Lymphadenosis benigna cutis versus Primary Cutaneous B-Cell Lymphomas of Follicular Center Cell Origin

2015 ◽  
pp. 189-195 ◽  
Author(s):  
J. U. Rijlaarsdam ◽  
C. J. L. M. Meijer ◽  
R. Willemze
Keyword(s):  
B Cell ◽  
B Cell Lymphomas ◽  
Center Cell

scholarly journals Incidence and patterns of bone marrow and blood involvement by lymphoma in relationship to the Lukes-Collins classification

Blood ◽  
1979 ◽  
Vol 54 (6) ◽  
pp. 1417-1422
Author(s):  
K Foucar ◽  
RW McKenna ◽  
G Frizzera ◽  
RD Brunning
Keyword(s):  
Bone Marrow ◽  
T Cell ◽  
B Cell ◽  
Bone Marrow Involvement ◽  
Cell Types ◽  
B Cell Lymphomas ◽  
Morphological Classification ◽  
Bone Marrow Disease ◽  
T Cell Lymphomas ◽  
Center Cell

Pretreatment lymph nodes, bone marrow, and blood were examined in 176 cases of non-Hodgkin's lymphoma. By the criteria of the Lukes and Collins functional--morphological classification, 158 (90%) were B-cell lymphomas and 17 (10%) were T-cell lymphomas. Bone marrow involvement was present in 53% of cases: 51% of B-cell types and 65% of T-cell types. Marrow involvement was most frequent in small lymphocyte (B) (89%), convoluted lymphocyte (60%), and small cleaved follicular center cell (FCC) lymphomas (55%). The pattern of bone marrow involvement was most frequently focal paratrabecular in B-cell lymphomas and diffuse in T-cell lymphomas. Blood involvement was present in 50% of cases with bone marrow lymphoma and generally reflected extensive bone marrow disease. There was a higher incidence of both bone marrow and blood involvement in pediatric patients than in adults.

scholarly journals The bcl-2 gene is rearranged in many diffuse B-cell lymphomas

Blood ◽  
1988 ◽  
Vol 71 (4) ◽  
pp. 969-972 ◽  
Author(s):  
AC Aisenberg ◽  
BM Wilkes ◽  
JO Jacobson
Keyword(s):  
T Cell ◽  
B Cell ◽  
Cell Lineage ◽  
Large Cell ◽  
Chromosome Translocation ◽  
Lymphocytic Leukemia ◽  
Chain Gene ◽  
B Cell Lymphomas ◽  
Follicular Lymphomas ◽  
Center Cell

Abstract Southern blotting was used to detect rearrangement of the bcl-2 gene in 104 cases of non-Hodgkin's lymphoma subclassified by the Working Formulation, 24 cases of B cell chronic lymphocytic leukemia (B-CLL) and 14 cases of T cell malignancy. Earlier workers reported rearrangement of this gene (located on chromosome 18) in a major fraction of follicular lymphomas, lymphomas in which a 14;18 chromosome translocation is frequently observed. In the present study, bcl-2 was rearranged in 30% (11 of 37) of follicular lymphomas and 19% (11 of 58) of diffuse lymphomas of follicle center cell lineage. In 18 of 19 samples studied, the rearranged bcl-2 fragment also hybridized with a probe for the joining region of the immunoglobulin heavy chain gene located on chromosome 14, indicating a 14;18 translocation. In lymphomas not derived from follicle center cells, ie, diffuse lymphomas of small B lymphocytes, B-CLL and T cell neoplasms, the bcl-2 gene was always in germline configuration. The frequent rearrangement of bcl-2 in a variety of B cell lymphomas of diffuse morphology (small cleaved cell, large cell, small noncleaved cell and immunoblastic) is noteworthy.

VH Gene Analysis of Primary Cutaneous B-Cell Lymphomas: Evidence for Ongoing Somatic Hypermutation and Isotype Switching

Blood ◽  
1998 ◽  
Vol 92 (10) ◽  
pp. 3857-3864 ◽  
Author(s):  
W.M. Aarts ◽  
R. Willemze ◽  
R.J. Bende ◽  
C.J.L.M. Meijer ◽  
S.T. Pals ◽  
...  
Keyword(s):  
B Cell ◽  
Somatic Hypermutation ◽  
Large Cell ◽  
B Cell Lymphomas ◽  
Isotype Switching ◽  
Variable Heavy ◽  
Vh Gene ◽  
Vh Genes ◽  
Hodgkin's Lymphomas ◽  
Center Cell

