Comparison was made with 9 ageand sex-matched normocalcemic controls. In the proximal tubule, there was a significantly higher absolute reabsorption of calcium in patients than in controls, whereas the fractional reabsorption rate of calcium did not differ between the two groups. In the distal tubule, the absolute calcium reabsorption rate was significantly higher in the patients, whereas the fractional reabsorption rate of calcium was significantly lower than in controls. In the patient group there was a significantly positive linear correlation between the increased tubular capacity for calsium reabsorption and the absolute proximal calcium reabsorption rate, but not between the increased capacity and the absolute distal calcium reabsorption rate. No significant differences were found in the renal tubular handling of sodium between patients and controls. Our results suggest that the increased capacity for tubular calcium reabsorption in primary hyperparathyroidism mainly is localized in the proximal tubule, and that the renal tubular handling of calcium and sodium in this disease differs from that in familial hypocalciuric hypercalcemia.

scholarly journals Early post-transplantation hypophosphatemia is associated with elevated FGF-23 levels

2011 ◽  
Vol 164 (5) ◽  
pp. 839-847 ◽  
Author(s):  
Andrea Trombetti ◽  
Laura Richert ◽  
Karine Hadaya ◽  
Jean-Daniel Graf ◽  
François R Herrmann ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Tubular Reabsorption ◽  
Phosphate Metabolism ◽  
Multivariate Models ◽  
Intact Pth ◽  
Post Transplantation ◽  
Estimated Gfr ◽  
Renal Tubular Reabsorption ◽  
Renal Tubular ◽  
Fgf 23

BackgroundWe examined the hypothesis that high FGF-23 levels early after transplantation contribute to the onset of hypophosphatemia, independently of parathyroid hormone (PTH) and other factors regulating phosphate metabolism.MethodsWe measured serum phosphate levels (sPi), renal tubular reabsorption of Pi (TmPi/GFR), estimated GFR (eGFR), intact PTH (iPTH), calcitriol, intact (int) and C-terminal (Cter) FGF-23, dietary Pi intake and cumulative doses of glucocorticoids in 69 patients 12 days (95% confidence interval, 10–13) after renal transplantation.ResultsHypophosphatemia was observed in 43 (62%) of the patients 12 days after transplantation. Compared with non-hypophosphatemic subjects, their post-transplantation levels of intact and CterFGF-23 were higher (195 (108–288) vs 48 (40–64) ng/l, P<0.002 for intFGF-23; 205 (116–384) vs 81 (55–124) U/ml, P<0.002, for CterFGF-23). In all subjects, Cter and intFGF-23 correlated inversely with sPi (r=−0.35, P<0.003; −0.35, P<0.003, respectively), and TmPi/GFR (r=−0.50, P<0.001; −0.54, P<0.001, respectively). In multivariate models, sPi and TmPi/GFR were independently associated with FGF-23, iPTH and eGFR. Pre-transplant iPTH levels were significantly higher in patients developing hypophosphatemia after renal transplantation. Pre-transplant levels of FGF-23 were not associated with sPi at the time of transplantation.ConclusionIn addition to PTH, elevated FGF-23 may contribute to hypophosphatemia during the early post-renal transplant period.

Renal tubular reabsorption of trace alkaline earths compared with calcium

1965 ◽  
Vol 208 (6) ◽  
pp. 1165-1170 ◽  
Author(s):  
W. Joseph Rahill ◽  
Mackenzie Walser
Keyword(s):  
Protein Binding ◽  
Transport Mechanism ◽  
Tubular Reabsorption ◽  
Constant Infusion ◽  
Constant Power ◽  
Calcium Clearance ◽  
Renal Tubular Reabsorption ◽  
Order Of Magnitude ◽  
Alkaline Earths ◽  
Renal Tubular

Simultaneous clearances of inulin, calcium, and either Be7, Ba140, or Ra226, given by constant infusion, were measured in salt-depleted dogs or dogs undergoing mild saline, mannitol, or sulfate diuresis. Urine-to-plasma ratios of all three cations less than 0.5 were noted, suggesting that all can be actively reabsorbed. Clearances of barium and radium were correlated with calcium clearance, but the clearance of beryllium was unpredictable. Protein binding of beryllium was shown to be of the same order of magnitude as other alkaline earths when errors due to adsorption of Be7 onto containers were minimized. Protein binding of barium averaged 54%. The excreted-to-filtered ratio for barium was a constant power (.54) of the ratio for calcium. The data do not exclude the possibility that these cations are reabsorbed by a common transport mechanism with calcium.

Renal Tubular Reabsorption of Glucose in Insulin-Treated Diabetics: Analysis of ‘Splay’

1978 ◽  
Vol 54 (2) ◽  
pp. 22P-23P
Author(s):  
R. J. Walton ◽  
B. E. Cluett ◽  
H. S. Platt
Keyword(s):  
Tubular Reabsorption ◽  
Renal Tubular Reabsorption ◽  
Renal Tubular
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