Primary cutaneous B-cell lymphomas are B-cell non-Hodgkin’s lymphomas that arise in the skin. The major subtypes discerned are follicle center cell lymphomas, immunocytomas (marginal zone B-cell lymphomas), and large B-cell lymphomas of the leg. In this study, we analyzed the variable heavy chain (VH) genes of 7 of these lymphomas, ie, 4 follicle center cell lymphomas (diffuse large-cell lymphomas) and 3 immunocytomas. We show that all these lymphomas carry heavily mutated VH genes, with no obvious bias in VH gene usage. The low ratios of replacement versus silent mutations observed in the framework regions of 5 of the 7 lymphomas suggest that the structure of the B-cell antigen receptor was preserved, as in normal B cells that are selected for antibody expression. Moreover, evidence for ongoing mutation was obtained in 3 immunocytomas and in one lymphoma of large-cell type. In addition, in 1 immunocytoma, both IgG- and IgA-expressing clones were found, indicative of isotype switching. Our data provide insight into the biology of primary cutaneous B-cell lymphomas and may be of significance for their classification.

scholarly journals Immunophenotypic and Genotypic Markers of Follicular Center Cell Neoplasia in Diffuse Large B-Cell Lymphomas

2000 ◽  
Vol 13 (11) ◽  
pp. 1219-1231 ◽  
Author(s):  
Bruce E King ◽  
Carolyn Chen ◽  
Joseph Locker ◽  
Jeffrey Kant ◽  
Kazuhiko Okuyama ◽  
...  
Keyword(s):  
B Cell ◽  
B Cell Lymphomas ◽  
Center Cell ◽  
Large B Cell

scholarly journals Incidence and patterns of bone marrow and blood involvement by lymphoma in relationship to the Lukes-Collins classification

Blood ◽  
1979 ◽  
Vol 54 (6) ◽  
pp. 1417-1422 ◽  
Author(s):  
K Foucar ◽  
RW McKenna ◽  
G Frizzera ◽  
RD Brunning
Keyword(s):  
Bone Marrow ◽  
T Cell ◽  
B Cell ◽  
Bone Marrow Involvement ◽  
Cell Types ◽  
B Cell Lymphomas ◽  
Morphological Classification ◽  
Bone Marrow Disease ◽  
T Cell Lymphomas ◽  
Center Cell

Abstract Pretreatment lymph nodes, bone marrow, and blood were examined in 176 cases of non-Hodgkin's lymphoma. By the criteria of the Lukes and Collins functional--morphological classification, 158 (90%) were B-cell lymphomas and 17 (10%) were T-cell lymphomas. Bone marrow involvement was present in 53% of cases: 51% of B-cell types and 65% of T-cell types. Marrow involvement was most frequent in small lymphocyte (B) (89%), convoluted lymphocyte (60%), and small cleaved follicular center cell (FCC) lymphomas (55%). The pattern of bone marrow involvement was most frequently focal paratrabecular in B-cell lymphomas and diffuse in T-cell lymphomas. Blood involvement was present in 50% of cases with bone marrow lymphoma and generally reflected extensive bone marrow disease. There was a higher incidence of both bone marrow and blood involvement in pediatric patients than in adults.

VH Gene Analysis of Primary Cutaneous B-Cell Lymphomas: Evidence for Ongoing Somatic Hypermutation and Isotype Switching

Blood ◽  
1998 ◽  
Vol 92 (10) ◽  
pp. 3857-3864 ◽  
Author(s):  
W.M. Aarts ◽  
R. Willemze ◽  
R.J. Bende ◽  
C.J.L.M. Meijer ◽  
S.T. Pals ◽  
...  
Keyword(s):  
B Cell ◽  
Somatic Hypermutation ◽  
Large Cell ◽  
B Cell Lymphomas ◽  
Isotype Switching ◽  
Variable Heavy ◽  
Vh Gene ◽  
Vh Genes ◽  
Hodgkin's Lymphomas ◽  
Center Cell

Abstract Primary cutaneous B-cell lymphomas are B-cell non-Hodgkin’s lymphomas that arise in the skin. The major subtypes discerned are follicle center cell lymphomas, immunocytomas (marginal zone B-cell lymphomas), and large B-cell lymphomas of the leg. In this study, we analyzed the variable heavy chain (VH) genes of 7 of these lymphomas, ie, 4 follicle center cell lymphomas (diffuse large-cell lymphomas) and 3 immunocytomas. We show that all these lymphomas carry heavily mutated VH genes, with no obvious bias in VH gene usage. The low ratios of replacement versus silent mutations observed in the framework regions of 5 of the 7 lymphomas suggest that the structure of the B-cell antigen receptor was preserved, as in normal B cells that are selected for antibody expression. Moreover, evidence for ongoing mutation was obtained in 3 immunocytomas and in one lymphoma of large-cell type. In addition, in 1 immunocytoma, both IgG- and IgA-expressing clones were found, indicative of isotype switching. Our data provide insight into the biology of primary cutaneous B-cell lymphomas and may be of significance for their classification.

scholarly journals The bcl-2 gene is rearranged in many diffuse B-cell lymphomas

Blood ◽  
1988 ◽  
Vol 71 (4) ◽  
pp. 969-972 ◽  
Author(s):  
AC Aisenberg ◽  
BM Wilkes ◽  
JO Jacobson
Keyword(s):  
T Cell ◽  
B Cell ◽  
Cell Lineage ◽  
Large Cell ◽  
Chromosome Translocation ◽  
Lymphocytic Leukemia ◽  
Chain Gene ◽  
B Cell Lymphomas ◽  
Follicular Lymphomas ◽  
Center Cell

Southern blotting was used to detect rearrangement of the bcl-2 gene in 104 cases of non-Hodgkin's lymphoma subclassified by the Working Formulation, 24 cases of B cell chronic lymphocytic leukemia (B-CLL) and 14 cases of T cell malignancy. Earlier workers reported rearrangement of this gene (located on chromosome 18) in a major fraction of follicular lymphomas, lymphomas in which a 14;18 chromosome translocation is frequently observed. In the present study, bcl-2 was rearranged in 30% (11 of 37) of follicular lymphomas and 19% (11 of 58) of diffuse lymphomas of follicle center cell lineage. In 18 of 19 samples studied, the rearranged bcl-2 fragment also hybridized with a probe for the joining region of the immunoglobulin heavy chain gene located on chromosome 14, indicating a 14;18 translocation. In lymphomas not derived from follicle center cells, ie, diffuse lymphomas of small B lymphocytes, B-CLL and T cell neoplasms, the bcl-2 gene was always in germline configuration. The frequent rearrangement of bcl-2 in a variety of B cell lymphomas of diffuse morphology (small cleaved cell, large cell, small noncleaved cell and immunoblastic) is noteworthy.

Treatment of primary cutaneous B-cell lymphomas of follicle center cell origin: a clinical follow-up study of 55 patients treated with radiotherapy or polychemotherapy.

1996 ◽  
Vol 14 (2) ◽  
pp. 549-555 ◽  
Author(s):  
J U Rijlaarsdam ◽  
J Toonstra ◽  
O W Meijer ◽  
E M Noordijk ◽  
R Willemze
Keyword(s):  
Complete Remission ◽  
B Cell ◽  
Relapse Rate ◽  
Distinct Group ◽  
Skin Lesions ◽  
Treatment Modalities ◽  
B Cell Lymphomas ◽  
Favorable Prognosis ◽  
Center Cell

PURPOSE Primary cutaneous follicle center cell lymphomas (PCFCCL) are a distinct group of cutaneous B-cell lymphomas with a favorable prognosis after radiotherapy (RT) or polychemotherapy (PCT). In the literature, conflicting data exist regarding the efficacy and the relapse rate of both treatment modalities. In the present study, treatment results and follow-up data of a large group of PCFCCL are evaluated. PATIENTS AND METHODS Fifty-five patients with a PCFCCL who presented with skin lesions on either the head (n = 12), the trunk (n = 35), or lower legs (n = 8), and who were initially treated with RT (40 cases) or PCT (15 cases) were studied. RESULTS RT resulted in a complete remission in all 40 cases. Eight cases relapsed and three of these patients died as a result of their lymphoma. The estimated 5-year survival was 89%. Four of eight relapses and all three lymphoma-related deaths occurred in the group of patients presenting with tumor(s) on the lower legs. Treatment with cyclophosphamide, doxorubicin vincristine, and prednisone (CHOP) or cyclophosphomide, vincristine, and prednisone (COP) resulted in a complete remission in 14 of 15 cases. All four cases treated with COP relapsed, whereas only two of 11 patients treated with CHOP had a relapse. The estimated 5-year survival rate of the PCT group was 93%. CONCLUSION Both RT and CHOP PCT are highly effective modes of treatment for PCFCCL. In localized PCFCCL, RT is the treatment of choice. In patients with multiple tumors involving anatomic nonrelated parts of the skin, CHOP rather than COP PCT is the preferred mode of treatment. PCFCCL on the lower legs, a subgroup that characteristically occur in elderly patients, have a higher relapse rate and a less favorable prognosis than PCFCCL presenting on the head or trunk.

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